People with multiple sclerosis (MS) have a significantly greater risk of developing dementia compared with the general population, according to a new systematic review and meta-analysis. Of nearly 38,000 MS patients assessed across 10 published studies, about 5% had a diagnosis of dementia. The prevalence was particularly high in…
increased risk
Obesity promotes molecular signatures associated with more inflammation and multiple sclerosis (MS) signaling pathways specifically in females, which may explain the link between obesity and a higher risk of MS in women. These are the findings of a new study analyzing data not only from obese and non-obese women…
Women with a history of depression around the time they get pregnant are at increased risk of developing autoimmune diseases such as multiple sclerosis (MS), according to recent research. Likewise, women who have an autoimmune disease are more likely to get depressed during pregnancy and in the year after…
Genetic variations in certain genes may increase the risk of developing progressive multifocal leukoencephalopathy (PML), a serious brain infection associated with certain treatments for multiple sclerosis (MS) and other conditions, a new study shows. The findings suggest that testing for four specific genetic variant could help to predict…
People with progressive forms of multiple sclerosis (MS) are nearly four times more likely to have serious infections — those leading to hospitalization — than those with relapsing-remitting MS (RRMS), according to a large study in Germany. This higher infection risk was found despite the fact that, during…
Fully vaccinated multiple sclerosis (MS) patients who are treated with Ocrevus (ocrelizumab) or Gilenya (fingolimod) have a significantly higher risk of COVID-19 infection than those given other immunosuppressive therapies, according to a study in Italy. Called breakthrough infections, these post-vaccination cases of SARS-CoV-2 — the virus that causes…
Maternal or paternal exposure prior to conception to the multiple sclerosis (MS) therapy Aubagio (teriflunomide) does not seem to increase the risk of adverse pregnancy events, including miscarriage, preterm birth, small newborn size, or malformations, according to the results of a recent Danish study. About…
The use of oral contraceptives does not increase the risk of a second attack of symptoms or the progression of disability in women with clinically isolated syndrome (CIS) or early stage multiple sclerosis, a study demonstrated. Notably, the researchers also “did not find a protective effect on disability…
Among people with nervous system damage indicative of multiple sclerosis (MS), but who don’t yet have the disease — a condition known as radiologically isolated syndrome or RIS — the risk of progressing to full-fledged MS is higher for those who are younger, have spinal cord lesions, and have…
Editor’s note: The Multiple Sclerosis News Today team is providing in-depth coverage of the virtual 37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Oct. 13–15. Go here to see the latest stories from the conference.
Experiencing serious infections during adolescence is tied to an increased risk of developing multiple sclerosis (MS) later in life, but those occurring in childhood don’t increase MS risk, according to a new Swedish study. The study also found that certain types of infections, especially those that affect the central…
The risk of invasive cancer may be slightly higher in multiple sclerosis (MS) patients treated with Gilenya (fingolimod) compared with those treated with rituximab, and with people from the general population, a Swedish study suggests. The study, “Cancer Risk for Fingolimod, Natalizumab, and Rituximab…
People with pediatric-onset multiple sclerosis (POMS) have a greater decline in cognitive function, and are more likely to experience cognitive impairment in adulthood, than those whose disease began when they were adults, a study reports. The study, “Long-term Cognitive Outcomes in Patients With Pediatric-Onset vs Adult-Onset…