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Researchers Share Strategies to Improve Clinical Trial Recruitment

Publicity in national news outlets and an online self-screening questionnaire helped improve recruitment for a clinical trial in secondary progressive multiple sclerosis (SPMS), a new study highlights. “We have described our experience of recruiting participants with SPMS into two large RCTs [randomized clinical trials] in order to identify areas…

Eye Scans May Help to Diagnose MS in Children

A machine learning approach based on eye scans was employed by researchers to diagnose multiple sclerosis (MS) in children with up to 80% accuracy. Optical coherence tomography (OCT) scans also provided enough data to diagnose other demyelinating diseases with 75% accuracy. OCT is an imaging tool that uses…

Study Uncovers How Interferon-beta May Be Helping to Treat MS

Researchers have discovered how interferon-beta, a common treatment for multiple sclerosis (MS), may be effective for people with the disease. Specifically, they found that red blood cells from MS patients have an unusually high ability to bind molecules that contribute to disease-related impairments in neuronal health and myelin repair,…

CNM-Au8 Lessens Vision Problems in RRMS Patients in Phase 2 Trial

CNM-Au8, Clene Nanomedicine’s experimental oral therapy, safely and effectively improves vision and neurological function in adults with stable relapsing-remitting multiple sclerosis (RRMS) and disease-related visual impairment. Those are the findings of the VISIONARY-MS Phase 2 clinical trial (NCT03536559), a proof-of-concept study that investigated CNM-Au8 in people with…

RRMS Onset Taking Place at Older Ages Over Past 50 Years

The first symptoms of relapsing-remitting multiple sclerosis (RRMS) have been appearing increasingly later in life, according to a Spanish study covering nearly five decades. From the 1970s through the 2010s, the average age at disease onset rose by more than 10 years in both men and women, its researchers…

Early Detection of Pseudobulbar Affect May Help Ease MS Symptom

In its inaugural issue, a publication from The Gerontological Society of America provides information about recognizing and managing pseudobulbar affect — uncontrolled outbursts of crying or laughing that the authors say are one of the most “underrecognized and undertreated” symptoms of multiple sclerosis (MS) and other neurological conditions. The…

Exergaming May Be Better Than Other Exercises, But Study Needed

Virtual reality exergames — immersive video games whose play involves physical exercise — may be better than conventional exercise at easing certain symptoms of multiple sclerosis (MS), such as balance and upper limb function, a review of published studies suggested. However, differences among the evaluated studies — in matters…

PAS002 Vaccine Shows Efficacy in MS Mouse Model

Pasithea Therapeutics investigational multiple sclerosis vaccine, PAS002, effectively delayed disease onset and reduced disease severity in a mouse model of the neurodegenerative condition, according to data from a preclinical study. The vaccine, which is designed to promote immune tolerance to a specific myelin protein, also reduced the severity…

Adding Nursing Care in MS May Ease Patient Depression, Anxiety

Adding a specialized nurse practitioner (NP) to a neurologist-based standard care team was found to significantly lessen depression and anxiety in patients with multiple sclerosis (MS), according to data from a six-month study in Canada. People with multiple sclerosis — dubbed “PwMS” by researchers — who received the add-on…

New 3D Brain Map May Help in Disease Management: Study

A team of researchers has created a three-dimensional (3D) map of the lymphatic vessels that drain the brain, and demonstrated that these vessels are organized similarly in mice and in humans. The researchers propose measuring these vessels using MRI scans could “allow longitudinal imaging of disease progression that may be…

Stem Cell Transplant Found to Reduce MS Relapses, Ease Disability

Autologous hematopoietic stem cell transplant (aHSCT), a procedure that aims to “reset” the immune system, generally reduces disability and relapse rates in people with multiple sclerosis (MS), according to a new meta-analysis. “Current data encourage a broader application of AHSCT for treating patients with MS while still considering…

Astrocytes May Promote MS Inflammation via D2 Receptors

A set of receptors involved in dopamine signaling may play a key role in the activation of astrocytes, nerve support cells that contribute to the inflammation that drives multiple sclerosis (MS), according to a study in a mouse model of the neurodegenerative disease. Mice lacking these receptors — called dopamine…

Ocrevus Outperforms Rebif in Preventing Myelin Loss in Trial

Two years of treatment with Ocrevus (ocrelizumab) outperformed Rebif (interferon beta-1a) at preventing myelin loss in people with relapsing multiple sclerosis (MS), according to a new analysis of data from the OPERA II clinical trial. Ocrevus’ protection against demyelination was observed both in MS lesions,…

Vagus Nerve Stimulation Boosts Motor Learning in Mouse Model

Providing electrical stimulation to the vagus nerve, a large nerve that plays important roles in modulating nonconscious bodily processes like digestion and heart rate, can improve motor learning in mice, a new study shows. The approach specifically helped the animals learn motor tasks faster and achieve better performance levels in…

No Link Between MS Severity, Vitamin D-related Mutations: Study

A number of genetic variations related to vitamin D metabolism were not significantly associated with the severity of multiple sclerosis (MS), according to a recent study. The study, “Role of Multiple Vitamin D-Related Polymorphisms in Multiple Sclerosis Severity: Preliminary Findings,” was published in Genes. In MS, the body’s immune…

Questions to Ask Your Doctor If You’re Newly Diagnosed

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We consulted some of our community contributors at MS News Today and came up with 12 questions people should consider asking their doctors after an MS diagnosis.

Check it out by clicking here.

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