November 7, 2023 News by Marisa Wexler, MS Blocking NLRP3 inflammasome eases MS severity in mouse model Blocking the activity of a protein complex called the NLRP3 inflammasome lessened disease severity in a mouse model of multiple sclerosis (MS), a study reports. Results point to NLRP3 as a promising target to ease inflammation in people with MS, but additional studies will be needed to determine the…
November 22, 2016 News by Patricia Silva, PhD Australian Researcher Honored for Discovery That May Lead to Anti-Inflammatory Therapy Dr. Rebecca Coll, a young researcher at theĀ University of Queensland Institute of Molecular Bioscience, won theĀ 2016 Research Australia Discovery AwardĀ for her work in identifying promising anti-inflammatory compoundsĀ that are able to block the NLRP3 inflammasome ā a key driver of inflammation.Ā The discovery could greatly benefit patients with inflammatory diseases,…
November 9, 2016 News by Patricia Silva, PhD Gene Test May Predict Which MS Patients Will Respond to Interferon-beta Therapy In multiple sclerosis (MS) patients who do not respond toĀ interferon-beta treatment, autoimmunity may depend on processes that differ from patients helped by this treatmentā a finding that could lead both to better therapies and tests that predict a patient’s likely response. The study, āAn interferon-Ī²-resistant and NLRP3…
December 28, 2015 News by Patricia Silva, PhD Top 10 Multiple Sclerosis Articles of 2015 Multiple Sclerosis News Today has reported the latest therapies, clinical trial developments, and events in multiple sclerosis (MS) on a daily basis throughout the past year. As 2015 comes to an end, hereĀ are the year’s 10 articlesĀ most widely readĀ byĀ Ā Multiple Sclerosis News TodayĀ readers, each with a brief summary of the developments…
December 11, 2015 News by Margarida Azevedo, MSc Cellular ‘On-Off’ Switch May Activate MS Inflammatory Response In a new study, researchers at UT Southwestern Medical CenterĀ inĀ Texas and The Scripps Research Institute in California discovered that the enzyme NEK7, vital to cell division, plays a crucial role in the activation of the NLRP3 inflammasome, essential to the onset of inflammation. This discovery mayĀ have a significant impact…
March 2, 2015 News by admin Multiple Sclerosis Treatments Benefit From Discovery of New Inflammatory Molecule A newly discovered molecule could play a pivotal role in inflammatory diseases, including multiple sclerosis, according to researchers at Trinity College Dublin and the University of Queensland Australia. The study was published in the journal Nature Medicine,Ā and describes aĀ molecule known as MCC950 that can suppress the ‘NLRP3 inflammasome’,…