June 21, 2022 News by Marisa Wexler, MS T-cells in Bone Marrow Work to Drive Inflammatory MS Attacks Unusual growth in anĀ immune cell classĀ called myeloid cells is evident in the bone marrow of people with multiple sclerosis (MS), and these cells likely contribute to the inflammation that drives the disease, according to a new study. Experiments in mice suggest that myelin-reactive T-cells can migrate to the bone…
April 18, 2022 News by Marisa Wexler, MS Progressive MS Trial Finds Repeat Bone Marrow Infusion Safe, Feasible Repeat harvesting of bone marrow cells and infusing them back into the bloodstream is safe and feasible in people with active progressive multiple sclerosis (MS), according to data from a small, proof-of-concept clinical trial. Results were detailed in the study, “Repeat infusion of autologous bone marrow…
February 11, 2022 News by Margarida Maia, PhD Blood Stem Cell Transplant May Help Immune System Longer Treatment with an autologous hematopoietic stem cell transplant (aHSCT) seems to reboot the immune system in multiple sclerosis (MS) patients for at least three years, a small study found. The study, āSustained immunotolerance in multiple sclerosis after stem cell transplant,ā was published in Annals of Clinical and…
June 10, 2021 News by Aisha I Abdullah PhD Inflammatory Immune Cells Found in Active, But Not Chronic, Brain Lesions A class of immune cells called myeloid cells that express the inflammatory protein SIGLEC1 may be able to distinguish between active and chronic multiple sclerosis (MS) brain lesions, a study found. The study, āSIGLEC1 (CD169): a marker of active neuroinflammation in the brain but not in the blood…
January 25, 2021 News by Joana Carvalho, PhD Stem Cell Transplant Can Produce Long-term Benefits in Relapsing MS Patients A stem cell transplant can prevent disability progression and maintain disease remission over long periods of time in most patients with relapsing forms of multiple sclerosis (MS) who failed to respond adequately to disease-modifying therapies (DMTs), a study reports. The study, āLong-Term Clinical Outcomes of Hematopoietic…
December 9, 2020 News by Marta Figueiredo, PhD Mesenchymal Stem Cell Transplant With NG-01 Treatment Shows Promise in Progressive MS Treatment with NG-01 ā an approach that uses patientsā own mesenchymal stem cells (MSCs) ā safely and effectively delayed disease progression in people with active, progressive multiple sclerosisĀ (MS), according to final data from a Phase 2 clinical trial. Delivering these cells directly into the cerebrospinal fluid (CSF)…