Lioresal (baclofen) is a muscle relaxant used to treat muscle spasms caused by multiple sclerosis and spinal cord injuries. It has general central nervous system-depressant actions mainly at the spinal cord level and the upper motor neurons. Lioresal (baclofen) inhibits the transmission of synaptic reflexes.

Lioresal is taken by mouth in 5 mg doses three times a day. Dosage may be increased by daily 15 mg increments every three days up to a maximum dosage of 80 mg per day.

The most common side effects are confusion, dizziness or light-headedness, drowsiness, nausea, and muscle weakness. All common side effects may disappear once the body has adjusted to the treatment. After stopping the treatment, however, some serious side effects that may occur include convulsions, hallucinations, increase in muscle spasms, cramping or tightness, and emotional changes.

Generics available on the U.S. market for baclofen as an alternative to the brand-name Lioresal.

Note: Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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  1. https://online.epocrates.com/drugs/156/baclofen
  2. http://www.drugs.com/mtm/lioresal.html
  3. http://www.drugs.com/availability/generic-lioresal.html