Protamine, Anticoagulant Blocker, Seen to Aid Remyelination in Mice Within Limits

Protamine, Anticoagulant Blocker, Seen to Aid Remyelination in Mice Within Limits
0
(0)

Protamine — an agent used to stop the anticoagulant effects of heparin — was seen to trigger remyelination in mice with myelin damage. But while pointing a way forward for studies of myelin regeneration in multiple sclerosis (MS), the research team underscored that protamine itself is not an optimal treatment candidate.

The study, published in the journal PLOS One, reported that protamine acts to neutralize molecules that block processes involved in remyelination. Finding similar compounds with properties better suited to human use could lead to new regenerative therapies.

Having studied the processes that prevent myelin-forming cells from repairing damage, researchers at Tokushima Bunri University and Sokendai University in Japan screened for drugs that specifically blocked the activity of molecules called Chondroitin sulfate proteoglycans (CSPGs).

Patrícia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.
×
Patrícia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.
Latest Posts
  • My MS Manager app, Selma blair
  • scans and disability measures
  • Zeke, a MyoPro user
  • MMJ Bioscience study request

How useful was this post?

Click on a star to rate it!

Average rating 0 / 5. Vote count: 0

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?