October 19, 2022 News by Marisa Wexler, MS SYK Protein Needed for Microglial Cells to Clear Molecular Debris A protein called spleen tyrosine kinase (SYK) is critical for microglia, the brainās immune cells, to clear the toxic debris that accumulates in multiple sclerosis (MS) and other neurological disorders, a mouse model study shows. āWe have discovered a master controller of the cell type and processes that are…
April 12, 2022 News by Marta Figueiredo, PhD 8 More SPMS Patients Cleared for Foralumab Nasal Spray Treatment Based on findings from the first two secondary progressive multiple sclerosis (SPMS) patients givenĀ foralumab nasal spray, an experimental therapy, the U.S. Food and Drug Administration (FDA) has approved starting treatment in up to eight other patients under a special access program. Those enrolled in this intermediate-size expanded access…
March 15, 2022 News by Marta Figueiredo, PhD Foralumab as Nasal Spray Safely, Effectively Treats 1st SPMS Patient Six months of treatment with foralumab, anĀ experimental nasal spray, safely and effectively improved motor and cognitive function while easing immune activation and inflammatory responses in a person with secondary progressive multiple sclerosisĀ (SPMS), Tiziana Life Sciences, the therapyās developer, announced. The patient ā the first with MS to…
August 16, 2019 Columns by Ed Tobias MS Progression’s Speed Tagged to ‘Smoldering’ Brain Inflammation The presence of chronic active lesions in the brain may provide a clue as to how quickly multiple sclerosis (MS) symptoms will progress. Researchers at the U.S. National Institutes of Health (NIH) call these lesions “smoldering inflammation.” Their study, just published in JAMA Neurology, indicates that the more lesions…
June 28, 2016 News by Patricia Silva, PhD MS Progression May Be Tied to Workings of Immune Complement System in Brain Lesions The complement system, a part of our non-adaptable (innate) immune defenses,Ā is activated in lesions inside the brainās gray matter and may well contribute to the relentless progression of multiple sclerosis (MS), researchers report. The findings offer newĀ insights into mechanisms driving the development of this disease ā particularly itsĀ primary progressive forms.
January 29, 2016 News by Patricia Silva, PhD MS Trigger Believed to Lie in Microglial Cells, Scientists Report Researchers have isolated the particular cell types likelyĀ to initiate common brain disorders and diseases, such as multiple sclerosis (MS) and Alzheimer’s disease, a finding thatĀ may point the way to new and targeted treatments. The brain has a complex cellular architecture characterized by a diverse set of cell types that are…