April 18, 2024 News by Marisa Wexler, MS AAN 2024: Sustained myelin, nerve cell gains with long-term CNM-Au8 Long-term treatment with Clene Nanomedicine‘s experimental oral therapy CNM-Au8 led to signs of sustained improvements in nerve and myelin health for people with relapsing-remitting multiple sclerosis (RRMS) over three years, according to new data from the VISIONARY-MS clinical trial. The findings continue to support Clene’s plans to…
January 9, 2024 News by Lindsey Shapiro, PhD CNM-Au8 leads to clinical gains for RRMS patients in extension study Daily treatment withĀ CNM-Au8 led to sustained improvements in vision and cognition for people with relapsing-remitting multiple sclerosis (RRMS), according to nearly three years of follow-up in the VISIONARY-MS trial and its open-label extension (OLE). Developer Clene Nanomedicine plans to present full trial results at the upcoming ACTRIMS…
May 30, 2023 News by Lindsey Shapiro, PhD Clene wins grant to develop CNM-Au8 for progressive MS The National Multiple Sclerosis Society has awarded Clene Nanomedicine a grant to advance its treatment candidate CNM-Au8 for people with nonactive, progressive forms of multiple sclerosis (MS). The funding comes from the MS Society’s Fast Forward Program, which supports commercial organizations developing promising new MS therapies,…
March 1, 2023 News by Marisa Wexler, MS ACTRIMS 2023: CNM-Au8 bound for Phase 3 testing after positive data Treatment with the experimental oral suspension therapy CNM-Au8 led to improvements in measures of vision, cognitive and motor function, and brain health for people with multiple sclerosis (MS), according to data from the proof-of-concept VISIONARY-MS trial. Bolstered by these positive results,Ā Clene Nanomedicine is planning to launch a…
February 14, 2023 News by Marisa Wexler, MS CNM-Au8 preserves white matter in RRMS patients’ brains: Phase 2 trial Treatment withĀ CNM-Au8, anĀ experimental oral liquid therapy, led to statistically significant improvements in the health of connections between brain regions for people with stable relapsing-remitting multiple sclerosis (RRMS). That’s according to new MRI data from the Phase 2 VISIONARY-MS trial (NCT03536559), which tested CNM-Au8 against a placebo in…
August 17, 2022 News by Marta Figueiredo, PhD CNM-Au8 Lessens Vision Problems in RRMS Patients in Phase 2 Trial CNM-Au8, Clene Nanomedicineās experimental oral therapy, safely and effectively improves vision and neurological function in adults with stable relapsing-remitting multiple sclerosis (RRMS) and disease-related visual impairment. Those are the findings of the VISIONARY-MS Phase 2 clinical trial (NCT03536559), a proof-of-concept study that investigated CNM-Au8 in people with…
February 15, 2022 News by Steve Bryson, PhD VISIONARY-MS Trial of CNM-Au8 to End Early Due to Pandemic VISIONARY-MS, a Phase 2 clinical trial evaluating the safety and effectiveness of CNM-Au8 in people with relapsing multiple sclerosis (MS) with disease-related visual impairment, will conclude early due to COVID-19 pandemic-related challenges. The release of trial data is expected in the second half of this year, according to…
August 6, 2021 News by Steve Bryson, PhD CNM-Au8 Seen to Raise Energy Metabolism of Brain in RRMS Trial Cleneās investigational oral therapy CNM-Au8 improved energy metabolism in the brain of adults with relapsing-remitting multiple sclerosis (RRMS), according to top-line results from the REPAIR-MS trial. This open-label Phase 2 pilot study (NCT03993171), taking place in Texas, is running in parallel with REPAIR-PD, another Phase 2…
January 20, 2021 News by Marisa Wexler, MS Clene Awaits US Patent Covering Gold Nanocrystals’ Use in Treating MS Clene Nanomedicine has been notified it will be given a U.S. patent, as requested, covering an invention using the company’s already patented gold nanocrystals for the treatment of multiple sclerosis (MS). A Notice of Allowance was received by the company. These notices are issued by the U.S. Patent…
March 16, 2020 News by Ana Pena PhD #ACTRIMS2020 – CNM-Au8 a Potential ‘Breakthrough’ in MS Therapy, Clene CMO Says An investigational therapy that uses nanocrystals of gold to help the brain repair itself represents a breakthrough in the multiple sclerosis (MS) field, says Clene Nanomedicine‘s chief medical officer Robert Glanzman. Glanzman, MD, recently presented promising results at the ACTRIMS Forum 2020 indicating that Clene’s lead…
February 28, 2020 News by Ana Pena PhD #ACTRIMS2020 – Early Trial Data Support CNM-Au8 Improving Vision, Physical Abilities Clene Nanomedicine shared early results of the VISIONARY-MS trial, suggesting that CNM-Au8 āĀ an investigational remyelinating therapy ā leads to “notable” trends in better vision, as well as benefits in mobility and manual function in relapsing multiple sclerosisĀ (MS) patientsĀ with chronic vision problems.
February 13, 2020 News by Ana Pena PhD Gold Nanocrystals in Phase 2 Testing Show ‘Robust’ Remyelination Potential in Animal Models Clene Nanomedicine‘s remyelination therapy candidate, CNM-Au8, showed a “robust” ability to stimulate the production of new myelin and increase the number of myelin-wrapped nerve fibers in the brain and spinal cord of animals in models of demyelinating disease, allowing mice to recover motor skills, a study reports.
January 13, 2020 News by Marisa Wexler, MS First MS Patient Dosed in Phase 2 Trial of Potential Remyelinating Therapy CNM-Au8, Clene Announces The first participant has been dosed in the Phase 2 REPAIR-MS clinical trial examining the effects of CNM-Au8,Ā Clene Nanomedicine‘s investigational remyelinating therapy, on brain metabolism in people with multiple sclerosis (MS), the company announced. In MS, the immune system attacks myelin, the protective sheath that surrounds…
October 16, 2019 News by Alice MelĆ£o, MSc NMSS Awards $339K to Phase 2 Trial of Potential Remyelination Agent, Clene Nanomedicine Announces The National Multiple Sclerosis Society awarded more than $339,000 to Clene Nanomedicine to support clinical tests into its lead candidate CNM-Au8Ā in treatingĀ multiple sclerosis (MS) by protecting nerve cells and restoring myelin. The grant was awarded under the National MS Societyās Fast Forward program, which aims…
February 7, 2018 News by Iqra Mumal, MSc #ACTRIMS2018 – Clene Nanomedicine Presents Positive Results for MS Remyelinating Therapy Clene Nanomedicine says its pre-clinical studies demonstrate the remyelination effects of CNM-Au8, supporting its potential to treat multiple sclerosis (MS) and other demyelinating disorders. Clene presented its data in a session,Ā “Nanocrystalline Gold As a Novel Remyelination Therapeutic for Multiple Sclerosis,”Ā thatĀ took place at the third annual Americas…