Results from a small pilot study indicated that high-dose vitamin D supplementation is safe and tolerable in patients with multiple sclerosis (MS), and that it can reduce the presence of autoimmunity-causing immune T cells. Patients are now being recruited for a larger clinical trial. The study, entitled “Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis” and was published in the journal Neurology.
Growing scientific evidence indicates that vitamin D plays an important role in MS. Reduced levels of vitamin D, possibly due to low sun exposure, are being investigated as a risk factor for the disease. And the vitamin’s beneficial effect has been observed in mice with experimental autoimmune encephalomyelitis (EAE), an MS-like disease, leading researchers to believe that vitamin D may have a protective effect against autoimmune diseases such as MS.
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