Minipress (prazosin) for Bladder Dysfunction in Multiple Sclerosis

Bladder disturbances are common in people with multiple sclerosis (MS) and usually consist of urgency, frequency, incomplete emptying, and sometimes incontinence. After urinary tract infections are ruled out, a physician may prescribe a medication such as Minipress (prazosin).

Minipress belongs to the class of medicines called anti-hypertensives. It is used off-label in people with MS to help promote the flow of urine through the sphincter.

The therapy is a quinazoline derivative that causes a reduction in total peripheral resistance and directly relaxes vascular muscles, which may be related to a blockage of the adrenoceptors.

Minipress should be taken by mouth in 1 mg doses two or three times a day. The first time Minipress is taken by patients should be at bedtime.

There are side effects to Minipress, including fast or pounding heartbeats or fluttering in the chest; feeling like passing out; breathing problems; swelling in the hands, ankles or feet; and a painful penis erection for four hours or longer in men.

Other less serious side effects may include mild dizziness; weakness; tiredness; drowsiness; headache; or nausea.

There are generics available for Minipress.

Read the latest news about bladder dysfunction in multiple sclerosis.

Note: Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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