November 1, 2023 News by Marisa Wexler, MS Immune cell, fat metabolism changes may help explain MS progression More activity among certain immune cells, as well as differences in immune signaling molecules, iron regulation, and fat metabolism, may explain why multiple sclerosis (MS) progresses more over time in some people than in others, researchers report. These findings may help to better understand the molecular mechanisms leading to…
May 22, 2019 News by Joana Carvalho, PhD Reactivation of Ancient Viruses May Be Involved in MS Inflammatory Response, Study Says Reactivation of ancient viruses incorporated into the human genome in the course of evolution may be involved in the acute inflammatory response that is characteristic of multiple sclerosis (MS), a study says. The findings of the study, “Expression of endogenous retroviruses reflects increased usage of atypical enhancers in…
September 23, 2016 News by Patricia Silva, PhD Protein Biomarker Identified for MS May Predict Disease Severity, Treatment Response A newly discovered potential biomarker of multiple sclerosis (MS) may help to distinguish between peopleĀ who will go on to have less severe disease and those in whom the disease will progress,Ā researchers at Linkƶping University in Sweden report. The biomarker’s discovery came through an investigation into the immune system of MS…
February 15, 2016 News by Patricia Silva, PhD MS Relapse, Remission States Seen to Differ in Gene Expression Between Men and Women A Spanish study showed that relapse and remission in multiple sclerosis (MS) states are regulated by small non-coding RNA (sncRNA) molecules inĀ patterns differing between men and women. Scientists have increasingly realized that sncRNAs play an important role inĀ the regulation of gene expression. Various kinds of these RNA molecules, such as…
December 4, 2015 News by Patricia Inacio, PhD Some RRMS and SPMS Patients Share a Similar Gene Expression in Response to IFN Treatment In a new study entitled āTranscriptional response to interferon beta-1a treatment in patients with secondary progressive multiple sclerosis,ā a team of researchers discovered a subgroup of secondary progressive multiple sclerosis patients (SPMS) exhibiting the same gene expression response to interferon (IFN) treatment as patients with relapsing-remitting MS…
November 6, 2015 News by Patricia Inacio, PhD New Insights Into Immune Cells’ Behavior in MS May Lead To New Therapeutic Approach In a recent study entitled āMicroRNA expression profiling of human blood monocyte subsets highlights functional differences,ā a team of researchers discovered a pool of 66 microRNAs that underlie differences in phenotype and function of a group of immune cells with key roles in multiple sclerosis. The study was published…