EMD Serono Announces Publication of PRISMS-15 Years Follow-up Study Results on Rebif for Relapsing–Remitting Multiple Sclerosis

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EMD Serono, the U.S. biopharmaceutical division of Merck KGaA, Darmstadt, Germany, recently announced that the results of the 15 year follow-up trial PRISMS-15 (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) evaluating Rebif® (interferon beta-1a), a high-dose, high-frequency interferon beta for the treatment of patients with relapsing forms of multiple sclerosis (MS), were published in the Journal of Neurology, Neurosurgery and Psychiatry (JNNP). The study is entitled “Factors influencing long-term outcomes in relapsing–remitting multiple sclerosis: PRISMS-15“.

The study reveals clinical data from a pivotal trial examining the association between cumulative exposure to treatment with subcutaneous (sc) interferon (IFN) beta-1a and other potential predictive factors in patients with a diagnosis of relapsing–remitting multiple sclerosis (RRMS).

“The publication of the PRISMS-15 study in JNNP offers the MS medical community a retrospective single visit assessment in a subset of RRMS patients from the PRISMS trial with varying exposure to Rebif,” said Dr. Rick Munschauer, Vice President, Medical Affairs, Neurology and Immunology, EMD Serono in a press release.

Rebif is used to decrease or delay the manifestation of some of the physical disability and frequency of relapses  in MS patients. The study revealed that the cumulative exposure and long-term treatment with IFN beta-1a (sc) seemed to be linked to better clinical outcomes in terms of number of relapses, annualized relapse rate, time to Expanded Disability Status Scale (EDSS) progression, change in EDSS, and conversion to secondary-progressive MS (SPMS).

In addition to Rebif, the company is involved in strategic research partnerships with leading healthcare and academic institutions for the funding and encouragement of research in the field of neurology.

EMD Serono also has ongoing MS research programs with a Phase I clinical trial on ATX-MS-1467, an investigational drug for the treatment of patients with RRMS, and a Phase IIb clinical trial on imilecleucel-T, a drug candidate for the treatment of patients with a diagnosis of secondary progressive MS (SPMS), a condition with a high unmet medical need. The company has an option arrangement with Opexa Therapeutics, Inc. for the development and commercialization of imilecleucel-T.

RRMS is characterized by clearly defined attacks of worsening neurologic function. These attacks — often called relapses, flare-ups or exacerbations — are followed by partial or complete recovery periods (remissions), during which symptoms improve partially or completely, and there is no apparent progression of disease. RRMS is the most common disease course at the time of diagnosis, with around 85 percent of people being initially diagnosed with RRMS, compared to 10-15 percent with progressive forms of the disease.

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Daniela holds a PhD in Clinical Psychology from The University of Edinburgh, United Kingdom, a MSc in Health Psychology and a BSc in Clinical Psychology. Her work has been focused on vulnerability to psychopathology and early identification and intervention in psychosis.
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  1. LYNNE HEAL says:

    All these MS drugs are all bad everyone of them all being promoted for profits, shares and commissions alongside very high salaries its so full of corruptions and greed to the core many making billions upon billions . Its an utter disgrace to mankind

    • Spoken Axle says:

      Lynne, then don’t take them. Nobody’s forcing you. Just be sure to come back in 15 years and let us all know how your MS is doing.

      • LYNNE HEAL says:

        In reply to Spoken Axle had MS for 43 years NO MS drugs ever taken thankfully . I even worked 7 days a week with secondary progressive MS . I am 100% proof of whats really going on in MS

  2. Jana says:

    I take these drugs too but I feel the exact same way Lynne Heal does. There is no more money if there is a cure. That’s the reason why all these drug companies have patents on the compounds they find. Hey, if they come up with something that is truly worthwhile, I’ll be the first to admit it I was wrong and sign me up for it ASAP.

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