Raxone (idebenone) is a man-made drug similar to the naturally occurring antioxidant coenzyme Q10. It is currently under development by Santhera Pharmaceuticals. Because coenzyme Q10 is an antioxidant dietary supplement thought to play a major role in cell survival, researchers are investigating whether idebenone can protect against the brain and spinal cord damage that leads to worsening disability in primary progressive multiple sclerosis (PPMS) patients.
Idebenone was initially developed to treat Alzheimer’s disease and other cognitive defects.
There are two ongoing Phase 2 studies (NCT01854359 and NCT00950248) currently evaluating idebenone’s safety, effectiveness, and mechanism of action as a primary progressive multiple sclerosis treatment. The studies will likely be completed by August 2018.
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