5 Things to Know About the New MS Drug Ocrevus

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by Wendy Henderson |

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BREAKING NEWS: FDA Approves Ocrevus as 1st MS Treatment for Both Relapsing and Primary Progressive Forms

The multiple sclerosis community has been waiting with bated breath for the approval of the drug Ocrevus (ocrelizumab), which will be used to treat patients who have relapsing MS and primary progressive MS. The FDA’s decision of final approval is expected on March 28, which coincides with Multiple Sclerosis Awareness Week. In preparation for the announcement, we’ve put together a list of must-know facts about the drug.

Ocrevus will be used for treating primary progressive MS. 

In clinical trials, Ocrevus was found to slow the progress of disability in primary progressive multiple sclerosis (PPMS), which accounts for approximately 10 percent of MS patients.

Ocrevus will also be used for treating relapsing MS patients. 

Ocrevus was found to slow disease activity in more patients taking the drug compared to those who were taking Rebif.

Ocrevus targets myelin-attacking B-cells. 

Ocrevus is an anti-CD20 monoclonal antibody which works by targeting the mature B-cells which contribute to demyelination and damage to nerve cells. Most MS medications currently available work by targeting T-cells. This is one of the only medications that attacks these specific B-cells.

RELATED: Our columnist Ian Franks gives his views on the impending approval of Ocrevus.

The outcome of the clinical trials. 

More than 1,600 MS patients participated in clinical trials for Ocrevus and 94 percent of participants had fewer brain lesions during the 96 weeks of treatment.

There was little increased risk of infection. 

The clinical trials for Ocrevus also found that while patients taking the drug did have a slightly increased risk of common colds and flu, they had no significant increased risk of other infections when compared to patients taking the alternative medication, Rebif.

RELATED: Read more from Genentech’s medical director, Peter Chin, about Ocrevus and what it means for the MS community.

Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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