31 Days of MS: Why You Should Get to Know NMO 31 Days of MS: Why You Should Get to Know NMO by BioNews Staff | March 5, 2021 Share this article: Share article via email Copy article link 31 Days of MS header Photo courtesy of Lelainia Lloyd Day 5 of 31 Lelainia Lloyd is a patient advocate in Canada. These are her words: March is Neuromyelitis Optica (NMO) awareness month. NMO is a rare disease that is often mistaken for MS. Many NMO patients are initially misdiagnosed with MS. For a long time, NMO was referred to as āSpinal-Optical MSā or āAsian MSā as this disease has a high prevalence in those of Asian descent. It also used to be referred to as āDevicās disease,ā after French neurologist EugĆØne Devic first described it in 1894. There are only about 1000ā3000 NMO patients as compared to 90,000 MS patients in Canada. While we often refer to MS patients as āzebras,ā NMO patients are referred to as āunicornsā because we are so rare. Unlike MS, there is a specific test to determine if a patient has NMO, called an NMO-IgG titer test which is a blood test that measures the level of Aquaporin 4 antibodies. A positive test is 100% accurate for NMO, but a negative test has a 30%ā40% chance of being a false negative. As a result, some patients with NMO have been misdiagnosed with MS. Once this false-negative result was discovered, the diagnostic criteria were revised. Patients no longer need a positive titer if they meet these other criteria.Ā NMO attacks happen swiftly and are more severe than MS attacks. An NMO attack can include inflammation of the optic nerve, which can cause permanent damage resulting in blindness, and inflammation of the spinal cord, which can cause loss of sensation, paralysis, loss of bowel and bladder control, and even death. Left untreated, NMO is fatal.Ā Up until recently, there were only three drugs used to treat NMO, all of which were for off-label use. Now we have three new therapies specifically for our disease. These therapies work to help prevent attacks. While MS patients are treated with immunomodulatory therapies, NMO patients are treated with immunosuppressants. If you have NMO and are misdiagnosed with MS, being on MS drugs will actually make you worse because they are not targeting the immune system in the right way. Getting the right diagnosis is a matter of life or death.Ā Multiple Sclerosis News Today’s 31 Days of MS campaign will publish one story per day for Multiple Sclerosis Awareness Month in March. Follow usĀ on Facebook and Instagram for more stories like this, using the hashtag #31DaysofMS, or go here to see the full series. Print This Page About the Author BioNews Staff BioNews, the owner and publisher of this site, employs science writers and editors, most of whom have PhDs in the life sciences, as well as veteran journalists, who ensure stories are well-written and easy to understand. Our stories undergo a comprehensive fact-checking and editing process to confirm accuracy, objectiveness, and thoroughness in order to best serve our audience of patients and caregivers.
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