Posts by: Patricia Inacio PhD

Patricia Inacio PhD

Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Laboratory of Doctor David A. Fidock, Department of Microbiology & Immunology, Columbia University, New York.

February 24, 2021February 24, 2021

Enrollment Complete in Phase 2 Trial Testing Temelimab

News

GeNeuro has completed patient enrollment in its ProTEct-MS Phase 2 clinical trial evaluating temelimab as a treatment for multiple sclerosis (MS), the company announced. The study (NCT04480307), taking place at ... Read more

February 11, 2021February 11, 2021

KIF5A Protein Levels in CSF May Act as Biomarker of Progressive MS

News

The levels of KIF5A protein are elevated in the cerebrospinal fluid (CSF) — the liquid surrounding the brain and spinal cord — of people with progressive multiple sclerosis (MS) ... Read more

January 11, 2021January 11, 2021

Cancer Therapy Seen to Protect Blood-brain Barrier, Ease MS in Mouse Model

News

Imatinib, a cancer treatment, stopped an injury response mechanism of the central nervous system (CNS) from activating, damage to which is a hallmark of multiple sclerosis (MS), an early ... Read more

January 6, 2021January 6, 2021

Less Sunlight Means More Risk of Relapse, Disability, Studies Assert

News

Reduced exposure to sunlight, previously reported as a risk factor for developing multiple sclerosis (MS), also seems to increase the risk for relapse and worsening disability, data from two ... Read more

January 4, 2021January 5, 2021

Boosting Cholesterol Recycling in Brain Facilitates Myelin Repair, Study Says

News

New research in mice suggests that poor recycling of cholesterol in the brain impairs the repair of myelin, the protective coat surrounding nerve cells that is lost in multiple ... Read more

December 17, 2020December 17, 2020

Restoring Neuregulin-1 beta 1 Protein Levels May Help Halt MS Progression

News

The levels of a protein called Neuregulin-1 beta 1 (Nrg-1beta1) decline with the onset and progression of multiple sclerosis (MS), a new study suggests. The findings support the potential ... Read more

December 10, 2020December 10, 2020

Children With MS Recover Better From Relapses Than Adults, Study Suggests

News

Despite having more severe first and second relapses, children with relapsing-remitting multiple sclerosis (RRMS) tend to recover better than adults with the disease, according to a study. Better recovery ... Read more

December 8, 2020December 8, 2020

Adolescents With MS Have Lower Levels of Physical Fitness, Study Reports

News

Adolescents with multiple sclerosis (MS) have lower levels of fitness compared with healthy teenagers of the same age and a sex, a study suggests. Findings also demonstrated that among ... Read more

November 30, 2020November 30, 2020

Fewer Pregnancies, Premature Menopause Linked to Early Onset of Progressive MS

News

Women who have never given birth are more likely to develop early onset of progressive multiple sclerosis, according to a new study, which also found that a woman’s number ... Read more

November 19, 2020November 19, 2020

Progressive MS Focus of EMSP Virtual Meeting Open to All Starting Today

News

Progressive multiple sclerosis (MS) is the focus of the 2020 virtual European Multiple Sclerosis Platform (EMSP) annual meeting that runs though Friday, Nov. 20. Registration is free for the two-day conference. Those ... Read more

November 16, 2020November 16, 2020

Infection With Toxoplasma Gondii Parasite May Protect Against MS, Study Suggests

News

Toxoplasmosis, an infection by the parasite Toxoplasma gondii, may confer a certain level of protection against multiple sclerosis (MS), according to the results of an Italian study. The study, ... Read more

November 9, 2020November 9, 2020

Monitoring Fluctuations in Brain Volume May Help Track RRMS Disease Progression

News

The brain volume of people with relapsing-remitting multiple sclerosis (RRMS) undergoes a dynamic cycle of enlargement and contractions, a new study shows. Patients with a lower volume (contractions) had ... Read more

November 6, 2020November 6, 2020

Small, Myelin-rich Vesicles May Help Control Immune Response in MS, Animal Study Shows

News

Extracellular vesicles (EVs), tiny sacs released from myelin-producing cells called oligodendrocytes, may help dampen the immune system’s attack against myelin, whose loss is the hallmark of multiple sclerosis (MS), ... Read more

October 6, 2020October 6, 2020

Pathway and Its Proteins Found to Control Myelin Repair, Renewal

News

A pathway controlled by three proteins — Daam2, Nedd4, and VHL — was identified by researchers as a key regulator of myelin production during central nervous system development and regeneration ... Read more

October 2, 2020October 2, 2020

MS Patients Should Avoid ‘Silver’ Tooth Fillings Due to Mercury, FDA Advises

News

People with multiple sclerosis (MS) are among the high-risk groups advised to avoid dental amalgams — silver-colored fillings that are 50% mercury — under new recommendations issued by the U.S. Food and Drug ... Read more

September 29, 2020September 29, 2020

Amarna Announces Research Collaboration for Testing MS Gene Therapy Platform

News

Dutch Amarna Therapeutics announced a research collaboration with Spanish Progreso y Salud Foundation (FPS) to investigate the efficacy of its gene therapy delivery technology in multiple sclerosis (MS) and diabetes. ... Read more

September 25, 2020September 25, 2020

MS Patients Have Higher Burden of Mental Disorders, French Study Finds

News

People with multiple sclerosis (MS) have a higher burden of mental disorders than healthy people or people with rheumatoid arthritis, a French population-based study suggests. The study, “Prevalence of ... Read more

September 3, 2020September 11, 2020

Targeting B-cells in Cerebrospinal Fluid May Lead to More Effective MS Therapies, Study Suggests

News

Immune B-cells are more abundant and have a pro-inflammatory profile in the cerebrospinal fluid (CSF), the fluid that bathes the central nervous system, compared to blood in people with relapsing-remitting ... Read more

August 25, 2020August 25, 2020

Children with MS May Have More Relapses, But They Recover More Fully

News

Children with multiple sclerosis (MS) recover more quickly and “significantly better” from relapses than do adults — patients with disease onset at age 18 or older, researchers reported. The study, ... Read more

August 25, 2020August 25, 2020

Mavenclad Effectively Lowers Relapse Rates, Study Comparing DMTs Finds

News

Mavenclad (cladribine) appears to be better at lowering relapse rates during the first two years of disease in relapsing-remitting multiple sclerosis (RRMS) patients than other MS therapies, including interferon, Copaxone ... Read more

August 24, 2020August 24, 2020

Genetic Variants May Explain High Levels of Antibodies Against Epstein-Barr Virus in MS, Study Suggests

News

Genetic variants may contribute to increased levels of antibodies against proteins of the Epstein-Barr virus — a known environmental risk factor for multiple sclerosis (MS) — in MS patients ... Read more

August 18, 2020August 19, 2020

Good Work Habits and Adjustments May Help Patients Keep Jobs

News

The degree to which people with multiple sclerosis (MS) are conscientious — a personality trait that reflects responsibility, organization, and goal-oriented skills — in their work habits can help to ... Read more

August 13, 2020August 14, 2020

Too Much Cortisol May Affect Attention of Cognitively Non-fatigue MS Patients

News

Multiple sclerosis (MS) patients have high levels of cortisol, a stress hormone, compared to healthy controls. Also, patients categorized as non-cognitive fatigue show a higher variability in cortisol levels and ... Read more

August 10, 2020August 10, 2020

1 in 5 MS Patients Don’t Adhere to Daily Oral DMTs, Real-world Study Finds

News

About 20%, or 1 in 5, multiple sclerosis (MS) patients fail to adhere to oral disease-modifying therapies (DMTs) taken each day, and about 1 in 4 stop using a prescribed ... Read more

August 5, 2020August 5, 2020

Coffee May Help Ease Fatigue in MS Patients With Milder Disability

News

Drinking coffee each day appears to help people with multiple sclerosis (MS) and milder disability and fatigue, with this patient group reporting in a questionnaire that caffeine allowed them to ... Read more

August 3, 2020August 5, 2020

Regular Exercise Helps Preserve Key Brain Areas, Study Finds

News

People with multiple sclerosis (MS) who exercise regularly are able to maintain volume in the hippocampus, a brain region responsible for learning and memory, a study reports. This work “adds ... Read more

July 31, 2020August 6, 2020

Mental Fatigue in MS May Be Due to Poorer Brain Response to Tasks

News

The debilitating mental fatigue that people with multiple sclerosis (MS) can feel after a cognitively demanding task may be due to less efficient use of the brain, a pilot study ... Read more

July 9, 2020July 10, 2020

Disability Builds in Relapsing MS in Ways Not Tied to Relapses, Analysis Finds

News

Disability appears to mostly accumulate in people with relapsing forms of multiple sclerosis (MS) in a progressive manner — rather than being due to relapses, a pooled analysis of ... Read more

July 8, 2020July 9, 2020

Switch from Tysabri to Ocrevus Seen as Safe, Effective in RRMS Patients in Small Study

News

Switching to Ocrevus (ocrelizumab) within a relatively short period is a safe and effective option for people with relapsing-remitting multiple sclerosis (RRMS) who stop treatment with Tysabri (natalizumab), a small and retrospective ... Read more

June 30, 2020July 7, 2020

Boosting Cellular Energy at Sites of Myelin Loss May Stop MS Progression

News

Loss of myelin in nerve cell fibers — the hallmark of multiple sclerosis (MS) — leads to a shortage of mitochondria, a cell’s powerhouse, denying these damaged fibers the energy ... Read more

June 22, 2020June 22, 2020

Hookworm Infection Seen to Boost T-cells That Regulate Immune System

News

A person infected through the skin by the hookworm Necator americanus shows a spike in regulatory T-cells, specialized immune T-cells that work to limit inflammation, and a controlled infection by ... Read more

June 16, 2020June 16, 2020

Aubagio Safely Used by 5 MS Patients With Active COVID-19 Infection

Covid-19, News

Five people with multiple sclerosis (MS) who tested positive for COVID-19 while being treated with Aubagio (teriflunomide) all developed a mild infection, had good outcomes, and experienced no disease relapses, a case ... Read more

June 5, 2020June 5, 2020

Ability to ‘Create’ Astrocytes Supports Their Damaging Role in MS, Like Diseases

News

An inflammatory environment can turn astrocytes, key supportive cells for neurons, into their killers, fostering the progression of neurodegenerative diseases like multiple sclerosis (MS), a new study shows. This ... Read more

June 4, 2020June 5, 2020

Gut Mucus May Help Ease MS, Other Neurological Diseases, Review Suggests

News

Tweaking the protective properties of the gut mucus, a layer lining the inside of the gut, to boost the proliferation of good bacteria potentially could halt the development of ... Read more

May 15, 2020May 15, 2020

Mindfulness Training Seen to Aid Cognitive, Emotional Well-being in Pilot Study

Covid-19, News

Four weeks of mindfulness meditation helped to improve thinking skills and a sense of emotional balance in people with multiple sclerosis (MS), and to a greater extent than cognitive ... Read more

May 8, 2020May 8, 2020

ZyVersa’s IC 100 Reduced Inflammation in MS Mouse Model, Study Finds

News

IC 100, a monoclonal antibody by ZyVersa Therapeutics that prevents the assembly of inflammasomes — a pro-inflammatory cellular complex — lessened inflammation and halted disease progression in multiple sclerosis (MS), a study ... Read more

May 8, 2020May 8, 2020

‘Transcient’ Damage to CNS Seen with Chemotherapy Used in Stem Cell Transplants for MS

News

A high-dose chemotherapy combination given to wipe out the immune system before its rescue with autologous hematopoietic stem cell transplant (aHSCT) can cause “transient” damage to neurons and supporting cells of ... Read more

April 30, 2020May 1, 2020

New Nanosensor May Help to Diagnose MS at Early Stages

News

April 17, 2020April 17, 2020

Study of Stem Cell Therapy for Highly Active RRMS Honored by CR Forum

News

The MIST Phase 2 clinical trial, supporting the potential of hematopoietic (blood cell-producing) stem cell transplant (HSCT) to significantly slow disability progression in highly active relapsing-remitting multiple sclerosis (RRMS) patients, has received a ... Read more

April 8, 2020April 8, 2020

Small Changes in Genes May Affect Myelin Production, Study Suggests

News

The small variants seen in the DNA code among individuals may affect the ability of oligodendrocytes to produce myelin, the protective coat surrounding neurons and whose destruction is a ... Read more