Genetic susceptibility to multiple sclerosis (MS) depends on an individual’s particular combination of multiple risk variants, a study reveals. The study, “Genetic susceptibility to multiple sclerosis: interactions between conserved extended haplotypes of the MHC and other susceptibility regions,” was published in the journal BMC Medical…
A component of yeast cell walls — called MGCP — prevented disease in a mouse model of multiple sclerosis (MS) by activating anti-inflammatory immune T-cells while suppressing inflammatory T-cells, a study showed. This work also supporting the microbiome’s role in affecting inflammation in autoimmune diseases like MS. “We have…
A potential anti-inflammatory treatment, xB3-IL-1RA was able to reach the central nervous system of a rodent model of multiple sclerosis (MS), and with repeat doses delay disease onset and ease clinical symptoms, according to the investigational therapy’s developer Bioasis Technologies. These findings support the utility of Bioasis’ xB3 peptide…
Nvidia announced the launch of the U.K.’s most powerful supercomputer — called Cambridge-1 — which uses a combination of artificial intelligence (AI) and simulation to help scientists to better understand complex diseases such as multiple sclerosis (MS) and to design new therapeutics. Cambridge-1 is the first supercomputer designed…
High-potency therapies are more effective at reducing the frequency of symptom relapses in people with secondary progressive multiple sclerosis (SPMS) than low-potency medications, a 10-year study showed. Notably, there was no difference in the effectiveness of either high- or low-potency medicines to limit the progression of disability. “When the…
Using high-efficacy therapies as a first treatment for multiple sclerosis (MS) patients significantly increases the likelihood of having no evidence of disease activity after one and two years, compared to using moderately effective therapies, according to a real-world study of Norwegian patients. However, with each additional attempted treatment, the…
The enzyme TET1, which is progressively lost with age, is essential to activate genes needed to repair myelin — the sheath around nerve cells that is damaged in people with multiple sclerosis (MS) — a study in mice has found. The…
John and Catherine Seibyl, both alumni of Case Western Reserve University (CWRU) in Ohio, have pledged $7.5 million to the university to advance multidisciplinary research into multiple sclerosis (MS) and other neurodegenerative diseases. The funds will be shared strategically between CWRU’s School of Medicine and the Frances Payne Bolton…
Gilenya (fingolimod) at its approved 0.5 mg daily dose continues to be the optimal dose for people with relapsing-remitting MS (RRMS), a systematic review of 11 clinical trials confirmed. A 0.25 mg/day dose, however, also showed improvement over placebo in MRI outcomes and patient satisfaction, the researchers noted, and further…
Urinary problems, such as an urgency to urinate or a feeling of incomplete urination, are common among people with multiple sclerosis (MS), impacting more than half of patients, according to a large study in Italy. The researchers noted that urinary disorders…
Markedly low levels of a simple amino sugar called N-acetylglucosamine (GlcNAc) were found in the bloodstream of people with progressive forms of multiple sclerosis (MS) and correlated with greater disease severity and disability, a study reported. These findings support GlcNAc as…
Lower antibody levels in the bloodstream and younger age are associated with a greater likelihood of infection in people with multiple sclerosis (MS) receiving Ocrevus (ocrelizumab) therapy, a study has found. “Our work adds to the body of literature detailing real-world outcomes in MS patients treated with [Ocrevus] and…
The digital therapeutics company MedRhythms is launching a clinical trial to evaluate the safety and efficacy of MR-004, an experimental product that uses rhythmic sounds to improve walking abilities in people with multiple sclerosis (MS). The randomized…
LIF, a protein with anti-inflammatory and neuroprotective properties, can be successfully delivered to immune cells in the brain using a nanoparticle formulation, and partially reverses induced paralysis in a mouse model of multiple sclerosis (MS), a proof-of-concept study has found. These findings validate LIF-loaded nanoparticles as…
B-cell-depleting therapies given to adults with multiple sclerosis (MS) affect the production of antibodies targeting SARS-CoV-2, the virus that causes COVID-19, a study reported. This finding has “consequences” for immunity in this patient group, whether that immunity follows SARS-CoV-2 infection or…
The Autoimmune Registry (ARI) has opened a fundraiser, called “Cure the Mother’s Disease,” to support the development of a tool that might detect multiple sclerosis (MS) in early stages during an eye exam. This fundraiser, …
Certain fat molecules produced by gut microbes, which have protective immune-suppressing effects and may protect against multiple sclerosis (MS), are lower in women than in men, a case-control study has found. These findings may explain the greater MS susceptibility observed in women, the scientists…
A short film produced for Hispanic/Latinx people who live with multiple sclerosis (MS) improved patients’ understanding of the condition and the effectiveness of treatment, a study found. “Health communication interventions, like film, have been shown to be effective tools in promoting positive attitudes…
Treatment with Zeposia (ozanimod) significantly reduces the risk of relapse, decreases the proportion of patients experiencing a relapse, and has a better safety profile than Aubagio (teriflunomide) for people with relapsing multiple sclerosis (MS), according to an indirect comparison of clinical trial data.
Interim data from a Phase 2 trial of Immunic Therapeutics’ investigational oral therapy IMU-838 (vidofludimus calcium) in relapsing-remitting multiple sclerosis (RRMS) patients has established a once-daily, 30 mg dose as the most appropriate for future Phase 3 trials. The…
The 2021 John Dystel Prize for multiple sclerosis (MS) research has been awarded to Vijay Kuchroo, PhD, a professor at Harvard Medical School, in Boston, for his work in uncovering the underlying immune mechanisms that drive the neurodegenerative disorder. “Professor Kuchroo’s…
A 78-year-old man with multiple sclerosis (MS) developed the brain infection progressive multifocal leukoencephalopathy (PML) after two years of treatment with Ocrevus (ocrelizumab), a recent case report detailed. Treatment was discontinued and, as the patient’s symptoms worsened, he was moved to off-label…
A decline in the activity of the GPR17 gene is responsible for age-related brain deterioration caused by the loss of myelin, a fatty substance that surrounds nerve cells like a sheath, a mouse study discovered. Researchers identified a small molecule that rejuvenated…
A healthy diet led to better physical and mental quality of life in Dutch adults with multiple sclerosis (MS), especially women, a large survey study found. Substantial amounts of vegetables, fruits, fiber, and healthy fats were associated with better overall…
An antibody analysis has identified two biomarkers that can be used to predict the development of multiple sclerosis (MS) in people with optic neuritis, a study reports. Further research is, however, required to validate these findings…
An estrogen-based therapy, called indazole chloride (IndCl), was shown to protect against optic nerve damage in a mouse model of multiple sclerosis (MS), a study reported. IndCl may help to improve vision in people with the disease, but…
Scientists have discovered epigenetic changes in a gene called HTR2A, found only in immune cells isolated from people with secondary progressive multiple sclerosis (SPMS), a study reported. These findings suggest that such changes — external modifications to DNA that turn genes…
Long-term use of disease-modifying therapies (DMTs) in people with relapsing-remitting multiple sclerosis (RRMS) has a beneficial cumulative effect compared to shorter treatments, delaying the development of irreversible disability and conversion to secondary progressive MS (SPMS), a recent study…
Levels of myelin sheath components called ceramides are altered in the blood of people with multiple sclerosis (MS) and may be linked with retinal degeneration and physical disability, a study has found. Specific ceramides were altered only in those with progressive…
Exposure to stress before birth can worsen the clinical symptoms of multiple sclerosis (MS) during adulthood, a study in a mouse model of MS suggested. Investigators also found that prenatal stress can change the levels of a protein critical for neurological development, called…
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