Prozac (fluoxetine) is used to treat depression, obsessive-compulsive disorder, panic attacks, and some eating disorders. It can also be used off-label to treat fatigue caused by multiple sclerosis (MS). Prozac is an antidepressant from the selective serotonin reuptake inhibitors (SSRIs) group. In a positive way, it effects chemicals in the brain that may be unbalanced in people with depression, anxiety, or similar conditions.

Prozac (fluoxetine) for Depression in Multiple SclerosisFluoxetine comes in different formats (tablet, delayed-release capsule, and liquid solution). It’s taken once or twice a day at the same time, with or without food. It may take four or five weeks before the full benefit of the drug is felt. Patients should not stop taking the drug suddenly because sudden discontinuation can cause withdrawal symptoms, such as mood changes, dizziness, numbness or tingling in the hands or feet, anxiety, confusion, headache, tiredness, and sleeping disorders.

Though the drug is effective, some common side effects may include sleep problems (insomnia) and strange dreams, headache, dizziness, vision changes, tremors or shaking, emotional disorders, pain, tiredness, gastric disorders, dry mouth, sweating, hot flashes, eating disorders, flu-like symptoms, decreased sex drive, impotence, or difficulty reaching orgasm.

Prozac comes with a black box warning that appears on the prescription drug label to draw attention to serious or life-threatening risks. Taking Prozac can increase suicidal thoughts and behaviors in people who struggle with major depression and other psychiatric disorders, especially during the first months of treatment or following changes in dosage.

An FDA approved generic version of Prozac is available.

Note: Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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  1. http://www.nationalmssociety.org/Treating-MS/Medications/Prozac
  2. https://www.drugs.com/prozac.html
  3. https://medlineplus.gov/druginfo/meds/a689006.html
  4. http://www.fda.gov/downloads/ForConsumers/ConsumerUpdates/UCM107976.pdf
  5. https://online.epocrates.com/drugs/1154/Prozac
  6. https://www.drugs.com/availability/generic-prozac.html