Raltegravir (isentress) is an antiretroviral medicine currently used to treat HIV. It works by stopping the virus from replicating.
Research found that Human Endogenous Retrovirus (HERV), a family of viruses in the human genome similar to retrovirus, can be a cause or trigger for multiple sclerosis (MS). Because HERV are involved in certain cancers and autoimmune diseases including multiple sclerosis (MS), Raltegravir was tested as a potential RRMS treatment.
The study INSPIRE (NCT01767701) aimed to determine if isentress is effective in preventing the progression of RRMS. The participants took raltegravir for three months and underwent monthly MRI scans. By the end of the study, raltegravir failed to prove any benefit — it not reduce MS inflammation.
There is no information currently available concerning raltegravir’s future role in MS treatment.
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