ACTRIMS

Bazedoxifene, a medication that alters the activity of the sex hormone estrogen, was safe and well-tolerated but did not promote myelin repair in women with multiple sclerosis (MS) in a Phase 2 clinical trial. The findings come from the ReWRAP study (NCT04002934) and were presented last week at…

Better adherence to a Mediterranean-like diet may help prevent disability worsening in people with early multiple sclerosis (MS), in part by slowing biological aging, according to data from a new study. The findings suggest that diet, biological age, and disability are closely connected and that lifestyle changes could…

The investigational BTK inhibitor tolebrutinib did not lower the risk of confirmed disability progression compared with placebo in people with primary progressive multiple sclerosis (PPMS), failing to meet the main goal and several key secondary goals of the Phase 3 PERSEUS trial. It did, however, show signs of…

The complement system — part of the immune system that helps defend against infections — may play a key role in age-related disease progression in multiple sclerosis (MS), according to findings from a mouse study. In fact, blocking a complement protein called C3 reduced disease severity in older mice…

The investigational BTK inhibitor fenebrutinib was as effective as the approved therapy Ocrevus (ocrelizumab) at reducing the risk of disability progression in people with primary progressive multiple sclerosis (PPMS), meeting the main goal of a Phase 3 trial. According to fenebrutinib’s developer, Genentech, the therapy is the…

Researchers have developed a mouse model designed to reflect the disability worsening that occurs in the absence of relapses for many people with multiple sclerosis (MS). The model shows key features of this form of disease worsening, known as progression independent of relapse activity (PIRA), including immune cell clusters…

A three-year study of GA Depot, a monthly injection for primary progressive multiple sclerosis (PPMS), found that most patients experienced no disability progression, with some even showing slight improvements in mobility. These interim results from a Phase 2a clinical trial will be presented tomorrow by developer Mapi Pharma…

Researchers and clinicians are gathering in San Diego and online for the 11th annual Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum, a three-day meeting focused on multiple sclerosis (MS) research and care. ACTRIMS 2026, being held Feb. 5-7 at the Marriott Marquis San Diego…