From Diagnosis to Finding the Right Treatment for Her: Sara’s Relapsing MS Story

Reasons to take a look at ZEPOSIA® (ozanimod) If you have relapsing MS, finding treatment that works best for you means knowing what treatment options are out there. Discover a once-daily pill for people living with relapsing MS: ZEPOSIA® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. It is not known if ZEPOSIA is safe and effective in children. Here are 5 things to know about ZEPOSIA. 1. ZEPOSIA is a once-daily pillUnlike many treatments for MS, ZEPOSIA is a pill that you take once a day. 2. ZEPOSIA was more effective than a leading injectable medicine (Avonex)*More than 1,700 people participated in the two clinical studies, combined. That's the largest number of people in two studies that compared one MS medication to another. *Avonex (interferon beta-1a). FEWER RELAPSESIn a one-year study, people who took ZEPOSIA had 48% fewer relapses than people who took a leading injectable medicine. And in a two-year study, people who took ZEPOSIA had 38% fewer relapses than with a leading injectable.&dagger; &dagger;In the one-year study, people taking ZEPOSIA had an Annualized Relapse Rate (ARR) of 0.181 vs 0.350 with a leading injectable. In the two-year study, people taking ZEPOSIA had an ARR of 0.172 vs 0.276 with a leading injectable. To measure relapses, the Annualized Relapse Rate was used, which is the average number of relapses a group of people have in one year. A total of 895 people were in the one-year study (ZEPOSIA 447, a leading injectable 448). A total of 874 people were in the two-year study (ZEPOSIA 433, a leading injectable 441). MORE PEOPLE WERE RELAPSE FREEIn the one-year study, 78% of people who took ZEPOSIA were relapse free at one year (versus 66% of people who took a leading injectable). And in the two-year study, 76% of people who took ZEPOSIA were relapse free at two years (versus 64% of people who took a leading injectable).&Dagger; &Dagger;A relapse was defined as new or worsening symptoms directly associated with MS that lasted more than twenty-four hours (after having a mostly stable neurological state for at least thirty days). FEWER NEW OR ENLARGING LESIONS (T2), TOOThe one-year study also showed that people taking ZEPOSIA had 48% fewer new or enlarging lesions (T2) than people who took a leading injectable medicine. And in the two-year study, people taking ZEPOSIA had 42% fewer new or enlarging lesions (T2) than with a leading injectable.§ §In the one-year study, people taking ZEPOSIA had an average of 1.47 lesions (T2) vs 2.84 with a leading injectable. In the two-year study, people taking ZEPOSIA had an average of 1.84 lesions (T2) vs 3.18 with a leading injectable. DISABILITY PROGRESSION WAS ALSO MEASUREDWhen taking ZEPOSIA or Avonex, 9 out of 10 people experienced no progression of physical disability. THERE WAS NO SIGNIFICANT DIFFERENCE in disability progression: 7.6% of people experienced disability progression with ZEPOSIA vs 7.8% with a leading injectable medicine. Physical disability progression was measured every 3 months and combined from both studies. 3. ZEPOSIA was also studied for safetyIt's important to know as much about your medicine as you can, including information about its safety. There were two studies—one lasting one year and another lasting two years. The studies looked at 882 people taking ZEPOSIA, and 90% of them stayed with the treatment for the entire clinical study. Of those who stopped taking ZEPOSIA, 3% did so because of a side effect they experienced. The rest left the studies for a variety of other reasons. Possible serious side effectsThese are the serious side effects reported by people who took ZEPOSIA during the clinical studies. Infections that can be life-threatening and cause death. Slow heart rate when you start taking ZEPOSIA. Liver problems. Increased blood pressure. Breathing problems, such as shortness of breath. Macular edema (a vision problem) Swelling and narrowing of blood vessels in your brain. Severe worsening of MS after stopping ZEPOSIA compared to before or during treatment. Allergic reactions. To learn more about these side effects and the possible symptoms, please see the Important Safety Information below. Most common side effectsDuring both of the clinical studies, people who took ZEPOSIA were asked to report any side effects that they experienced. These were the most common: Upper respiratory tract infections. Elevated liver enzymes. Low blood pressure upon standing. Painful and frequent urination. Back pain. High blood pressure. These are not all of the side effects of ZEPOSIA. Please see the Prescribing Information (link below) for information on all of the side effects reported by those taking ZEPOSIA. If you experience any side effects while taking ZEPOSIA, be sure to talk to your doctor right away. Please see the full Prescribing Information and Medication Guide for information on all of the side effects reported by those taking ZEPOSIA. 4. Doctors are encouraged by results with ZEPOSIA “Once-daily oral dosing has held great appeal to my patients, and I am pleased with the clinical results seen with ZEPOSIA.” — Edward J. Fox, MD, PhDDirector, Multiple Sclerosis Clinic of Central Texas || 5. The ZEPOSIA 360 Support™ program will help you every step of the wayZEPOSIA has a program to help guide you called ZEPOSIA 360 Support. You can talk to an MS Nurse Navigator about treatment with ZEPOSIA, navigating insurance benefits, assistance with financial support, and much more. You can call 1-833-ZEPOSIA (833-937-6742), Monday to Friday, 8 AM - 8 PM ET. Wondering if ZEPOSIA is right for you?Your MS healthcare team can tell you even more about ZEPOSIA. Schedule an appointment to ask about ZEPOSIA and whether it’s right for you. Here are some questions you can ask your MS healthcare team. And to learn even more about ZEPOSIA and the ZEPOSIA 360 Support program, visit ZEPOSIA.com || Paid medical consultant of BMS. INDICATION ZEPOSIA® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.It is not known if ZEPOSIA is safe and effective in children. IMPORTANT SAFETY INFORMATION Do not take ZEPOSIA if you: have had a heart attack, chest pain (unstable angina), stroke or mini-stroke (transient ischemic attack or TIA) or certain types of heart failure in the last six months. have or have had a history of certain types of an irregular or abnormal heartbeat (arrhythmia) that is not corrected by a pacemaker have untreated, severe breathing problems during your sleep (sleep apnea) take certain medicines called monoamine oxidase (MAO) inhibitors. Talk to your healthcare provider before taking ZEPOSIA if you have any of these conditions or do not know if you have any of these conditions. ZEPOSIA may cause serious side effects, including:Infections. ZEPOSIA can increase your risk of serious infections that can be life-threatening and cause death. ZEPOSIA lowers the number of white blood cells (lymphocytes) in your blood. This will usually go back to normal within 3 months of stopping treatment. Your healthcare provider may do a blood test of your white blood cells before you start taking ZEPOSIA. Call your healthcare provider right away if you have any of these symptoms of an infection during treatment with ZEPOSIA and for 3 months after your last dose of ZEPOSIA: fever. feeling very tired. flu-like symptoms. cough. painful and frequent urination (signs of a urinary tract infection) rash. headache with fever, neck stiffness, sensitivity to light, nausea, or confusion (symptoms of meningitis, an infection of the lining around your brain and spine) Your healthcare provider may delay starting or may stop your ZEPOSIA treatment if you have an infection. Slow heart rate (also known as bradyarrhythmia) when you start taking ZEPOSIA. ZEPOSIA may cause your heart rate to temporarily slow down, especially during the first 8 days. You will have a test to check the electrical activity of your heart called an electrocardiogram (ECG) before you take your first dose of ZEPOSIA. Call your healthcare provider if you experience the following symptoms of slow heart rate: dizziness. lightheadedness. feeling like your heart is beating slowly or skipping beats. shortness of breath. confusion. chest pain. tiredness. Follow directions from your healthcare provider when starting ZEPOSIA and when you miss a dose. Continue reading for additional possible serious side effects of ZEPOSIA. Before taking ZEPOSIA, tell your healthcare provider about all of your medical conditions, including if you: have a fever or infection, or are unable to fight infections due to a disease, or take or have taken medicines that lower your immune system. before you start ZEPOSIA, your healthcare provider may give you a chickenpox (varicella zoster virus) vaccine if you have not had one before. have had chickenpox or have received the vaccine for chickenpox. Your healthcare provider may do a blood test for the chickenpox virus. You may need to get the full course of the vaccine and wait 1 month before taking ZEPOSIA. have a slow heart rate. have an irregular or abnormal heartbeat (arrhythmia) have a history of stroke. have or have had heart problems, including a heart attack or chest pain. have high blood pressure. have liver problems. have breathing problems, including during your sleep. have eye problems, especially an inflammation of the eye called uveitis. have diabetes. are or plan to become pregnant or if you become pregnant within 3 months after you stop taking ZEPOSIA. ZEPOSIA may harm your unborn baby. If you are a female who can become pregnant, talk to your healthcare provider about what birth control method is right for you during your treatment with ZEPOSIA and for 3 months...

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From Diagnosis to Finding the Right Treatment for Her: Sara’s Relapsing MS Story

5 Things To Know About This Relapsing Multiple Sclerosis (MS) Treatment That Comes In A Pill (Sponsored)