Approved Treatments for Multiple Sclerosis
There is no cure for multiple sclerosis (MS) yet, but a number of treatment options, particularly for the relapsing-remitting form of the disease, have been approved to help manage symptoms and slow progression. There are two basic treatment approaches to treating MS: immunomodulation therapies, which can control the inflammation of myelin sheaths and help restore the central nervous system, and supportive therapies, which can help manage symptoms and exacerbations to help patients lead as normal a life as possible.
Learn more about some of the approved treatments used to treat MS and its symptoms below.
Aubagio (teriflunomide) is an active metabolite of the compound leflunomide and is a pyrimidine synthesis inhibitor. It is an oral formulation that has immunomodulatory properties, which can mitigate the rate and extent of damage caused to nerve fibers in neurodegenerative conditions like MS.
Avonex (interferon beta-1a) is an injectable medication approved for patients with relapsing forms of MS who have had a first attack and show lesions on an MRI. Administered by injection into the muscle, it is designed to help reduce the number of flare-ups and MS disease progression.
Betaseron (interferon beta 1b) is an anti-inflammatory therapy indicated for patients with relapsing-remitting MS. Similar to other interferon beta 1b formulations, Betaseron reduces inflammation in the nervous system.
Copaxone (glatiramer acetate injection) is a disease-modifying therapy approved for the treatment of relapsing forms of MS, including CIS, relapsing-remitting MS, and active secondary progressive MS. The generic form is Glatopa.
Decadron (dexamethasone) is an oral glucocorticosteroid that helps in treating the acute exacerbations associated with relapsing forms of MS. It is believe that Decadron’s mechanism of action is mainly anti-inflammatory in nature, and that it also works as an immunosuppressor.
Extavia (interferon beta 1b) is a subcutaneous therapy intended to reduce the number of exacerbations in patients with relapsing-remitting MS. It is also prescribed for people with a single clinical episode related to MS, consistent with MRI results.
Gilenya (fingolimod) is an oral disease-modifying therapy indicated for patients with relapsing forms of MS, including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive MS. It works by modulating the immune response to reduce disease exacerbations, delaying progression and accumulation of disability.
Kesimpta (ofatumumab) is approved to treat adults with relapsing forms of MS. It is the first MS therapy targeting B-cells that can be self-administered at home. The treatment is given once per month via under-the-skin injection using an autoinjector pen called the Sensoready Pen.
Lemtrada (alemtuzumab) is a disease-modifying treatment designed to slow down the progression of relapsing-remitting MS. It is intended to lower the relapse rate and treat the symptoms of MS. Its use is recommended in patients who have had an inadequate response to two or more MS therapies.
Mavenclad (cladribine) is a disease-modifying and short-course oral tablet treatment for people with active and relapsing forms of MS. The treatment is typically recommended for patients who failed to respond to, or were unable to tolerate, other MS therapies.
Mayzent (siponimod) is an oral treatment used to treat relapsing forms of MS, including active secondary progressive MS. It works by binding to the sphingosine-1-phosphate (S1P) receptors on the outside of immune cells, blocking their normal action. Mayzent keeps the immune cells trapped in the lymph nodes, slowing disease progression.
Novantrone (mitoxantrone for injection concentrate) is an intravenously delivered synthetic molecule for the treatment of MS. It is indicated to reduce neurological disability and frequency of relapses in patients with worsening relapsing-remitting MS, secondary progressive MS, and progressive-relapsing MS.
Ocrevus (ocrelizumab) is a humanized monoclonal antibody developed to treat MS. It is the first therapy approved in both the U.S. and Europe to treat both relapsing forms of MS and primary progressive MS, the latter of which had no approved treatments previously in the U.S. or the EU.
Plegridy (peginterferon beta-1a) is approved to treat relapsing forms of MS. It is a “pegylated” form of interferon beta-1a that allows for less frequent dosing. It is an injectable formulation, administered under the skin once every two weeks.
Ponvory (ponesimod) is a sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator approved in the U.S. and EU for the treatment of relapsing forms of MS. It is a once-daily oral therapy. Beginning treatment may result in a decrease in heart rate, so first-dose monitoring is recommended in patients with certain preexisting cardiac conditions.
Rebif (interferon beta-1a) is an under-the-skin injection therapy indicated for relapsing forms of MS. It is designed to reduce the frequency of disease exacerbations and delays the accumulation of physical disability caused by these flares.
Solu-Medrol (methylprednisolone) is a corticosteroid with anti-inflammatory action. Administered via intravenous or intramuscular routes, it is used to treat acute exacerbations in patients with MS.
Tecfidera (dimethyl fumarate) is an oral formulation approved for relapsing forms of MS. Several generic forms of dimethyl fumarate also have been approved in the U.S. Tecfidera is an immunomodulatory therapy that has been shown to reduce relapse rates and delay progression.
Tysabri (natalizumab) is an antibody-based therapy approved to treat adults with relapsing forms of MS. It can be administered by intravenous or subcutaneous injection at a dosage of 300 mg every four weeks, but it is only approved in the intravenous formulation in the U.S.
Vumerity (diroximel fumarate) is an oral treatment approved for people with relapsing forms of MS. It is available as delayed-release capsules. Vumerity is made of a small molecule called diroximel fumarate, which is an inactive prodrug that is converted into its active form, monomethyl fumarate, inside the body.
Zeposia (ozanimod) is a treatment developed to treat adults with relapsing forms of MS. The treatment comes in 0.92 mg capsules that patients take by mouth once a day. Zeposia belongs to a class of medications known as selective sphingosine 1-phosphate (S1PR1) and 5 (S1PR5) receptor modulators.
Zinbryta (daclizumab) is a humanized monoclonal antibody approved for relapsing forms of MS in the U.S. and in Europe. In the high-yield formulation, Zinbryta is intended to be administered under the skin once every four weeks.