MS lesions may start as small clumps of microglia in patient’s brain
In multiple sclerosis (MS), lesions in the brain may start with small clusters of immune cells called microglia, a…
Articles by Marisa Wexler, MS
Genetic model can help predict risk of MS in optic neuritis patients
A model based on genetic factors could help predict the risk of developing multiple sclerosis (MS) in people with…
ACTRIMS 2024: 2 treatments to aid remyelination near clinical trials
Convelo Therapeutics is developing two experimental oral treatments to promote myelin repair in multiple sclerosis (MS) and both…
ACTRIMS 2024: Evobrutinib fails to show superiority to Aubagio in Phase 3 trials
The experimental BTK inhibitor evobrutinib was no better than Aubagio (teriflunomide) at preventing relapses, reducing brain lesions, or…
ACTRIMS 2024: Progressive MS patients show gains in NG-01 OLE
Repeated treatment with the mesenchymal stem cell therapy NG-01 led to gains in mobility and cognition, along with patient-reported…
ACTRIMS 2024: Vidofludimus calcium lowers NfL levels in progressive MS
Treatment with Immunic Therapeutics‘ experimental oral therapy vidofludimus calcium (IMU-838) lowered the levels of a nerve damage marker…
ACTRIMS 2024: Most patients relapse-free after 6 years on Zeposia
About two-thirds of people with relapsing forms of multiple sclerosis (MS) remained completely free from relapses over six years…
ACTRIMS 2024: Molecule made by gut bacteria seen to ease MS in mice
Supplements of indole 3-lactate (ILA), a molecule made by gut bacteria, significantly reduced disease severity and promoted myelin repair in…
Association between proteins may predict early MS disease activity
An association between the proteins IgG1 and CXCL10 in the fluid around the brain may help predict the risk of…
Dark rim on MS lesions seen with standard MRI may mark activity
An imaging feature called the T1-dark rim, which is visible on standard MRI scans of people with multiple sclerosis…
Prioritize high-efficacy DMTs for children with MS, study suggests
Children with multiple sclerosis (MS) who start on high-efficacy therapies experience fewer relapses and reduced MRI disease activity in…
Treatment of progressive MS hits milestones in recent years: Review
Treatment options for progressive types of multiple sclerosis (MS) have expanded dramatically over the past decade, and several promising…
Online therapy platform found to boost mental health of patients
COMPASS, a digital tool that provides support for managing the daily challenges of living with a long-term health condition such…
Researchers call for more pragmatic clinical trials in MS
Few multiple sclerosis (MS) clinical trials have used a so-called pragmatic design, which evaluates the effectiveness of interventions in…
Computational model captures multiple sclerosis, genes to organism
An international team of scientists has created a computational model that seeks to give a picture of…
Immune cells in MS may enter brain via newly found ‘sewer system’
In neurological inflammatory conditions like multiple sclerosis (MS), inflammatory immune cells may enter the brain through arachnoid cuff exit…
Non-opioid compound has potential to ease chronic nerve pain
Scientists at The University of Texas at Austin (UT Austin) have developed a novel non-opioid compound, called FEM-1689, that is…
New MRI technique allows for more precise imaging of myelin sheath
Scientists have developed a technique to more precisely map the myelin sheath, the fatty covering around nerve fibers that…
Real-world data can be used to compare efficacy of MS treatments
Real-world data collected from a registry can be used to reliably compare the effectiveness of different multiple sclerosis (MS)…
University-educated MS patients are more likely to get DMT: Study
People with multiple sclerosis (MS) who received a university-level education are more likely to be on…
Myelin repair early in MS may protect against disability worsening
People in the early stages of multiple sclerosis (MS) who have more spontaneous myelin repair in the cortex —…
MS guidelines by Spanish society stress early, effective treatment
New guidelines from the Spanish Society of Neurology emphasize the importance of early diagnosis and prompt treatment in the management…
More disability, fewer resources in pregnant Black, Hispanic patients
In the U.S., pregnant people with multiple sclerosis (MS) who are Black or Hispanic tend to have…
2nd stem cell transplant may help stabilize MS disability: Small study
In people with multiple sclerosis (MS) who have previously received a stem cell transplant, a second transplant can…
Problems with workings of nuclear protein may drive nerve cell damage
Problems with the workings of a protein called hnRNP A1 drives nerve death in multiple sclerosis (MS) by affecting…
Ancient DNA reveal how MS risk genes arose, spread across Europe
Genetic changes that predispose people to developing multiple sclerosis (MS) first emerged among herding populations who migrated to Eastern…
MS patients have high levels of T-cells targeting EBV-infected B-cells
People with multiple sclerosis (MS) have high levels of T-cells in their spinal fluid that specifically target cells infected…
In MS, spinal cord atrophy, chronic inflammation predict progression
In people with multiple sclerosis (MS), disability worsening independent of relapse activity — commonly known as “silent progression” —…
Breastfeeding may reduce later MS risk for people with family history
In people with a family history of multiple sclerosis (MS), exclusive breastfeeding in the first months of life may…
MS activity not likely to be affected by dairy or gluten foods, study finds
An analysis of data covering nearly 200 people with multiple sclerosis (MS) found no association between dairy or gluten…