Clonazepam for multiple sclerosis
Fact-checked by What is clonazepam for MS?
Clonazepam is an oral medication approved in the U.S. to treat certain seizure disorders and panic disorder. It is sometimes used off-label to manage tremors, pain, and spasticity — involuntary muscle tightness, contractions, or spasms — in people with multiple sclerosis (MS).
These MS symptoms have been associated with abnormal nerve signaling in certain parts of the brain and spinal cord. Clonazepam, belonging to a class of medications called benzodiazepines, is thought to work by broadly calming down nervous system activity, which may help counteract abnormal signals involved in these symptoms.
In the U.S., clonazepam is available under the brand name Klonopin, which is licensed by Cheplapharm, and in several generic versions.
Therapy snapshot
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| Treatment name | Clonazepam |
| Usage | Used off-label to manage tremors, spasticity, and pain in MS |
| Administration | Oral tablets |
Who can take clonazepam?
Although not formally approved for treating MS, clonazepam may sometimes be used off-label to treat tremors, pain, or spasticity, particularly when other medications have not worked well enough.
According to the prescribing label for its approved indications, clonazepam is contraindicated for people with:
- a history of sensitivity to benzodiazepines
- signs of significant liver disease
- an eye condition called acute narrow-angle glaucoma
How is clonazepam administered?
Clonazepam is taken orally and is commercially available in the U.S. as tablets that are swallowed whole or allowed to disintegrate on the tongue.
There is no one specific dosing regimen for pain management in MS or for easing MS spasticity or tremors. Treatment is usually started at a low dose and gradually increased until the most effective and safe dose is identified. It may be taken three to four times daily.
Serious withdrawal symptoms are possible if the medication is stopped too quickly. For this reason, people who want to discontinue treatment should reduce their clonazepam dose gradually under medical guidance.
Clonazepam side effects
Common side effects associated with clonazepam include:
- drowsiness
- upper respiratory tract infections
- dizziness
- depression
- fatigue
- problems with walking and coordination
- memory and thinking difficulties
Clonazepam may increase the risk of suicidal thoughts or behavior. Patients using the medication should be carefully monitored for new or worsening changes in mood or behavior.
The medication comes with a boxed warning about the risks of abuse, misuse, and addiction, which can lead to overdose or death. Prolonged use may lead to physical dependence, and abruptly discontinuing the medication can cause serious withdrawal reactions.
Using clonazepam with certain other substances, including other benzodiazepines, opioids, and alcohol, can worsen side effects or be life-threatening. Patients should always tell their healthcare providers about any other prescription, over-the-counter, or recreational drugs they’re using.
Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
