October 18, 2022 News by Marisa Wexler, MS MS Therapy EHP-101 Boosts Blood Vessel Growth, Targets Inflammation EHP-101, an experimental treatment being clinically tested for multiple sclerosis (MS), activates a cellular signaling pathway that promotes blood vessel development and reduces inflammation following brain injury, a new study shows. The findings continue to support the use of EHP-101 in MS, a condition marked by excess inflammation and…
March 23, 2022 News by Marisa Wexler, MS Scientists Review State of Cannabis Research in MS Treatment with cannabis-based medications may ease muscle spasms, decrease pain, and aid in sleep for people with multiple sclerosis (MS), but more research is needed to evaluate the potential benefits of cannabis use. That is the finding of a team of U.S. researchers who published a review paper,Ā “…
January 17, 2022 Columns by Ed Tobias MS News That Caught My Eye Last Week: Epstein-Barr Virus, EHP-101, Anti-CD20 Therapies, Gut Bacteria Epstein-Barr Virus May be Leading Cause of MS, Raising Risk by 32 Times Several studies over the past few years have suggested a link between the Epstein-Barr virus (EBV) and multiple sclerosis (MS), but this one is huge, both in the number of participants and in the length…
July 8, 2021 News by Patricia Inacio, PhD Sativex Eased MS Spasticity as an Add-on Therapy Sativex (nabiximols), an oral spray that contains cannabis extracts, was found effective as an add-on therapy for easing spasticityĀ in adultĀ multiple sclerosisĀ (MS) patients who failed to respond to other anti-spastic treatments,Ā a real-world study from Belgium reports. Overall, about 74% patients reported easing of spasticity ā muscle stiffness or…
January 14, 2021 News by Forest Ray PhD Public-private Partnership Will Assess Therapy Potential, Effects of CBD Open Book Extracts (OBX) and Case Western Reserve University School of Medicine have partnered to investigate how cannabinoids like CBD affect brain cells, particularly in regard to neuroinflammation, according to an OBX press release. CBD (cannabidiol) and other cannabinoids, such as THC (tetrahydrocannabinol), have attracted interest for…
September 23, 2020 News by Marisa Wexler, MS Medical Cannabis Lozenges Now Available for MS Patients in Texas People in Texas with multiple sclerosisĀ (MS) and other medical conditions now have access to cannabis-infused lozenges, Surterra TexasĀ announced. Under a Texas Compassionate Use Program, cannabis-containing therapies may be prescribed to help treat various neurological and other disorders, includingĀ terminal cancer, spasticity,…
July 10, 2020 News by Joana Carvalho, PhD Trial of Cannabis Derivatives in Treating MS Spasticity to Open in Canada The Multiple Sclerosis Society of Canada and its partner, the Canadian Institutes of Health Research (CIHR), have invested CA$1.5 million to open a clinical trialĀ that will investigate the potential of two cannabis derivatives ā cannabidiol (CBD) and tetrahydrocannabinol (THC) ā in treatingĀ spasticity (muscle stiffness) and other…
March 31, 2020 News by Marisa Wexler, MS Canada Rules EHP-101, Potential Cannabidiol Treatment, Not Controlled Substance EHP-101, a cannabidiol-derived investigational therapy being developed by Emerald Health PharmaceuticalsĀ (EHP)Ā to treat multiple sclerosis (MS), is not a controlled substance in Canada, the company announced. The active ingredient in EHP-101 is a derivative of cannabidiol, abbreviated CBD. This is one of the most well-known active compounds in…
October 31, 2019 News by Ana Pena PhD Medicinal Cannabinoids Not Effective for Mental Disorders, Small Relief on MS Anxiety, Analysis Suggests A joint analysis of 83 studies, involving 3,000 people, concluded that there is “scarce evidence” to say that the use of medicinal cannabinoids ā chemical compounds in the cannabis plant ā is able to improve mental health conditions. However, the use of pharmaceutical tetrahydrocannabinol (THC) may lead to…
September 18, 2019 News by Marisa Wexler, MS FTC Warns Companies Against Unsubstantiated Advertising of CBD Products for MS The U.S. Federal Trade Commission (FTC) sent warning letters to three companies that sell cannabis-based products containing cannabidiol (CBD), cautioning them that making unsubstantiated claims about the health benefits of CBD could lead to legal action. The agency “urges the companies to review all claims made for their…
August 27, 2019 News by Marisa Wexler, MS Phase 1 Clinical Trial of EHP-101 Concludes with Positive Safety Results The first in-human clinical trial of EHP-101, an investigational treatment for multiple sclerosis (MS) and systemic scleroderma (SSc), has been successfully completed,Ā Emerald Health PharmaceuticalsĀ (EHP) announced. EHP-101 demonstrated it was safe and well-tolerated in healthy volunteers, supporting further clinical development ofĀ EHP-101 in future Phase 2 clinical trials. The…
August 16, 2019 News by Alana Kessler MS RD Wahls Seminar Provides Different Perspectives on Managing MS: A Nutritionist’s View āDiet is profound. Lifestyle is profound. All patients should be taught how profound these things are.āĀ ā Terry Wahls, MS thriver and founder of the Wahls ProtocolĀ Western medicine has long approached multiple sclerosis (MS) and autoimmune disorders through traditional methods. While there have been…
August 5, 2019 News by Joana Carvalho, PhD Under-the-skin CBD Infusion With Valeritas’ h-Patch Device Prolongs Therapy Effects, Study Finds Valeritas Holdings‘ proprietary h-Patch device can be used to administer cannabidiol by an under-the-skin (subcutaneous) infusion, prolonging the time the medication remains in circulation in the body and maximizing its therapeutic effects, a preclinical study has found. Cannabidiol (CBD) is a cannabis-derived, purified liquid formulation that has…
July 9, 2019 News by Ana Pena PhD Cannabidiol-based Oral Treatment Seen to Promote Remyelination in Mice, Trial Planned in MS Patients EHP-101, a cannabidiol-based experimental therapy for multiple sclerosis, was able to recover myelin in damaged nerve fibers and lessen neuroinflammation in a mouse model of MS, data show. Emerald Health Therapeutics, the manufacturer of EHP-101, also announced plans to open Phase 2 clinical trials in patients by…
April 23, 2019 News by Ana Pena PhD Main Ingredient in Potential MS Therapy EHP-101 Not a Controlled Substance, DEA Rules The U.S. Drug Enforcement Administration (DEA)Ā has determined that theĀ cannabidiol-based active ingredient of EHP-101, an investigational oral treatment for multiple sclerosis (MS)Ā under development by Emerald Health Pharmaceuticals (EHP), should not be classified…
October 1, 2018 News by Diogo Pinto Cannabidiol-derived Treatment for MS, EHP-101, Enters Phase 1 Safety Study, Emerald Health Says Emerald Health PharmaceuticalsĀ announced that it has begun enrolling healthy volunteers for a Phase 1 clinical trial evaluating the safety and tolerability ofĀ EHP-101,Ā a potential cannabidiol treatment for multiple sclerosis (MS) and scleroderma. The randomized, double-blind, and placebo-controlled study (ACTRN12618001390279p) will Ā investigate the safety and pharmacokinetics (how…
August 27, 2018 Columns by Ed Tobias MS News that Caught My Eye Last Week: Cannabis and Inflammation, Exercise and MS, a New MS Subtype Cannabidiol Increases Inflammatory Suppressor Cells, New MS Mouse Study Shows There’s quite a bit of anecdotal evidence that the use of marijuana can help reduce the symptoms ofĀ multiple sclerosis (MS). Here’s a report about a study that suggests a reason that could be happening. Non-psychoactiveĀ cannabidiol (CBD),…
August 24, 2018 News by Patricia Inacio, PhD Cannabidiol Increases Inflammatory Suppressor Cells, New MS Mouse Study Shows Non-psychoactiveĀ cannabidiol (CBD), one of the active compounds in medicalĀ cannabis, significantly reduced clinical signs of multiple sclerosis (MS)-like disease in an experimental autoimmune encephalomyelitis mouse model. Researchers found that CBD promoted the increase of inflammatory-suppressor cells calledĀ myeloid-derived suppressor cells. The findings were reported in the study āCannabidiol Attenuates Experimental Autoimmune…
August 24, 2018 News by Jose Marques Lopes, PhD Work Showing Potential of EHP-101 in MS Earns Research Award Carmen Navarrete, PhD, has been granted a Scientific Innovation Award for her post-doctoral presentation suggesting that theĀ multiple sclerosisĀ (MS) treatment candidateĀ EHP-101Ā is anti-inflammatory and may boost remyelination,Ā Emerald Health PharmaceuticalsĀ announced. Navarrete, a senior scientist at Vivacell Biotechnology Espana, a company owned by Emerald Health Research, received the award at the…
June 29, 2018 News by Vijaya Iyer, PhD Sativex Relieves Pain in MS Patients, Italian Study Confirms Researchers confirmed that Sativex spray is beneficial in alleviating pain in patients with multiple sclerosis (MS), and also improved their pain sensitivity to cold temperatures. The study reporting the findings, āPain Modulation after Oromucosal Cannabinoid Spray (SATIVEX) in Patients with Multiple Sclerosis: A Study with Quantitative…
June 7, 2018 News by Alice MelĆ£o, MSc #CMSC2018 ā Pharmacist Discusses Advances, Challenges in Cannabinoids Research to Treat MS Several studies have demonstrated the therapeutic potential of cannabis and its derivate products to manage the symptoms of multiple sclerosis (MS) and other neurodegenerative diseases. But there is still much to be done to enhance their use and accessibility to patients who may benefit from these therapies, according to…
March 23, 2018 News by Patricia Inacio, PhD Emerald’s Cannabinoid-derived EHP-101 Enhances Remyelination in 2 MS Mouse Models Emerald Health‘sĀ investigational cannabidiol-derived EHP-101 reduces neuroinflammation, the risk of loss of myelin, and nerve cell damage in two mouse models of multiple sclerosis (MS), a new study shows. These results support the potential therapeutic benefits of EHP-101 for MS, and Emerald Health Pharmaceuticals expects to launch a human…