October 29, 2020 News by Marta Figueiredo, PhD MD1003 Fails to Prevent Disability Progression in Progressive MS Patients, Trial Shows MD1003, MedDay Pharmaceuticalsā high-dose biotin therapy, failed to significantly improve functional ability or walking speed in people with non-active progressiveĀ multiple sclerosis (MS), according to data from a Phase 3 clinical trial. Besides failing to meet the trialās goals, the therapy was associated with inaccurate results in…
March 13, 2020 News by Margarida Azevedo, MSc Second Phase 3 Trial of MedDay’s MD1003 for Progressive MS Fails to Meet Goals MedDay Pharmaceuticals‘Ā MD1003 did not ease functional disability or its progression in patients with non-active progressive multiple sclerosis, Phase 3 clinical trial data shows. The SPI2 Phase 3 study (NCT02936037) sought to confirm the positive results of a first Phase 3 trialĀ called MS-SPI…
January 2, 2019 News by Jose Marques Lopes, PhD Top 10 Multiple Sclerosis Stories of 2018 Multiple Sclerosis News Today brought you daily coverage of key findings, treatment developments, andĀ clinical trials related to multiple sclerosis (MS) throughout 2018. We look forward to reporting more news to patients, family members, and caregivers dealing with MS during 2019. Here are the top 10 most-read articles of…
November 14, 2018 News by Joana Carvalho, PhD Phase 3 Trial of MD1003 in Treating Progressive MS Fully Enrolled, MedDay Announces A Phase 3 clinical trial intending to confirm the potential ofĀ MD1003, a high-dose biotin, in treating progressive multiple sclerosisĀ (MS) patients is completely enrolled, MedDay Pharmaceuticals, the investigational therapy’s developer, announced. The randomized, double-blind, and placebo-controlled study (NCT02936037), called SPI2, follows the previous Phase 3 trial (NCT02220933),…
February 12, 2018 Columns by Ed Tobias MS News that Caught My Eye Last Week: 3rd Round of Lemtrada, Ampyra’s Possibilities, Long-term MD1003, Possible PML Treatment #ACTRIMS2018 ā Third Course of Lemtrada Improves Relapse, Disability in MS Patients, CARE-MS II Trial Shows The normal treatment regimen with Lemtrada is a series of two treatment courses, with the second infusion course given 12 months after the first. A “selling point” for this disease-modifying therapy (DMT) is…
February 8, 2018 News by Patricia Inacio, PhD #ACTRIMS2018 – MS Therapy MD1003’s Disability Improvements Hold Over Time, Study Shows MedDay Pharma’sĀ MD1003Ā leads to long-lasting improvements in progressive multiple sclerosis patients’ disability, a Phase 3 clinical trial follow-up study shows. Researchers presented the results at the thirdĀ Annual Americas Committee for Treatment and Research in Multiple Sclerosis ForumĀ in San Diego, Feb. 1-3. The poster presentation was titledĀ ā…
January 5, 2018 News by Patricia Silva, PhD Top 10 Multiple Sclerosis Articles of 2017 Multiple Sclerosis News Today brought you daily coverage of important discoveries, treatment developments, clinical trials, and other events dealing with multiple sclerosis throughout 2017. We look forward to providing more news to MS patients, family members, and caregivers during 2018. As a reminder of what mattered most to you in…
December 15, 2017 Columns by Ed Tobias Using Biotin? It Could Impact Your Lab Results Be careful if you’re using high-dose biotin (vitamin B7). The biotin in your blood could lead to some false readings when you have that blood tested. The level of concern about this is high enough to warrant aĀ warning from the U.S. Food and Drug Administration. High doses of biotin…
October 27, 2017 News by BioNews Staff #MSParis2017 ā Potential Progressive MS Treatment on Move in US and Europe, MedDay CEO Says This is a special edition of Multiple Sclerosis News Today's daily Alexa Flash Briefing, covering the latest news from the 7th Joint ECTRIMS-ACTRIMS Meeting currently underway in Paris, France. The MS News today team in on-site at the conference, providing exclusive coverage of the presentations and speakers.
October 26, 2017 News by Patricia Silva, PhD #MSParis2017 ā MedDayās High-Dose Biotin, MD1003, Improves Disability in Progressive MS Patients MD1003, a high-dose biotinĀ developed by MedDay, slowed or prevented further disease progression among progressive multiple sclerosis (MS) patients in a Phase 3 clinical trial, researchers announced at the Oct. 25ā28 7th Joint ECTRIMS-ACTRIMS Meeting in Paris, France. The effects of the treatment were seen to be upheld over…
August 15, 2017 Columns by Ed Tobias An MS Study You Might Want to Join I was surprised to see that a study of a potential MS drug labeled MD1003 is still accepting participants. It’s a study that I’d love to take part in, if only I was a few years younger. MD1003 is a high dose of biotin, a form of…
May 19, 2017 News by Joana Fernandes, PhD Phase 3 Study of High-Dose Biotin, MD1003, in Treating Primary and Secondary MS Patients Underway A Phase 3 clinical trial has been launched by MedDay Pharmaceuticals to investigate whether treatment with high-dose biotin (MD1003) may easeĀ disability and improve mobility in non-relapsing primary or secondary progressive MS patients. The study is recruiting participants across the U.S., Canada and Europe. Biotin is a form of…
May 9, 2017 News by Patricia Silva, PhD MedDay’s New Phase 3 Trial and Belief in Biotin’s Potential to Treat Progressive MS: An Interview with Dr. FrĆ©dĆ©ric Sedel A global Phase 3 clinical trial assessingĀ MD1003 ā also known as high-dose biotin ā for progressive multiple sclerosis (MS) might lead to the approval of one of the first treatmentsĀ helping selectĀ progressive patients to improve. The trial aims to prove that high-dose biotin can reverse disability in non-active progressive MS.
January 4, 2017 News by Joana Fernandes, PhD Top 10 Multiple Sclerosis Articles of 2016 A number ofĀ important discoveries, therapeutic developments, and events related to multiple sclerosis (MS) were reported dailyĀ by Multiple Sclerosis News Today throughout 2016. Now that the year is over, it is time to briefly review the articles that appealed most toĀ ourĀ readers. Here are the top 10 most-read articles of 2016, with…
May 31, 2016 News by Patricia Silva, PhD MedDay Presents Phase 3 Extension Data on Potential Drug to Treat Progressive MS Data from an extension phase of aĀ Phase 3 clinical trial, given in an oral presentation by MedDay, reportedĀ that the biotinĀ Ā MD1003 showedĀ effectiveness over time as a possibleĀ treatment of non-active, progressive multiple sclerosis (MS). The dataĀ were presented atĀ the recentĀ 2nd Congress of the European Academy of Neurology (EAN) in DenmarkĀ byĀ ProfessorĀ Ayman Tourbah,…
April 27, 2016 News by Patricia Silva, PhD MedDayās MD1003, a Biotin, Shows ‘Remarkable’ Efficacy in Treating Inactive but Progressive MS in Clinical Trials MedDayĀ recently disclosed full study results from the MS-SPI and MS-ON Phase 2b/3 trials ofĀ its therapeutic candidate MD1003 in patients with multiple sclerosis (MS). Specifically, the trials included people with “not active”Ā progressive MS and those with either relapsing or progressive MS andĀ visual loss, respectively. Data, presented at the recentĀ American…
April 12, 2016 News by Patricia Silva, PhD MedDay Raises $38.5M to Finance Phase 3 Trial Targeting Progressive MS MedDay SASĀ recently announced that it has raised ā¬34 million, about $38.5 million, in a Series B financing round. The moneyĀ will enable the company to lead a confirmatory Phase 3 clinical trial, called SPI2, in the United StatesĀ toĀ assess itsĀ lead candidate, MD1003, as a treatment for progressive multiple sclerosis (MS). MedDayĀ concluded…
October 13, 2015 News by Patricia Silva, PhD Insights into Promising MS Therapies at Late Breaking News Session, ECTRIMS 2015 A session titled āLate Breaking Newsā was featured at the 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Oct. 7-10, 2015, in Barcelona, Spain. At this session, Prof. Xavier Montalban from the Hospital Vall d’Hebron University in Barcelona presented data on the promising Genentech/Roche…
September 25, 2015 News by Charles Moore New MS Drug To Be Distributed By Global Supply Chain Distributor Durbin Medical Need Europe, a privately held pharmaceutical company headquartered in Sweden and focused on registration, distribution, marketing and sale of orphan drugs and niche speciality pharmaceuticals for treatment of rare diseases, has appointed London, U.K. based Durbin PLC, a leading global supplier and distributor of pharmaceuticals, to manage…
June 23, 2015 News by Patricia Silva, PhD MedDay Reveals Promising Data on Progressive Multiple Sclerosis Therapy MedDay, a biotechnology company dedicated to developing therapies for nervous system disorders, recently announced encouraging data on its pivotal Phase III clinical trial (MS-SPI) assessing the safety and efficacy of the company’s investigationalĀ therapy MD1003 for the treatment of progressive multiple sclerosis (MS). The data was presented at The…
April 23, 2015 News by admin Phase III Study of Experimental MS Therapy Meets Primary Endpoint, Results to be Presented at ANN Meeting MedDay, a French biotechnology company that studies treatments for nervous system disorders, including multiple sclerosis, announced that MD1003, a highly-concentrated biotin, is effective forĀ treatment of progressive multiple sclerosis, according to results from a recent Phase III trial. MD1003 may have two beneficial effects: 1) increasing myelin, the fatty nerve-insulating…
April 10, 2015 News by Patricia Silva, PhD MedDay To Release Phase III Clinical Trial Results for Experimental Progressive Multiple Sclerosis Therapy MedDayĀ recently announced in a news releaseĀ that it is preparing to release the design and results of its clinical trial to assess the safety and efficacy of MD1003 in primary and secondary progressive multiple sclerosis (MS) treatment. Data on the Phase III clinical trial (MS-SPI) will be presented…
April 8, 2015 News by Charles Moore MedDay Updates Status Of Pioneering Pivotal Phase III Study Design In Progressive Multiple Sclerosis MedDay, a Paris, France based biotechnology company specializing in treatment of neurological disorders, has released more information regarding the design of its (MS-SPI) clinical trial that is investigating the efficacy and safety of the investigational medicine MD1003 in treatment of primary and secondary progressive multiple sclerosis (MS). Progressive…
March 13, 2015 News by admin Two Progressive MS Phase III Trials to be Presented at AAN Annual Meeting Myelin — the fatty substance that wraps around nerve cells — is lost in multiple sclerosis (MS). Is there any way to get it back or to stop the deterioration of myelin? Researchers at MedDay Pharmaceuticals think that their drug may provide the solution. Known asĀ MD1003, the…
January 19, 2015 News by Patricia Silva, PhD MedDay Provides Update on Pipeline Progress for Primary & Secondary Progressive Multiple Sclerosis Drug MedDay, a biotechnology company that develops new drugs for nervous system disorders, announced an update on the progress of its development pipeline with its leadĀ product MD1003 for the treatment of primary and secondary progressive multiple sclerosis (MS). The first study is expected to be complete in early 2015, while…