Umbilical Cord Stem Cells Work to Restore Immune System Balance in Early Study

Joana Fernandes, PhD avatar

by Joana Fernandes, PhD |

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immune system and stem cells

DamagingĀ immune system defects seenĀ in patients with multiple sclerosis (MS) can be repaired using a simple stem cell approach, according to a new study by researchers in China and the U.S.

The study, ā€œUmbilical Cord-Derived Mesenchymal Stem Cells Reversed The Suppressive Deficiency Of T Regulatory Cells From Peripheral Blood Of Patients With Multiple Sclerosis In A Co-Culture ā€“ A Preliminary Study,ā€ was published in the journal Oncotarget.

Although the origin of MS remains elusive, immune system attacks against myelin is aĀ knownĀ hallmark of the disease. In MS patients,Ā immune system cells called T-cells penetrate the brain and react against the myelin coating that protects and supports neurons. Essentially, the T-cells’ activity is Ā unregulated, something usuallyĀ mediated by T regulatory cells (Tregs), and contributes toĀ their abnormal aggressiveness.

One possible way to restore T-cell regulation is by using mesenchymal stem cells or MSCs (stem cells are immature cells that can become any type of cell in the body). MSCs are a type of stem cell found in the bone marrow, and have been shown to stimulate the presence of Tregs, thereby controlling the activity of T-cells.

The human umbilical cord has stem cells equivalent to MSCs, called UC-MSCs ā€” these cells are more stable, induce lower immune responses, and have higher expansion ability compared toĀ MSCs.

To understand whether these umbilical cord stem cells could restore the regulation of the immune system in MS, researchers cultured UC-MSCs together with immune system cells present in the blood of MS patients and healthy subjects.

UC-MSCs were obtained from discarded human umbilical cords, which offer an abundant and noninvasive source of these cells, and the blood cells from 12 relapsing-remitting multiple sclerosis (RRMS) patients (mean age 53.75) and 10 healthy donors (mean age 28.38).

Researchers observed that the presence of UC-MSCs significantly increased the numberĀ of Tregs among resting T-cells from the MS patients. UC-MSCs were also able to restoreĀ the regulatory activity of Tregs, probably by stimulating the production of specific proteins, called cytokines, that controlĀ T-cell activity.

These results, overall, demonstrated that umbilical cord stem cells can effectively reduce abnormal immune system activity in MS.

ā€œWe report for the first time that the intrinsic Treg defect in MS can be repaired in vitro using a UC-MSC-mediated immune modulation,ā€ the researchersĀ concluded. ā€œOur studies provide valuable preliminary in vitro data to support the development of functionally normalized Tregs ā€¦ from individual patients with autoimmune diseases using a simple UC-MSC-based priming approach and may offer new therapeutic treatments for MS and other autoimmune diseases.ā€