Pomegranate Seed Oil May Be Therapy for MS Disease and Its Progression

Pomegranate Seed Oil May Be Therapy for MS Disease and Its Progression
5
(2)

In a recent study, researchers show how a natural antioxidant within pomegranate seeds is capable of inhibiting demyelination in a mouse model for multiple sclerosis (MS), supporting novel formulations of natural antioxidants as therapeutics for demyelinating diseases. The study, “Treatment of a multiple sclerosis animal model by a novel nano drop formulation of a natural antioxidant,” was published in the International Journal of Nanomedicine.

The team of researchers began by administering to mice — induced for experimental autoimmune encephalomyelitis (EAE), an established model for human MS — a nano droplet formulation of pomegranate seed oil (PSO) that they named Nano-PSO. In a previous study the team showed that Nano-PSO could significantly reduce brain lipids oxidation in a mouse model of prion disease (prion diseases, also known as transmissible spongiform encephalopathies, are a family of rare progressive neurodegenerative disorders). Although primarily considered an autoimmune disease, MS and EAE demyelination of nerve cells is also thought to occur as a result of a neurodegenerative process — most importantly, MS brain proteins and lipids are oxidized. In fact, oxidative stress is a common pathological feature of neurodegenerative diseases.

PSO contains what is thought to be one of the strongest natural antioxidants, a polyunsaturated fatty acid named punicic acid (PA). Administering PSO as an oil-in-water nanoemulsion is believed to increase both its bioavailability and activity.

Study results revealed that the administration of PSO with high levels of PA is beneficial for EAE mice. The oil, when delivered to mice in its natural form, was beneficial only at very high dosages; in contrast, when 1% of PSO was delivered as emulsified nano droplets, or Nano-PSO, the clinical benefits were significantly enhanced. The benefits were visible when Nano-PSO was given to mice at the time the disease was induced, and again when EAE mice start to develop disease symptoms (day 7). These results suggest that Nano-PSO has a therapeutic potential both for preventing the disease and for impairing its progression.

Moreover, the Nano-PSO inhibited demyelination and lipid oxidation in the brains of EAE mice that had already presented an established infiltration of immune cells, suggesting that oxidized lipids play a role in the demyelination process.

These findings further support the generation of natural antioxidants such as Nano-PSO as therapeutics for demyelinating diseases, including MS.

Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Laboratory of Doctor David A. Fidock, Department of Microbiology & Immunology, Columbia University, New York.
×
Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Laboratory of Doctor David A. Fidock, Department of Microbiology & Immunology, Columbia University, New York.
Latest Posts
  • Toxoplasma gondii
  • brain volume, RRMS
  • Extracellular vesicles

How useful was this post?

Click on a star to rate it!

Average rating 5 / 5. Vote count: 2

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?