Approved Treatments for Multiple Sclerosis

Avonex

Avonex (interferon beta-1a) is an injectable medication approved for patients with relapsing forms of MS. Administered by injection into the muscle, it is designed to help reduce the number of flare-ups and brain lesions and delay disability progression.

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Betaseron

Betaseron (interferon beta-1b) is an anti-inflammatory therapy indicated for patients with relapsing-remitting MS, active secondary progressive MS, and clinically isolated syndrome. Administered via subcutaneous injection, it is similar to other interferon beta formulations in that it reduces inflammation in the nervous system.

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Extavia

Extavia (interferon beta-1b) is a subcutaneous therapy intended to reduce the number of exacerbations and prevent the development of new brain lesions in patients with relapsing forms of MS.

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Plegridy

Plegridy (peginterferon beta-1a) is approved to treat relapsing forms of MS. It is a “pegylated” form of interferon beta-1a that allows for less frequent dosing.  It is an injectable formulation, administered under the skin once every two weeks.

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Rebif

Rebif (interferon beta-1a) is an under-the-skin injection therapy indicated for relapsing forms of MS. It is designed to reduce the frequency of disease exacerbations, delay the accumulation of physical disability, and prevent the development of new lesions.

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Gilenya

Gilenya (fingolimod) is an oral disease-modifying therapy indicated for patients with relapsing forms of MS, including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive MS. It works by modulating the immune response to reduce disease exacerbations, delay the accumulation of disability, and prevent new lesions from forming.

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Mayzent

Mayzent (siponimod) is an oral treatment used to treat relapsing forms of MS. It works by binding to the sphingosine-1-phosphate (S1P) receptors on the outside of immune cells, blocking their normal action. Mayzent keeps the immune cells trapped in the lymph nodes, slowing disease progression.

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Ponvory

Ponvory (ponesimod) is a sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator approved for the treatment of relapsing forms of MS. It is a once-daily oral therapy used to lower relapse rates and slow the development of brain lesions.

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Zeposia

Zeposia (ozanimod) is a treatment developed to treat adults with relapsing forms of MS. It helps to reduce relapse rates and the development of new brain lesions.

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Bafiertam

Bafiertam (monomethyl fumarate) is a disease-modifying therapy for relapsing forms of MS. While the exact mechanism of action of Bafiertam is not fully known, the medication’s active ingredient, monomethyl fumarate (MMF), is broadly thought to reduce the inflammation that drives MS.

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Tecfidera

Tecfidera (dimethyl fumarate) is an oral formulation approved for relapsing forms of MS. It is an immunomodulatory therapy that has been shown to reduce relapse rates, delay progression, and slow the development of brain lesions.

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Vumerity

Vumerity (diroximel fumarate) is an oral treatment approved for people with relapsing forms of MS. It is available as delayed-release capsules. Vumerity is made of a small molecule called diroximel fumarate, which is an inactive prodrug that is converted into its active form, monomethyl fumarate, inside the body.

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Kesimpta

Kesimpta (ofatumumab) is approved to treat adults with relapsing forms of MS. It is the first MS therapy targeting B-cells that can be self-administered at home. The treatment is given once per month via under-the-skin injection using an autoinjector pen called the Sensoready Pen. It is also available in pre-filled syringes.

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Ocrevus

Ocrevus (ocrelizumab) is a humanized monoclonal antibody developed to treat MS. It is the first therapy approved in the U.S. to treat both relapsing forms of MS and primary progressive MS, the latter of which had no approved treatments previously.

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Aubagio

Aubagio (teriflunomide) is an active metabolite of the compound leflunomide and is a pyrimidine synthesis inhibitor. It is an oral formulation that has immunomodulatory properties, which can mitigate the rate and extent of damage caused to nerve fibers in neurodegenerative conditions like MS.

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Copaxone

Copaxone (glatiramer acetate injection) is a disease-modifying therapy approved for the treatment of relapsing forms of MS, including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive MS. Generic forms are also available.

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Lemtrada

Lemtrada (alemtuzumab) is an approved antibody-based therapy for relapsing forms of MS used to reduce relapses and prevent disability progression. Because Lemtrada can increase the risk of severe complications, it is generally recommended in the U.S. for patients who have failed to respond to at least two other MS treatments.

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Mavenclad

Mavenclad (cladribine) is a disease-modifying and short-course oral tablet treatment for people with active and relapsing forms of MS. The treatment is typically recommended for patients who failed to respond to, or were unable to tolerate, other MS therapies.

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Mitoxantrone

Mitoxantrone hydrochloride is an infusion medication used to slow disability progression and decrease the risk of relapses in people with relapsing forms of MS. It also is approved for nonactive SPMS. Originally sold under the brand name Novantrone, the therapy is available only as a generic medication.

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Tysabri

Tysabri (natalizumab) is an antibody-based therapy approved to treat adults with relapsing forms of MS. It is available in the U.S. only through a restricted distribution program called TOUCH Prescribing Program because of its risk of progressive multifocal leukoencephalopathy.

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Dexamethasone

Dexamethasone is a man-made glucocorticoid with powerful anti-inflammatory and immunosuppressive properties that is often used in the treatment of inflammatory and autoimmune disorders such as MS. Dexamethasone works mainly by binding to glucocorticoid receptors in immune cells, prompting immune cells to take on a less inflammatory state.

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Methylprednisolone

Methylprednisolone is a man-made molecule that mimics cortisol and works mainly by dampening the inflammatory activity of immune cells. Like other corticosteroids, methylprednisolone works mainly by dampening the inflammatory activity of immune cells, decreasing their numbers and the pro-inflammatory signaling molecules they produce.

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Prednisone

The man-made medication exerts its effects in MS mainly by binding to protein receptors on the surface of immune cells, thus dampening the inflammatory activity of these cells. Prednisone also reduces the permeability of blood vessels, which also limits the number of immune cells that reach the brain and cause damage.

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Acthar Gel

Acthar Gel (repository corticotropin injection) is an injectable therapy used to manage acute relapses in MS. The treatment is usually considered for MS patients who have had inadequate responses, or cannot tolerate, corticosteroids.

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Purified Cortrophin Gel

Cortrophin Gel (repository corticotropin injection) is an injectable therapy approved to treat acute relapses. Cortrophin Gel’s mechanism of action is not fully known, but it is thought to work mainly by increasing cortisol levels, thus reducing the inflammatory autoimmune attack that drives MS exacerbations.

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Ampyra

Ampyra (dalfampridine) is an oral medication used to improve walking ability in people with MS. The treatment’s mechanism of action is not completely understood, but the medication is known to block the activity of potassium channels, thus improving the conduction of electrical signals in damaged neurons.

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Botox

Botox (onabotulinumtoxinA) is an injectable treatment approved to ease spasticity in MS. The therapy also is approved for neurogenic detrusor overactivity in MS, when nerve damage causes the muscle around the bladder to be overactive. Although Botox can ease these symptoms of MS, it does not alter the progression of the disease.

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Dysport

Dysport (abobotulinumtoxinA) has been approved to treat upper and lower limb spasticity in adults (a common symptom of MS) and is currently being studied as a treatment for overactive bladder in MS patients. It is administered as an injection directly into the muscle.

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PoNS Device

The Portable Neuromodulation Stimulator, or PoNS, is an approved noninvasive medical device used in combination with physical rehabilitation to reduce MS-associated walking problems. The electrical signals delivered through the device are thought to create a natural flow of stimuli from the tongue to the brain, promoting neuroplasticity.

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