June 1, 2022 News by Marisa Wexler, MS New Scale May Better Assess MS Changes, Therapy Response in Mice A new scoring system might more precisely evaluate disease development, severity, and treatment response in a commonly used mouse model of multiple sclerosis (MS) known as the experimental autoimmune encephalomyelitis or EAE model, scientists report. This scoring system, called “I AM D EAE,”Ā was described in the study, “…
October 27, 2021 News by Marisa Wexler, MS Cold Eases Inflammation, Disease Severity in MS Mouse Model Colder ambient temperatures may ease the inflammation that drives multiple sclerosis (MS), early research in a mouse model suggests. Animals whose environment for two weeks was set at 10 C (about 50 F) had a “pronounced attenuation” of disease severity and other benefits compared with those kept at a…
March 11, 2021 News by Margarida Maia, PhD Vitamin D Supplements at Preclinical Stage Prevented MS in Mice Vitamin D, but not paricalcitol (a vitamin D analog), can be used as a preventive measure to control the severity of multiple sclerosis (MS), according to a new study of mice. The study, āPreclinical therapy with vitamin D3 in experimental encephalomyelitis: Efficacy and comparison with paricalcitol,ā was…
December 3, 2020 News by Steve Bryson, PhD Nasal Delivery of Interferon-beta at Lower Doses Shows MS Treatment Potential in Mice Nasal delivery of Rebifās active ingredient interferon-beta, loaded in carbohydrate-based nanoparticles, reduced disease progression and nerve cell inflammation in a preclinical mouse model of multiple sclerosis (MS), a study demonstrated. This alternate, non-invasive, low-cost treatment strategy…
May 8, 2020 News by Patricia Inacio, PhD ZyVersaās IC 100 Reduced Inflammation in MS Mouse Model, Study Finds IC 100, a monoclonal antibody by ZyVersa Therapeutics that prevents the assembly ofĀ inflammasomesĀ ā a pro-inflammatory cellular complex ā lessened inflammation and halted disease progression inĀ multiple sclerosis (MS), a study of mice shows.xa The study, āIC100: a novel anti-ASC monoclonal antibody improves functional outcomes…
April 28, 2020 News by InĆŖs Martins, PhD Rituximab May Prevent MS if Given at Earliest Disease Signs, Mouse Study Suggests Using rituximab to preventĀ multiple sclerosis (MS) in people at risk or in patients still without motor symptoms, and continuing treatment as the disease develops, may be a promising way to avoid inflammation andĀ myelinĀ loss in the brain, a study in mice suggests. In an animal model of MS,…
November 19, 2019 News by Steve Bryson, PhD Blocking Molecule Prevents B-cells from Entering Brain and Promoting MS Progression, Study Reports Stopping the migration of immune B-cells through the blood-brain barrier by blocking ALCAM, a molecule linked to the progression of multiple sclerosis (MS), lessened disease severity in an MS mouse model, a new study shows. Details of the discovery were reported…
November 13, 2019 News by Joana Carvalho, PhD Single Dose of CD45-ADC Resets the Immune System, Delays the Onset of MS in Mice A single dose of CD45-ADC, an investigational targeted therapy being developed to treat different types of autoimmune diseases, is enough to reset the normal function of the bodyās immune system in a mouse model of multiple sclerosis (MS), and to delay onset of the disease. Those findings…
October 29, 2019 News by Steve Bryson, PhD UV-B Light Prevents MS Symptoms in Mice Independently of Vitamin D, Study Finds Exposure to UV-B light prevented multiple sclerosis (MS)-like symptoms in a mouse model regardless of the presence of vitamin D or the vitamin D receptor, a new study discovered.Ā The study, āUV light suppression of EAE (a mouse…
October 10, 2019 News by Marta Figueiredo, PhD Blocking LRP1 May Halt Inflammation, Promote Remyelination, Mouse Study Suggests Blocking production of the low-density lipoprotein receptor-related protein 1 (LRP1) ā involved in inflammatory and immune responses ā specifically in myelinĀ repair cells halts neuroinflammation and promotes myelin repair, a preclinical study shows. These results, fromĀ two mouse models of multiple sclerosis (MS), shed light on the underlying mechanisms…
September 13, 2019 News by Joana Carvalho, PhD #ECTRIMS2019 ā Eliminating SARM1 Protects Neurons in Mouse Model of MS Eliminating SARM1, an enzyme that plays a key role in nerve cell degeneration, protects neurons in mice with experimental autoimmune encephalomyelitis (EAE), a condition that mimics the key pathological features of multiple sclerosis (MS) in humans. The preclinical findings were presented by researchers atĀ Disarm Therapeutics in a…
August 9, 2019 News by Jose Marques Lopes, PhD Harnessing T-cell Subtype May Suppress Immune Responses in MS, Study Suggests Though known mainly for killing tumor and virally infected cells, a T-cell subtype may restrain immune responses and be protective in autoimmune diseases such as multiple sclerosis (MS), according to new research. The study, āOpposing T cell responses in experimental autoimmune encephalomyelitis,ā was published recently in…
May 2, 2019 News by Patricia Inacio, PhD Estrogen Promotes Remyelination in Adult Brains of MS Mice, Study Shows Giving estrogen to two different adult mouse models of multiple sclerosis (MS), including the experimental autoimmuneĀ encephalomyelitis (EAE) model, promoted remyelination, a new study shows. Exposure to the hormone affected gene activity in oligodendrocytes, tricking them into producing myelin (the fatty substance that protects nerve cells, and that is destroyed…
March 14, 2019 News by Jose Marques Lopes, PhD Fatty Acid Pentanoate May Be Effective Treatment for MS, Other Autoimmune Diseases, Mouse Study Suggests Increased production of an anti-inflammatory molecule called interleukin (IL)-10, and suppression of a subtype of immune T-cells, may mean that a fatty acid called pentanoate is effective against inflammatory and autoimmune diseases such as multiple sclerosis (MS), according to new research in mice. The study, āThe…
February 13, 2019 News by Jonathan Grinstein Early-life Antibiotic Use Disrupts Gut Microbiota and Immune System, MS Rat Study Finds Early-life use of antibiotics disrupts gut microbiota in a rat model of multiple sclerosisĀ (MS) and provokes nervous system autoimmunity, ultimately aggravating disease severity, new research shows. Results also indicate early-life antibiotic use may have unfavorable consequences on regulation of the immune system. The research article, ā…
January 25, 2019 News by Jose Marques Lopes, PhD Chi3l3 Protein Favors Production of Myelin Repair Cells, Mouse Study Determines A protein marker for activated immune cells called Chi3I3 is key for the production of myelin-forming cells, and may become a target to boost myelin repair in multiple sclerosis (MS), according to a new study. The research, āChi3l3 induces oligodendrogenesis in an experimental model of autoimmune…
December 5, 2018 News by Patricia Inacio, PhD Aspirin Suppresses MS Symptoms by Preventing Loss of Regulatory T-cells, Mouse Study Shows Aspirin, administered orally at low doses, was sufficient to suppress multiple sclerosis (MS) symptoms in a mouse model of relapsing-remitting MS (RRMS) and chronic MS, a study reports. The clinical benefits of aspirin were linked to an increase in the number of regulatory T-cells, those responsible for shutting…
November 27, 2018 News by Ana Pena PhD Homotaurine Compound May Be New Class of Treatment for MS, Mouse Study Suggests Homotaurine, a compound proven safe for humans in long-term clinical trials, has eased autoimmune responses, brain inflammation, and multiple sclerosis-like symptoms in a mouse model of the disease, a study has found. The findings represent proof-of-principle evidence that homotaurine may represent a new potential class…
November 13, 2018 News by Patricia Inacio, PhD Inflammatory Th17 Cells Seen to Trigger Obsessive Compulsive Disorder in MS Mouse Model The pro-inflammatory Th17 cells that characterize multiple sclerosis (MS) may also underlie symptoms of obsessive-compulsive disorder (OCD), results of a mouse study show. The study, āAuto-Reactive Th17-Cells Trigger Obsessive-Compulsive-Disorder Like Behavior in Mice With Experimental Autoimmune Encephalomyelitis,ā was published in the journalĀ Frontiers in Immunology. “For the first time,…
October 29, 2018 News by Ana Pena PhD Blocking Molecule Evident in Excess in MS Patients Treats Mice with SPMS-like Disease, Study Reports Blocking a molecule that is overly abundant in theĀ nervous system of multiple sclerosis (MS) patients, and has been linked to nerve cell damage in animals, worked toĀ significantly ease inflammation, demyelination, and neurodegeneration in mouse modelsĀ of secondary progressive MS (SPMS), a study reports. Treatment…
October 26, 2018 News by Patricia Inacio, PhD Infection with Common Herpes Virus Speeds MS-like Disease Onset and Progression in Primate Model, Study Reports Infection with theĀ most common member of the herpes virus family, called HHV-6, may pass unnoticed and without symptoms, but the very act of being infected significantly accelerated the development and progression of aĀ multiple sclerosis-like disease in nonhuman primates, a study reports. Its findings support the role of viral infection in…
September 20, 2018 News by Patricia Inacio, PhD Lymphatic Vessels of Brain Carry Messages That Appear to Promote MS, Study Reports Lymphatic vessels, the āroadsā that work to clear waste material from the brain, can also carry messages that direct immune system attacks against myelin, promoting the onset of multiple sclerosis (MS), new study shows. While the identity of these messages remains unknown, the findings suggest that blocking these signals could…
August 24, 2018 News by Patricia Inacio, PhD Cannabidiol Increases Inflammatory Suppressor Cells, New MS Mouse Study Shows Non-psychoactiveĀ cannabidiol (CBD), one of the active compounds in medicalĀ cannabis, significantly reduced clinical signs of multiple sclerosis (MS)-like disease in an experimental autoimmune encephalomyelitis mouse model. Researchers found that CBD promoted the increase of inflammatory-suppressor cells calledĀ myeloid-derived suppressor cells. The findings were reported in the study āCannabidiol Attenuates Experimental Autoimmune…
August 7, 2018 News by Joana Carvalho, PhD Vitamin D3 Insufficiency Increases MS Susceptibility in a Gene and Sex-dependent Manner Vitamin D3 insufficiency increases multiple sclerosisĀ (MS) susceptibility in a gene and sex-dependent manner, a mouse study suggests. The study with that finding, “Sex-Specific Gene-by-Vitamin D Interactions Regulate Susceptibility to Central Nervous System Autoimmunity,” by researchers at the University of Vermont, was published in the journalĀ Frontiers in…
June 6, 2018 News by Patricia Inacio, PhD #CMSC2018 ā Inhibiting Oxidative Stress Enzyme Promotes Resealing of Blood-Brain Barrier in MS Mouse Model Inhibiting an oxidative stress enzyme called myeloperoxidase protects the blood-brain barrier in a mouse model of multiple sclerosis (MS), limiting the migration of immune cells and halting their attack on nerve cells, researchers have found. Disruption of the blood-brain barrier is a hallmark of various disorders, including MS, and when…
January 10, 2018 News by Jose Marques Lopes, PhD Stem Cell Combo Therapy Shows Efficacy in MS Mouse Model, Korean Study Shows A combination therapy of low-dose methylprednisolone and interferon (IFN)-beta-secreting stem cells is effective in a mouse model of multiple sclerosis (MS), a new Korean study suggests. The research, āEffective combination of methylprednisolone and interferon Ī²-secreting mesenchymal stem cells in a model of multiple sclerosis,ā appeared in the…
December 29, 2017 News by Patricia Inacio, PhD Clomipramine, an Antidepressant, Shows Potential in Treating Progressive MS in Early Study Clomipramine, an approved antidepressant, shows potential in treating people with progressive multiple sclerosis (MS) Ā ā a disease form with few treatments ā by protecting nerves from various processes thought to underly progressive MS, early research shows. The lab and animal study, which focused on already-approved treatments, was titled āSystematic…
December 14, 2017 News by Patricia Inacio, PhD Body’s Biological Clock and Time of Day Affects Immune Cells, Mouse Study Shows Researchers further explored how our internal biological clock ā known as circadian rhythm ā influences immune system responses.Ā Disruptions to that rhythm are associated with immune diseases like multiple sclerosis (MS), although in waysĀ not fully understood and, the study suggests, may affect response to treatment. A natural 24-hour cycle that exists…
November 28, 2017 News by Patricia Inacio, PhD Immune Cells Use 2 Entry Points to Overcome Blood-brain Barrier and Attack Myelin in MS Mice Immune cells that destroy myelin in multiple sclerosis (MS) access the brain and spinal cord via two different routes, a new mouse study shows. This suggests that therapies which target these entry routes may shield the brains of MS patients from further damage. The study, āCaveolin1 Is Required for…
November 22, 2017 News by Alice MelĆ£o, MSc Gut Bacteria Contribute to MS Onset and Development, Rutgers Mouse Study Shows Exposure to certain gut bacteria at a young age may cause multiple sclerosis (MS) and fuel its progression, a new mouse study shows. The study, āGut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood,ā appeared in the journal Proceedings of the National…