research

The use of a computer-based program called BrainHQ led to significantly improved scores on cognitive tests among people with multiple sclerosis (MS), according to data from a small clinical trial in Nebraska. The study was led by Samantha Jack, PhD, as part of work she did as a…

Elevated blood levels of neurofilament light chain (NfL), an established biomarker of nerve damage, are associated with a higher risk of near-term disability worsening in people with multiple sclerosis (MS), according to a large study. Findings imply that there’s usually a window of time — about a year or…

A high level of adherence to disease-modifying therapies (DMTs) is associated with a significant, 25% lower risk of moderate or severe relapses in previously untreated people with multiple sclerosis (MS) compared with those failing to adhere to therapy, according to a study of real-world data in Italy. High…

Blocking the activity of a protein complex called the NLRP3 inflammasome lessened disease severity in a mouse model of multiple sclerosis (MS), a study reports. Results point to NLRP3 as a promising target to ease inflammation in people with MS, but additional studies will be needed to determine the…

Advanced Innovative Partners (AIP) has agreed to assist GlobeStar Therapeutics Corporation and SMI Healthcare in designing and running clinical trials to evaluate Project Amethyst, a patented triple combination of U.S.-approved medications aiming to prevent neurodegeneration due to multiple sclerosis (MS). This definitive agreement follows a…

An artificial intelligence (AI) program, called iQ-MS, outperforms traditional radiologist-based measures at quantifying changes in lesions over time in people with multiple sclerosis (MS), a new study shows. “iQ-MS is a sensitive and accurate tool for monitoring MRI scans in people with MS by providing quantitative metrics that value-add…

Chronic pain can make it harder for people with multiple sclerosis (MS) to be physically active, but some types of pain have a bigger effect than others, a study suggests. The findings show not just whether a patient is having chronic pain needs to be considered, but also what…

A stem cell transplant was found to be better than Lemtrada (alemtuzumab) for lowering disease activity and slowing disability worsening in people with highly active relapsing forms of multiple sclerosis (MS), a small study in Lithuania showed. While both treatments were similarly effective in the first couple of…

Targeting genes that control the daily activity cycle of cells that are responsible for repairing myelin in the brain and spinal cord may be a useful strategy for treating multiple sclerosis (MS), a new study shows. Findings also point to a potential link between myelin disorders such as MS…

People with multiple sclerosis (MS) of African descent had higher levels of inflammatory B-cells in the fluid around the brain and spinal cord compared with white MS patients in a small U.S. study. These findings may help to explain why Black people with MS tend to experience a faster…

More activity among certain immune cells, as well as differences in immune signaling molecules, iron regulation, and fat metabolism, may explain why multiple sclerosis (MS) progresses more over time in some people than in others, researchers report. These findings may help to better understand the molecular mechanisms leading to…

People with a higher genetic risk for multiple sclerosis (MS) were seen to have detectable differences in their gut bacteria in a small study. “There seems to be an association between genetic risk score and [changes in gut bacteria] in triggering the disease in a small cohort of MS…

Achieving NEDA — no evidence of disease activity — after two years of treatment was not common among people with relapsing-remitting multiple sclerosis (RRMS) at a center in Italy. NEDA more often was reached, however, when researchers didn’t include the first few months of treatment in their analysis, suggesting…

Experiencing certain stressors during childhood may predict the future presence and severity of fatigue, pain, and psychiatric conditions associated with multiple sclerosis (MS), according to a new U.S. study. Childhood physical and emotional stressors were each significantly linked to a higher likelihood of MS patients experiencing each of the…

Welcome to “MS News Notes,” a column where I comment on multiple sclerosis (MS) news stories that caught my eye last week. This week, the stories cover research presented at the joint meeting of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and the…

In a surprise discovery, researchers found that deleting a protein called integrin alpha-3 blocked harmful immune cells from accessing the brain — and prevented the onset of symptoms — in a mouse model of multiple sclerosis (MS). Now, the researchers say that targeting this protein might be one way…

Brain atrophy (shrinkage) in people with multiple sclerosis (MS) begins on average more than five years before disease symptoms appear, according to a new study based on machine learning models. “Although the onset of progressive brain tissue loss measured by MRI is not synonymous with the true biological…

Six months of treatment with foralumab, administered into the nose, led to decreases in microglial activity in five of six people with nonactive secondary progressive multiple sclerosis (SPMS) involved in an expanded access program. Microglia are resident immune cells in the brain believed to play a role in driving…

New research by scientists in Austria may shed light on the link between the Epstein-Barr virus (EBV) and multiple sclerosis (MS), and explain why only some people infected with EBV — previously found to raise the risk of MS by 32 times — go on to develop the neurodegenerative disorder. Distinct…

Treatment with the investigational therapy fenebrutinib significantly reduced the number of new inflammatory lesions visible on MRI scans in people with relapsing forms of multiple sclerosis (MS). Pharmacological data from the study suggest the anti-inflammatory experimental medication can get into the brain and spinal cord at levels high…

Five of six people with secondary progressive multiple sclerosis (SPMS) treated with an experimental oral therapy called OCH saw no disease activity over six months in a small clinical trial. That’s compared with 0% of the SPMS patients given a placebo, according to new data presented by Tomoko Okamoto,…

Infection with the Epstein-Barr virus (EBV) may prime the immune system to accidentally attack a brain protein called ANO2, new research shows. The findings may explain how EBV infection can lead to developing multiple sclerosis (MS), at least in some patients. Daniel Jons, PhD, a scientist at the…

Socioeconomic factors, specifically income and education levels, and marital status, were identified as risk factors for multiple sclerosis (MS) severity in a new study in Sweden. In fact, the study found that earning a higher income and having more years of education before being diagnosed with MS are associated with…

People with multiple sclerosis (MS) who switch between more than two disease-modifying therapies (DMTs) have a higher risk of relapses compared with those who never switch, regardless of how well these patients adhere to their prescribed medications, according to real-world study in Canada. These findings are consistent with…

Anxiety, depression, and other mental health issues are nearly twice as common in people with multiple sclerosis (MS) in the five years preceding disease onset than they are in the general public, a study reports. These findings add to growing evidence that people with MS often go through a…

People with multiple sclerosis (MS) in the United Kingdom are less likely to be on disease-modifying treatments (DMTs) compared with MS patients in other countries in Europe, a new study reports. “We know that getting early treatment with disease-modifying MS therapies can improve long term health and wellbeing.

The Accelerated Cure Project for Multiple Sclerosis and the Arab Board for Clinical Research have partnered with the Association of Diversity in Clinical Trials (AOD) to drive diversity and inclusion in clinical trials, including in those of multiple sclerosis (MS). The intent of the collaboration is to build…

Heligenics has discovered a number of variations in the interferon beta 1 (IFNB1) gene that may markedly improve the effectiveness of medications containing the interferon beta protein — a protein widely used in the treatment of multiple sclerosis (MS). The discovery was made using the biotechnology company’s…

The expression of a viral protein known as W-Env leads to the inflammatory activation of brain cells and impairs myelin repair in mouse models of multiple sclerosis (MS), a study reports. “Our study shows that the presence of W-Env in the brains of MS patients appears to generate a…

Among multiple sclerosis (MS) patients treated with Ocrevus (ocrelizumab), most of the disability worsening they experience is not associated with any relapse activity, according to an analysis of real-world data. “We present real-world data from our multiple sclerosis center underlining that in a typical population of relapsing MS…