November 2, 2023 News by Marisa Wexler, MS Circadian rhythm of certain stem cells may offer treatment approach Targeting genes that control the daily activity cycle of cells that are responsible for repairing myelin in the brain and spinal cord may be a useful strategy for treating multiple sclerosis (MS), a new study shows. Findings also point to a potential link between myelin disorders such as MS…
June 27, 2022 News by Marisa Wexler, MS Proteins Called Tenascins Found to Block Myelin Repair in Mouse Model Proteins called tenascins block the regeneration of myelin by modulating the activity of oligodendrocytes, myelin-making cells of the central nervous system, a study in mouse modelsĀ indicates. “Our research results open up new therapeutic approaches for the treatment of demyelinating diseases such as multiple sclerosis,” Juliane Bauch, a researcher at Ruhr-University…
August 27, 2021 News by Marta Figueiredo, PhD Way Seen to Counter Blood-clotting Molecule That Blocks Myelin Repair Blocking a particular receptor protein of the BMP signaling pathway effectively promoted the maturation of myelin-producing cells and myelin repair in two mouse models of multiple sclerosis (MS), a study showed. Notably, these benefits, observed even after disease onset, took place in the presence of fibrinogen, a blood clotting…
March 12, 2021 News by Steve Bryson, PhD Mouse Study Finds Potential Treatment for Myelin Repair for MS, Aging A decline in the activity of the GPR17 gene is responsible for age-related brain deterioration caused by the loss of myelin, a fatty substance that surrounds nerve cells like a sheath, a mouse study discovered. Researchers identified a small molecule that rejuvenated…
February 26, 2021 News by Marisa Wexler, MS #ACTRIMS2021 – Young Brain Fluid (CSF) Rejuvenates Memory in Mice Editorās note: TheĀ Multiple Sclerosis News Today news team is providing in-depth and unparalleled coverage of the virtual ACTRIMS Forum 2021, Feb. 25-27. GoĀ hereĀ to see all the latest stories from the conference. Factors in the cerebrospinal fluid (CSF) surrounding the brain and spinal cord change with age and can affect…
February 23, 2021 News by Diana Campelo Delgado Johns Hopkins Neuroscientist Wins 2020 Barancik Prize for Innovation The 2020 Barancik Prize for Innovation in MS Research has been awarded to neuroscientistĀ Dwight E. Bergles, PhD, a Johns Hopkins University professor,Ā for his work in understanding the function of brain cells in multiple sclerosis (MS). This international prize awards $100,000 to the recipient. Administered by the National MS…
December 8, 2020 News by Forest Ray PhD MS Patient-derived Stem Cells May Be Viable Source for Myelin Repair, Mouse Study Shows Scientists have demonstrated that stem cells derived from the skin cells of people with multiple sclerosis (MS) can grow into normal myelin-producing nerve cells, called oligodendrocytes, in a mouse model of MS. These patient-derived cells migrated throughout the brain of myelin-deficient mice, producing myelin ā the fatty…
December 7, 2020 News by Steve Bryson, PhD Prenatal Stress Linked to Worse MS Outcomes in Adulthood in Mouse Study Exposure to stress before birth can worsen the clinical symptoms of multiple sclerosis (MS) during adulthood, a study in a mouse model of MS suggested. Investigators also found that prenatal stress can change the levels of a protein critical for neurological development, called…
November 4, 2020 News by Steve Bryson, PhD Myelin Restored on Regenerated Optic Nerve Fibers of Mice in Study Using a two-pronged approach, researchers were able to restore myelin on regenerated nerve fibers in a mouse model of optic nerve injury, which has implications for multiple sclerosis (MS) and other diseases associated with myelin loss,Ā a study reported. The study, ā…
October 9, 2020 News by Marta Figueiredo, PhD Simple Sugar Molecule May Be Potential Myelin-repairing Therapy for MS Oral administration of N-acetylglucosamine (GlcNAc) ā a natural simple sugar sold as a dietary supplement ā preventsĀ myelin degeneration and loss of motor function in a mouse model of multiple sclerosisĀ (MS). Myelin,Ā the protective sheath around nerve fibers that helps to speed transmission of signals between nerve cells, isĀ damaged…
August 20, 2020 News by Marta Figueiredo, PhD Cashew Molecule Promotes Remyelination, Halts Disease Progression in MS Mice Anacardic acid, a compound found in cashew nuts, promotedĀ myelinĀ regeneration and eased neuronal damage and disability in two mouse models of multiple sclerosisĀ (MS). These protective effects were associated with maturation of myelin-producing cells and production of IL-33, an immune-related molecule with a neuroreparative role in the central…
February 28, 2020 News by Ana Pena PhD #ACTRIMS2020 – Remyelination in Adult Animal Brains Possible via Cell Transplant, Study Says Transplanting humanĀ glial progenitor cells (GPCs) ā brain cells able to generate myelin-producing cells ā effectively led to remyelination in the brains of adult mice with myelin disorders, a study found. These results were presented atĀ the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum 2020, running…
February 26, 2020 News by Margarida Azevedo, MSc Potential Therapy, Anavex 2-73, Shows Ability to Protect Neurons and Promote Myelin in Early Tests Anavex Life Sciences‘ investigational therapy Anavex 2-73 (blarcamesine) showed an ability to protect, repair, and induce the formation of oligodendrocytes ā the cells that produce the protective myelin layer around neurons ā in early cell testing, researchers reported. These findings, which further establish the therapy’s potential as a treatment…
January 14, 2020 News by Patricia Inacio, PhD New Mechanism Boosting Myelin Regeneration May Ease MS Symptoms, Mouse Study Shows Blocking a protein called PAR1 may enhance the regeneration of myelin, the protective fatty layer that covers nerve fibers and isĀ damaged in multiple sclerosis (MS), a mouse study shows. Therapeutic targeting of PAR1 may promote remyelination and delay MS progression, according to the study, āBlocking the Thrombin Receptor…
October 14, 2019 News by Marisa Wexler, MS Metformin Works to Promote Remyelination in Ways Similar to Fasting, Study Says Metformin, a common diabetes treatment that works to mimic dietary fasting, was seen to promote remyelination in the stem cells of elderly rats, suggesting it may be useful in treating multiple sclerosis. “Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells” was published in…
October 10, 2019 News by Marta Figueiredo, PhD Blocking LRP1 May Halt Inflammation, Promote Remyelination, Mouse Study Suggests Blocking production of the low-density lipoprotein receptor-related protein 1 (LRP1) ā involved in inflammatory and immune responses ā specifically in myelinĀ repair cells halts neuroinflammation and promotes myelin repair, a preclinical study shows. These results, fromĀ two mouse models of multiple sclerosis (MS), shed light on the underlying mechanisms…
September 10, 2019 News by Joana Carvalho, PhD NervGen Planning Clinical Trials of NVG-291, Peptide That Might Promote Myelin Repair NervGen PharmaĀ announced plans to open clinical trials evaluating the potential of its lead candidate NVG-291 to treat multiple sclerosis (MS) and spinal cord injury. NVG-291 is an investigational peptide that has shown an ability to stimulate nerve regeneration following an injury in several animal models of disease.
September 24, 2018 News by Jose Marques Lopes, PhD Oligodendrocytes, Cells That Produce Myelin, Can Be Generated from Astrocytes, Study Reports A molecule known as Sox10 enables brain cells called astrocytes to convert into myelin-forming oligodendrocytes, a new study in mice reports. The findings suggest an approach for myelin repair in patients with multiple sclerosis (MS) and similar disorders, its researchers said. The study, āIn vivoĀ conversion of…
July 19, 2018 News by Jose Marques Lopes, PhD Blocking Protein Receptor Called M3R Seen to Promote Remyelination in Mice Model, Study Reports Blocking a protein receptor called muscarinic type 3 (M3R) could be an effective way to promote remyelination in multiple sclerosis (MS) patients, according to aĀ State University of New York at Buffalo (UB) study in mice. The research, āMuscarinic receptor M3R signaling prevents efficient remyelination by…
May 10, 2018 News by Jose Marques Lopes, PhD Molecule Whose Fragments Appear to Block Myelin Repair Identified in Study A molecule responsible for preventing the repair of white matter in the brain, a process critical to treatingĀ multiple sclerosis (MS) and cerebral palsy, has been identified. The research, āA TLR/AKT/FoxO3 immune-tolerance like pathway disrupts the repair capacity of oligodendrocyte progenitors,ā was published in The Journal…
August 29, 2017 News by Patricia Inacio, PhD Pancreas Secretes Factor That Can Rejuvenate Damaged Neuron Coating, Mouse Study Reports A substance that the pancreas secretes can promote the regeneration of the protective nerve-cell coating that is damaged in multiple sclerosis, a mouse study shows. The substance isĀ fibroblast growth factor 21, or FGF21. It promotes remyelination, the renewal of the myelin sheath protecting the central nervous system, according to the…
August 21, 2017 News by Patricia Silva, PhD Mouse and Human Myelination Research Might Improve Success Rates for New MS Treatments of the neurons.
February 4, 2016 News by Margarida Azevedo, MSc Experimental MS Therapy Seen to Promote Myelin Regeneration in Preclinical Study RegeneRx Biopharmaceuticals, Inc.,Ā announced the publication of a research article detailing the process by whichĀ Thymosin beta 4 (TĪ²4), the company’s novel therapeutic peptide, effectively promoted the remyelination process in two separate animal models commonly used for multiple sclerosis (MS) research. The article, āThymosin beta4 promotes oligodendrogenesis in the demyelinating…
December 30, 2015 News by Patricia Silva, PhD NIH Grant to Advance Multiple Sclerosis Therapy Targeting Remyelination Novoron Bioscience, Inc., a biotech company focused on developing therapies for disorders of the central nervous system, recently announced that it has received a $680,000 National Institutes of Health (NIH) grant to assess the potential of a new therapeutic approach to induce remyelination in multiple sclerosis (MS). MS is…