News MS-specific Lineage of Oligodendrocytes May Provide New Hints on MS Development MS-specific Lineage of Oligodendrocytes May Provide New Hints on MS Development by Ana Pena PhD | November 15, 2018 Share this article: Share article via email Copy article link The cells that produce myelin in the brain and spinal cord, called oligodendrocytes, may play an active role in the onset or progression of multiple sclerosis (MS), according to a study combining data from MS mouse models and the human brain. This discovery supports the idea that in the context of MS, oligodendrocytes could act similarly to immune cells, a finding that may underpin new therapies targeted to these cells, rather than only to the immune system. The study, “Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis,” was published in the journal Nature Medicine. Oligodendrocytes are one of the most abundant cell types of the central nervous system (brain and spinal cord), and the ones responsible for producing the myelin sheaths that insulate nerve fibers and allow electrical impulses to be quickly transmitted. A team led by researchers at the Karolinska Institutet in Sweden have now found that oligodendrocytes, besides being producers of myelin, might be important players in the development of neurological diseases like MS. Researchers took an in-depth look at the profile of active and silenced genes in spinal cord oligodendrocytes of MS mouse models — namely the experimental autoimmune encephalomyelitis (EAE) model that mimics several aspects of MS. They analyzed the patterns of gene expression using a recent technique called single-cell RNA sequencing, which delivers a snapshot of the genetic activity of individual cells, providing scientists with clues about their properties and functions. Discuss the latest research in the MS News Today forums! Researchers saw that when MS-like disease was induced in mice, a group of oligodendrocytes and their precursor cells appeared, which had a unique pattern of gene expression. Specifically, they shared properties with cells belonging to the immune system. Importantly, these cells could behave like some immune cells that “ingest” other cells or molecules — a process called phagocytosis — and trigger an immune response against them, known as antigen presentation. These cellular processes take part in the destruction of myelin by the autoimmune response during MS. Similar to immune cells, the disease-associated oligodendrocyte lineage activated genes are involved in the stimulation of immune responses and immunoprotection. The oligodendrocyte progenitors could also regulate the survival and replication of T-cells, one of the most important immune cell types. Notably, and in line with the mice findings, the team also identified MS-specific oligodendrocytes in brain samples of MS patients. “Our study provides a new perspective on how multiple sclerosis might emerge and evolve,” Gonçalo Castelo-Branco, PhD, associate professor at the Karolinska Institutet and senior author of the study, said in a press release. “Current treatments mainly focus on inhibiting the immune system. But we can now show that the target cells of the immune system in the brain and spinal cord, oligodendrocytes, acquire new properties during disease and might have a higher impact on the disease than previously thought,” Castelo-Branco added. These findings suggest that oligodendrocytes may play unexpected roles and actively participate in the disease process as immunomodulators. “We will now continue with further studies to ascertain the part played by the oligodendrocytes and their progenitor cells in MS,” Castelo-Branco said. “Further knowledge can eventually lead the way to the development of new treatments for the disease.” Print This Page About the Author Ana Pena PhD Ana is a molecular biologist with a passion for communication and discovery. As a science writer, her goal is to provide readers, in particular patients and healthcare providers, with clear and quality information about the latest medical advances. Ana holds a Ph.D. in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in infectious diseases, epigenetics, and gene expression. Tags genes, immune system, myelin, oligodendrocytes
April 19, 2024 News by Lindsey Shapiro, PhD AAN 2024: Long-term data support early Kesimpta start in relapsing MS
April 18, 2024 Columns by Benjamin Hofmeister Learning how to write a ‘SOAP’ note feels different after an MS diagnosis
April 18, 2024 News by Marisa Wexler, MS AAN 2024: Sustained myelin, nerve cell gains with long-term CNM-Au8