The thyroid hormone thyroxine, or FT4, may play an indirect role in the development of multiple sclerosis (MS), which seems to be mediated by certain immune cells, a study suggests. “Future investigations should explore how these immune cells modulate MS onset and progression in the context of thyroid…
The Patient-Centered Outcomes Research Institute (PCORI) has awarded the Cleveland Clinic $6.7 million to identify optimal treatment strategies for people with relapsing-remitting multiple sclerosis (RRMS). The funds will support the extension study of the multicenter DELIVER-MS (NCT03535298) clinical trial. The study is comparing two MS treatment approaches…
The risk of multiple sclerosis (MS) is significantly higher in people who carry a variant of the HLA gene called HLA-E*01:01 and have a history of infectious mononucleosis (mono), the manifestation of an Epstein-Barr virus (EBV) infection, according to a study based on U.K. Biobank data. The higher…
One year of Tysabri (natalizumab) treatment improves working ability among people with relapsing-remitting multiple sclerosis (RRMS), according to new data from TITAN, an observational study by researchers in France that assessed the impact of the infusion therapy. Use of the approved therapy resulted in improvements across several parameters:…
A single 600 mg dose of Briumvi (ublituximab-xiiy) — instead of the approved 150 mg initial dose plus a 450 mg dose two weeks later — was well tolerated by adults with relapsing forms of multiple sclerosis (MS). That’s according to new data from the ENHANCE Phase…
From 2019 to 2023, people with relapsing-remitting multiple sclerosis (RRMS) in France on treatment with Tysabri (natalizumab) adopted more at-home dosing and longer periods between doses, according to a review by researchers of the French national hospital database. An increasing use of the therapy during…
Sacral neuromodulation (SNM), in which an implanted device delivers mild electrical pulses to the nerves that control the bladder, led to sustained improvements in urinary function in half of people with multiple sclerosis (MS) who underwent surgery to have the device put into place, according to a review of…
A group of manufactured chemicals called hydroxylated polychlorinated biphenyls, or OH-PCBs, which persist in the environment despite a ban on production, are associated with an increased risk of developing multiple sclerosis (MS), according to a new study. In turn, another family of compounds highly resistant to environmental breakdown, called…
A noninvasive brain stimulation technique called transcranial direct current stimulation (tDCS) doesn’t seem to ease fatigue in adults with multiple sclerosis (MS) when given at home with computer-based cognitive training, according to one of the largest studies of its kind. While the home-based intervention was deemed feasible, combining daily…
The Floodlight MS app, a digital health application used to track dexterity, walking function, and cognition in people with multiple sclerosis (MS), has been deemed cost-effective in a new analysis. Modeling simulations showed MS patients who use the app experience fewer relapses and slower disability progression, which would improve…
Nearly all adults with relapsing forms of multiple sclerosis (MS) said they are highly satisfied with the Sensoready autoinjector pen to self-administer Kesimpta (ofatumumab), according to a recent U.S. survey. High satisfaction was mainly driven by the reasonable administration time and ease of use, the researchers said. The…
Severe obesity during childhood and adolescence more than triples the risk of developing multiple sclerosis (MS), and losing weight through early lifestyle changes did not decrease the likelihood of MS, according to a nationwide study in Sweden. Although the overall risk remained low, with 0.13% of people…
Women with multiple sclerosis (MS) face a significantly higher risk of mental illness during and after pregnancy than those without the disease, according to a new study that analyzed data from more than 890,000 women in Canada. Mental health issues, mostly anxiety and depression, affected 42% of women…
Men with multiple sclerosis (MS) who started on high-efficacy disease-modifying therapies (DMTs) experienced significantly fewer relapses than those who started with moderate-efficacy DMTs, according to real-world claims analysis involving more than 10,000 U.S. patients. “No significant difference in relapse was found among females,” researchers wrote. “This observation highlights…
Exercise effectively reduces fatigue and improves muscular fitness in people with multiple sclerosis (MS), though the optimal exercise type and dose differ for each outcome, according to a meta-analysis of published studies involving more than 3,500 patients. Mind-body exercise, which combines physical movement, mental focus, and controlled breathing, was…
About four in five adults with stable multiple sclerosis (MS) for at least five years remained free of disease activity after stopping first-line treatment with a disease-modifying therapy (DMT), according to a study based on data from the DOT-MS clinical trial. Still, disease activity reemerged in roughly 20%…
Hospitalization for severe COVID-19 is significantly associated with a twofold higher risk of developing multiple sclerosis (MS), according to a study involving nearly the entire population of Sweden. No increased risk of MS was found among those who tested positive for SARS-CoV-2, the virus that causes COVID-19, or received…
Percutaneous tibial nerve stimulation (PTNS), a nonsurgical treatment that delivers mild electrical impulses to a nerve in the ankle, significantly reduced bladder activity and improved sexual function for women with relapsing-remitting multiple sclerosis (RRMS), according to a clinical trial. While PTNS is designed to modulate neural mechanisms involved in…
Higher blood levels of bile acids — molecules found in the digestive fluid bile, which helps absorb fat in the gut — are associated with a slower progression of multiple sclerosis (MS), as indicated by imaging scans, a study by U.S. researchers reported. In a small clinical trial in…
The rate of disability progression among people with relapsing-remitting multiple sclerosis (RRMS) has slowed over the years due to advances in disease-modifying therapies (DMTs), according to a long-term analysis. Patients diagnosed in recent decades have experienced fewer progression events associated with relapses, called relapse-associated worsening (RAW), and also…
Researchers at the Oregon Health & Science University have discovered a plant-derived small molecule that can promote the growth of cells that produce myelin, the protective coating around nerve fibers that’s damaged in multiple sclerosis (MS). The naturally occurring molecule, sulfuretin, blocks the activity of an enzyme that…
People with multiple sclerosis (MS) may have a slightly higher cancer risk than the general population, according to a recent study in France that reviewed a decade of data from more than 140,000 MS patients. The risk of bladder, brain, cervical, and kidney cancer was significantly increased in MS…
A sublingual formulation of cladribine, which is the active ingredient of the approved oral treatment Mavenclad, in relapsing multiple sclerosis (MS), showed comparable pharmacological properties to its name-brand counterpart. That’s according to preclinical data announced by BioNxt Solutions, the formulation’s developer, in a company press release.
An online education program called “Eating Well with MS” improved the dietary behavior of adults with multiple sclerosis (MS), and was deemed in a study to be practical to complete, interesting, and valuable for patients. “Our study completion rates highlight the practicality of the intervention,” the researchers evaluating the…
The National Multiple Sclerosis Society (NMSS) has updated its Pathways to Cures Roadmap to account for recent scientific advances in the search for a cure for multiple sclerosis (MS). The details were provided in the report, “The refined Pathways to Cures Research Roadmap for…
Glial cells, which mostly support the function of nerve cells, play key roles in multiple sclerosis (MS) disease progression and development, according to a stem cell-based study. “Most research and therapeutic strategies have so far focused on blocking the overactive immune system, but how cells in the brain itself,…
Kesimpta (ofatumumab) is more effective than Aubagio (teriflunomide) among people with multiple sclerosis (MS) from ethnically diverse groups, including Black and African American, Hispanic and Latino, and Asian individuals, according to an analysis of pooled clinical trial data. “Determining whether there are differences in how people respond…
Levels of the immune cell protein CHIT1 at diagnosis, taken from the spinal fluid via a spinal tap, may strongly predict how fast disability progression will occur in people with multiple sclerosis (MS), a new study suggests. Compared with standard clinical measures used to predict disease progression — such…
People with multiple sclerosis (MS) tend to experience a short-term reduction in disability and brain lesion volume after receiving stem cell therapy, according to a meta-analysis of nine studies detailing randomized clinical trials. After six and 12 months, however, the researchers found no differences in disability between patients…
People with multiple sclerosis (MS) have elevated immune responses to more proteins of the Epstein-Barr virus (EBV) than previously thought, according to a new study. EBV-specific immune T-cells isolated from MS patients could also respond to multiple proteins found in the brain, particularly those associated with myelin,…
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