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Ocrevus Treatment and Side Effects: What’s Important to Know


There are other long-term risks associated with Ocrevus and patients with active hepatitis B or are allergic to Ocrevus are not advised to begin the therapy. Other side effects include:

Infections: Ocrevus increases the risk of infections such as respiratory infections, herpes, and skin infections.

Reactivating hepatitis B virus: You should speak to your healthcare team if you’ve had hepatitis B.

Progressive multifocal leukoencephalopathy (PML): Although no patient on the clinical trials for Ocrevus developed this rare brain infection, there is a risk that this could occur.

A weakened immune system: If Ocrevus is taken with other multiple sclerosis medications it may lead to a weakened immune system and leave patients more susceptible to infections.

Cancer: Ocrevus may increase your risk of developing certain types of cancer, including breast cancer. You will need to ensure you have regular cancer screenings.

MORE: Ocrevus seen in Phase 3 clinical trials to benefit RRMS and PPMS

Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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      • Kym says:

        Hi. I am Secondary Progressive, and yesterday I had my first full infusion of Ocrevus. My Dr. said, if it’s good for Primary Progressive, and Remitting Relapsing, why wouldn’t it work for Secondary Progressive? So I signed up. But, I also know other people who have SPMS that cannot get it. I guess it up the Dr. I’ve had no side effects. I just want it to slow the progression! Good luck to you!!

  1. Laura says:

    How is this different from Ampyra which from reading patient reviews has less severe sides effects, taken in pill form, and results seem to be in many cases immediate,and far less costly? Additionally I noticed you have to be productive in your own healthcare.

    • Dennis R. says:

      Ampyra does not do anything to modify the disease and improves walking ability in most patients (treats one of the symptoms and not the disease). Ocrevus modifies your immune system (by eradicating certain immune cells that damages your nervous system, specifically the myelin sheath that protects your nerve cells.

      I am currently taking Ampyra and Rituxan (Ocrevus is very similar to Rituxan).

  2. Dennis R. says:

    Ampyra is used to improve walking for most patients and does not do anything to modify disease progression. Ocrevus eliminates specific immune cells to reduce damage to your nervous system. Neither drug cures MS.

  3. Regina Alfonso says:

    Is there any research on the incidence of MS in children who are the offspring of parents when BOTH parents have MS? My daughter and her husband were diagnosed some years after they got married. They have 2 children ages 4 and 6.

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