November 20, 2023 News by Marisa Wexler, MS HHV-6A herpes virus tied to more nerve damage before onset of MS Infection with a herpes virus known as HHV-6A is associated with significantly higher levels of the nerve damage biomarker neurofilament light chain (NfL) in the years leading up to multiple sclerosis (MS), a study suggests. “In blood samples from individuals who later developed MS, we could see that antibodies…
May 15, 2023 News by Patricia Valerio, PhD More nerve damage in MS linked to increased microglia activation Increased activation of microglia, the resident immune cells in the brain that contribute to chronic inflammation in multiple sclerosis (MS), is significantly associated with higher levels of neurofilament light chain (NfL) protein, indicating more nerve damage, a study found. Researchers particularly identified strong links between…
May 10, 2023 News by Lindsey Shapiro, PhD Surgery found successful for some MS patients with facial pain Surgical procedures to treat trigeminal neuralgia ā a type of nerve damage that causes facial pain ā may be successful for some people with multiple sclerosis (MS) who fail to respond to medications, a new study found. A more invasive procedure called microvascular decompression, or MVD, had slightly…
October 28, 2022 News by Lindsey Shapiro, PhD #ECTRIMS2022 ā EBV Antibodies Precede Early Nerve Damage Signs An infection with the Epstein-Barr virus (EBV) consistently preceded elevations in neurofilament light chain (NfL), an early biomarker of nerve cell damage, in people who went on to develop multiple sclerosis (MS), new data show. An increase in NfL levels, which is thought to occur before the clinical…
October 4, 2022 News by Marisa Wexler, MS Stem Cell Transplant May Halt Nerve Fiber Damage in RRMS: Study Autologous hematopoietic stem cell transplant (aHSCT) reduces markers of nerve fiber and myelin damage in people with relapsing-remitting MS (RRMS), according to a small study done in Sweden. “We investigated if therapeutic intervention with aHSCT could halt the injurious process leading to tissue damage in MS,” researchers wrote.
July 5, 2022 News by Steve Bryson, PhD Estriol Plus Copaxone May Protect Against Nerve Damage in RRMS Taking the pregnancy hormone estriol in combination with Copaxone (glatiramer acetate) significantly reduced the blood levels of neurofilament light chain (NfL) ā a marker of nerve damage ā in women with relapsing-remitting multiple sclerosis (RRMS), clinical trial data show. These lower NfL levels were significantly associated with a…
September 16, 2021 News by Marisa Wexler, MS Class of Molecules May Offer Opioid Alternative for Treating Pain A class of molecules called positive allosteric modulators, or PAMs, may be useful in treating pain caused by nerve damage ā a common symptom of multiple sclerosis (MS) ā according to a new study that sheds light on how these molecules work. The international team of researchers behind…
July 3, 2019 News by Ana Pena PhD NervGen to Advance NVG-291 as Potential Remyelination Therapy for MS NervGen wants to advance the development of NVG-291, its lead investigational therapy for spinal cord damage, as a potential remyelination treatment for multiple sclerosis (MS), the company announced. Following preclinical data showing that NVG-291 promotes myelin repair and regeneration of damaged nerves in animal models of…
June 24, 2019 News by Marisa Wexler, MS Blocking Sortilin Protein May Be Potential Treatment for Chronic Nerve Pain, Mouse Study Suggests Inhibiting the function of a protein called sortilin ā an important regulator of nerve damage-induced pain in mice ā may represent a potentially effective strategy for treating chronic pain in humans, including those with multiple sclerosis, a study in mice suggests. The researchers say more work is needed…
May 16, 2019 Columns by Tamara Sellman Need to Know: What Is Dysarthria? Editor’s note: “Need to Knowā is a series inspired by common forum questions and comments from readers. Have a comment or question about MS? Visit our forum. This week’s question is inspired by the forum topicĀ “Slurred Speech” from May 14, 2018.
October 2, 2017 Columns by Debi Wilson Combating Muscle Weakness Associated with MS Sometimes walking, even with an assistance device, can be very challenging because of the extreme muscle weakness that I experience. The slow, off-balanced gait that has been my constant companion for many years prior to my 2010 multiple sclerosis (MS) diagnosis is definitely on the decline. Accepting the…
March 13, 2017 News by Patricia Silva, PhD Muscle Health Test Shows Importance of Exercise in Multiple Sclerosis A new test can show how exercise is benefiting people with multiple sclerosis (MS) and other neurological conditions. The evaluation of muscle health inĀ individuals with MS, spinal cord injuries and other severe nerve damage conditions is usually done with magnetic resonance imaging (MRI) and other expensive equipment. Researchers in the…
February 25, 2016 News by Patricia Silva, PhD Peripheral Neuropathy Reversed in Zebrafish After Treatment with 2 Drugs A researcher hasĀ identified two drugs that may be used to reverse peripheral nerve damage, also referred to as peripheral neuropathy, resulting from diseases like multiple sclerosis (MS) and diabetes, the use of chemotherapy in the treatment of some cancers, or traumatic injuries. The researcher,Ā Sandra Rieger, PhD, is an assistant professor…
January 29, 2016 News by Patricia Silva, PhD MS-related Nerve Damage May Be Treatable with Anti-Seizure Drug Researchers from the University College London (UCL)Ā found that the anti-convulsant drug phenytoin protected neural tissue in patients with optic neuritis ā often the first symptom of multiple sclerosis (MS)Ā āĀ a conditionĀ thatĀ causes the nerves carrying information between the eyes and the brain to become inflamed and progressively damaged. The study…
May 14, 2015 News by Patricia Silva, PhD Celiac Disease Found to Be Linked to Increased Risk of Multiple Sclerosis, Nerve Damage A study recently published in the journal JAMA Neurology revealed that celiac disease is linked to a significant increase in the risk of nerve damage. The study is entitled āRisk of Neuropathy Among 28,232 Patients With Biopsy-Verified Celiac Diseaseā and was conducted by researchers…