meta-analysis

S1PR modulators linked to seizure risk in MS trial meta-analysis

People with multiple sclerosis (MS) have a twofold higher risk of seizures compared with the general population, according to pooled data from clinical trials. Among MS patients, treatment with sphingosine-1-phosphate receptor (S1PR) modulators, a class of MS disease-modifying therapies (DMTs) that includes the oral medications Gilenya (fingolimod),…

Sedentary behaviors more common among MS patients: 11 studies

People with multiple sclerosis (MS) engage in significantly more sedentary behaviors ā€” activities like watching TV or using a computer or smartphone versus those requiring physical movement, such as exercise ā€” than do individuals without the progressive disease, according to a pooled analysis of published studies. This effect was…

Noninvasive brain stimulation may help with walking ability: Analysis

A noninvasive brain stimulation technique called transcranial direct current stimulation (tDCS) can significantly improve walking abilities in people with multiple sclerosis (MS), according to a pooled analysis of published studies. The technique was effective when applied to the main brain region called the primary motor cortex, which is involved…

Menopause linked with lower MS relapse rate, increased disability

Women with multiple sclerosis (MS) have significantly lower relapse rates after entering menopause, but disability levels increase significantly in that period, according to a pooled analysis of studies. The findings are consistent with a decrease in immune activity with age and loss of estrogen, leading to fewer disease-related relapses,…

Stem Cell Transplant Found to Reduce MS Relapses, Ease Disability

Autologous hematopoietic stem cell transplant (aHSCT), a procedure that aims to “reset” the immune system, generally reduces disability and relapse rates in people with multiple sclerosis (MS), according to a new meta-analysis. “Current data encourage a broader application of AHSCT for treating patients with MS while still considering…

Beer Consumption May Be Linked to MS Risk: Meta-analysis

Alcohol intake is not significantly associated with an increased risk of developing multiple sclerosis (MS), but specifically drinking beer may elevate the risk, according to a recent meta-analysis. The association, however, was limited by a small number of included studies. “Further large-scale prospective studies should be conducted to verify…

Study: Trigeminal Neuralgia Affects More Than 3% of Patients

Trigeminal neuralgia, a chronic pain condition characterized by shocks or burning sensations in the face, seems to be much more common among people with multiple sclerosis (MS) than in the general population, according to a review of published studies. This condition also is more prevalent in women with…

Anti-CD20 Therapies Show Similar Safety, Efficacy in RRMS

Anti-CD20 antibody therapies that target B-cells are highly effective for reducing the risk of relapses in people with relapsing-remitting multiple sclerosis (RRMS), a new analysis confirms. The analysis did not find any significant differences in efficacy or safety among the anti-CD20 therapies currently approved to treat RRMS, though…

Probiotics Likely To Be of Help With RRMS, Meta-analysis Finds

Probiotic supplements could ease disability, lessen depression, and improve overall health in people with relapsing-remitting multiple sclerosis (MS), according to an analysis of four randomized clinical trials. Physicians working with these patients might recommend “confirmed probiotic supplements” to help manage “MS concerns,” its scientists wrote, while noting that studies…

Primary Headaches Prevalent in MS, Research Reveals

The prevalence of primary headaches ā€” those with no clear cause ā€” is high among patients with multiple sclerosis (MS), a new study suggests. Clinical screening of headache among MS patients could help tailor individualized treatments and ease the impact of the disease for these patients. The study, ā€œ…