research

The healthcare costs of secondary progressive multiple sclerosis (SPMS) are high, according to a real-world study in Spain, and higher still for younger patients and those with severe disability who cannot walk unaided, even for short distances. On average, yearly costs for one patient amount to more than €41,000…

An online training program for managing memory and cognitive difficulties may help people with multiple sclerosis (MS), a study suggests. The program, delivered entirely through virtual sessions, taught participants practical strategies to boost memory then guided them about using the techniques in real-world situations, such as organizing errands, planning…

Assessing multiple sclerosis (MS) disease activity using Octave Bioscience’s MS Disease Activity (MSDA) blood biomarker test can help guide clinicians’ decisions about care, a study showed. “Our goal is to empower both providers and patients with precision tools that transform MS care,” Doug Biehn, CEO of Octave, said…

Some exercises are better than others at easing certain problems associated with balance in people with multiple sclerosis (MS), and the most effective type may depend on a patient’s specific issue, a small study suggested. The findings “provide valuable insights into the long-term effects of these exercises,” the researchers…

Rituximab, sometimes used off-label as a multiple sclerosis (MS) treatment, may be as effective — at a much lower cost to patients — as the approved therapy Ocrevus (ocrelizumab) at managing relapsing forms of the disease, a new study from Egypt suggests. The study’s results showed that the…

People with multiple sclerosis (MS) who live in rural areas are 17% less likely to receive disease-modifying therapies (DMTs) than those in urban regions, a study involving people from the Canadian province of Alberta suggested. The likelihood was lower when considering therapies that are highly effective at controlling…

Biostate AI is partnering with the nonprofit Accelerated Cure Project (ACP) to develop a series of artificial intelligence (AI) models that can predict multiple sclerosis (MS) progression and how patients may respond to treatment. As part of the partnership, Biostate AI will use its high-throughput technology to…

Medicaid coverage for people with multiple sclerosis (MS) in the U.S. is associated with worse disease outcomes — including more clinical relapses and greater disability progression — compared with private insurance, according to a new study that investigated the impact of insurance type and socioeconomic factors on patient care. In…

Kyverna Therapeutics’ CAR T-cell therapy candidate KYV-101 was deemed safe and well tolerated, and showed preliminary signs of efficacy, in people with progressive forms of multiple sclerosis (MS) in clinical testing. That’s according to data from two investigator-initiated Phase 1 trials, which enrolled individuals with secondary progressive…

A pair of scientists have been awarded a 2025 Breakthrough Prize in Life Sciences for their work uncovering factors that give rise to multiple sclerosis (MS), paving the way for new therapeutic developments. Sometimes referred to as the “Oscars of Science,” Breakthrough Prizes are given each year to…

Clinical improvements in vision and cognition linked to the use of treatment candidate CNM-Au8 were correlated with signs of nerve cell repair and remyelination among people with relapsing-remitting multiple sclerosis (RRMS), according to new data. Remyelination is the process by which myelin, the fatty substance surrounding nerve cells…

A Phase 4 observational study called ENABLE is enrolling adults with relapsing forms of multiple sclerosis (MS) across the U.S. to better understand the safety, tolerability, and efficacy of Briumvi (ublituximab-xiiy) in the real world. At least 500 patients are expected to enter ENABLE (NCT06433752) at some…

A new artificial intelligence (AI) tool called MindGlide can accurately calculate, from a single MRI scan, multiple aspects of brain damage related to multiple sclerosis (MS) — even when employed with routine scans that are not typically used to monitor such damage. The development and validation of the tool…

People of Asian descent tend to be younger than white people when they first exhibit symptoms of multiple sclerosis (MS), a U.S. study reports. Asians also tended to be younger at the time of their diagnosis. No differences were found in demographics or disease characteristics between Asian patients…

Quantum Biopharma is partnering with researchers at Massachusetts General Hospital in Boston on a clinical study to test a positron emission tomography (PET) tracer for monitoring changes in myelin content in people with multiple sclerosis (MS).  The Phase 1 study (NCT04699747) is recruiting healthy adults and people…

Fibrobiologics’ investigational cell therapy CYMS101 can significantly increase myelin production and promote myelin repair in a mouse model of multiple sclerosis (MS), the company has announced. The experimental therapy, which is made of connective tissue cells called fibroblasts, demonstrated benefits within seven weeks after both single and multiple infusions…

People with multiple sclerosis (MS) may receive less frequent infusions of rituximab without increasing their chances of relapse or disease progression, according to a real-world study from Norway. After receiving three doses at six-month intervals, extending the time between following doses to nine months is “a safe and effective…

A small molecule that blocks the activity of a protein called TYK2 in the brain showed promise at reducing disease activity in mouse models of multiple sclerosis (MS), according to a study. The study was conducted by Neuron23, which is advancing a small molecule TYK2 inhibitor called NEU-627…

Sexual dysfunction affects 80% of women in Iran with multiple sclerosis (MS), with older age and lower education levels seen as key risk factors, a study found. The study, ”The prevalence of sexual dysfunction and its contributors among the women with multiple sclerosis,” was published in BMC Women’s…

A researcher and neurologist at Penn Medicine in Philadelphia has won the 2025 John Dystel Prize for Multiple Sclerosis Research for his work in uncovering immune mechanisms of multiple sclerosis (MS), identifying disease biomarkers, and finding new avenues toward tailored medicine. The prize comes with a sculpture and…

Nearly 50% of people with multiple sclerosis (MS) report pronounced fatigue, which has a significantly negative effect on their well-being, a new study from Finland has found. In an analysis of data from more than 500 patients from the Finnish MS registry, individuals with self-perceived fatigue were more likely…

Evidence of neurological damage over time — known as dissemination in time, or DIT — may not be necessary to reach a diagnosis of multiple sclerosis (MS) for all patients, according to a report by U.K. researchers. Traditionally, an MS diagnosis would typically require both DIT and DIS,…

Cognitive impairment is common in people with multiple sclerosis (MS) who have not previously received treatment, affecting about 1 in 4 patients, and rates are particularly higher in those with secondary progressive MS (SPMS), a new study found. “The current study demonstrates that a significant portion of MS…

Myrobalan Therapeutics has been awarded a grant of more than $850,000 from the National Multiple Sclerosis Society to advance its new oral candidate MRO-002 for treating progressive forms of multiple sclerosis (MS). The funding was made through the society’s Fast Forward program, which seeks to bridge the…

The law firm Kalfus & Nachman will host a special event to raise funds for multiple sclerosis (MS) research, patient care, advocacy, and increasing disease awareness. The fundraising will be held Friday, March 28, at 1:00 p.m., in the back parking lot of Kalfus & Nachman’s building, 870…

Antibodies that target proteins from the Epstein-Barr virus (EBV) also can inadvertently attack proteins in the brain, which may help to explain the link between EBV and multiple sclerosis (MS), a new study shows. Findings also indicate that antibodies targeting EBV as well as a person’s genetics both…

A group of manufactured chemicals called hydroxylated polychlorinated biphenyls, or OH-PCBs, which persist in the environment despite a ban on production, are associated with an increased risk of developing multiple sclerosis (MS), according to a new study. In turn, another family of compounds highly resistant to environmental breakdown, called…

In the lymph nodes of the neck of people with multiple sclerosis (MS), certain immune cells show abnormalities in activity and signs of reactions against the Epstein-Barr virus (EBV), a new study reports. The findings may help to explain the connection between MS and EBV, researchers said. The study,…

Neurons, also called nerve cells, collected from brain lesions of people with multiple sclerosis (MS) were found to accumulate new genetic mutations at a significantly faster rate than healthy neurons did, according to a new report. The researchers also found that neurons in such lesions exhibited distinct mutation…

Black people with multiple sclerosis (MS) walk more slowly and cover shorter distances over a certain time period than white people with the disease, a study in the U.S. finds. While the differences were somewhat attenuated when other factors that may impact walking ability were considered, such as age,…