Posts by: Patricia Inacio, PhD

Patricia Inacio, PhD

Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Laboratory of Doctor David A. Fidock, Department of Microbiology & Immunology, Columbia University, New York.

September 20, 2018September 20, 2018

Lymphatic Vessels of Brain Carry Messages That Appear to Promote MS, Study Reports

News

Lymphatic vessels, the “roads” that work to clear waste material from the brain, can also carry messages that direct immune system attacks against myelin, promoting the ... Read more

September 19, 2018September 19, 2018

GeNeuro to Develop the MS Clinical Program of GNbAC1 Without Servier

News

GeNeuro announced it has reacquired from Servier the worldwide rights to commercialize and develop the investigational humanized antibody GNbAC1 for the treatment of multiple sclerosis (MS). The decision came ... Read more

September 17, 2018September 17, 2018

Gilenya More Effective Than Avonex in Lowering Relapse Rates, New Lesions in Children with Relapsing MS, Phase 3 Trial Shows

Alexa, News

Two years of treatment with oral Gilenya (fingolimod) significantly reduced the rate of relapses when compared to Avonex (interferon beta-1a) intramuscular injections in children and adolescents with relapsing forms ... Read more

September 5, 2018September 5, 2018

Higher Levels of Neurofilament Light Chain in Blood and Cerebrospinal Fluid Found in MS Patients, Supporting its Prognostic Potential

News

A meta-analysis of 13 case-control studies shows that the levels of the protein neurofilament light chain (NFL) are significantly higher in both the cerebrospinal fluid and ... Read more

August 31, 2018September 7, 2018

Cell-free Mitochondrial DNA in Cerebrospinal Fluid of Progressive MS Patients May Point to Neurodegeneration

News

Cerebrospinal fluid of progressive multiple sclerosis (MS) patients may carry lower levels of cell-free mitochondrial DNA, according to a team of researchers who say this may ... Read more

August 29, 2018September 4, 2018

Small Molecule TDP6 Activates Myelin Regeneration in Mice with MS, Other Diseases, Study Finds

News

A small synthetic molecule called TDP6 mimics a natural growth factor and promotes myelin regeneration in a mouse model of demyelination diseases such as multiple sclerosis (MS), ... Read more

August 24, 2018August 27, 2018

Cannabidiol Increases Inflammatory Suppressor Cells, New MS Mouse Study Shows

News

Non-psychoactive cannabidiol (CBD), one of the active compounds in medical cannabis, significantly reduced clinical signs of multiple sclerosis (MS)-like disease in an experimental autoimmune encephalomyelitis mouse model. Researchers ... Read more

August 22, 2018August 24, 2018

Myelocortical MS, New Disease Subtype Marked by Nerve Cell But Not Myelin Loss, Identified in Study

News

Researchers have identified a new subtype of multiple sclerosis (MS), one marked by nerve cell degeneration that occurs independently of immune system attacks against myelin, a ... Read more

August 21, 2018August 21, 2018

Deregulated RNA Molecules May Contribute to RRMS, Study Finds

News

The levels of three small, regulatory RNA molecules — long non-coding RNAs — are deregulated in blood samples of patients with relapsing-remitting multiple sclerosis (RRMS), a ... Read more

August 15, 2018August 17, 2018

Long-term DMT Use Seen to Lower Likelihood of RRMS Progressing to SPMS in Study

News

Long-term treatment with disease-modifying therapies (DMTs) appears to lessen the risk of disease worsening in relapsing-remitting multiple sclerosis (RRMS) patients, an 18-year follow-up study suggests. But these ... Read more

July 20, 2018July 20, 2018

Single Gene Variant May Identify MS Patients at Risk of Liver Damage Linked to Interferon-Beta Use, Study Says

News

A genetic variant close to a gene called interferon regulatory factor 6 (IRF6) may help to predict those multiple sclerosis (MS) patients most at risk of liver ... Read more

July 19, 2018July 23, 2018

Brain Iron Levels Correlate with MS Progression, Disability Risk, Study Shows

News

Evaluating the local differences in iron accumulation in the deep gray matter of the brain using a special magnetic resonance imaging (MRI) technique, may help identify multiple sclerosis ... Read more

July 16, 2018July 19, 2018

Nicotine and Beta-amyloid Work on Immune System in Ways That Ease MS Symptoms, Study Reports

News

Nicotine, the active agent in tobacco, and amyloid proteins, which underlie Alzheimer’s disease, bind to a receptor present in certain immune cells and work to lessen ... Read more

July 12, 2018July 12, 2018

Overreactive T-cells Can Transition into T-cells That Control the Immune Response, Study Shows

News

New research shows that overreactive and tissue-damaging T-cells can transition into regulatory T-cells that help to control the immune system’s response. These findings open the door ... Read more

July 2, 2018July 5, 2018

Winter Months Spent in Sunny Climes Can Lower MS Risk, Study Suggests

News

Greater exposure to sunlight during the winter months — part of a person’s lifetime exposure to ultraviolet radiation — can help to lower the risk of ... Read more

June 27, 2018June 29, 2018

After Ocrevus Approval, New Therapies May Become Available for MS, Report Suggests

News

Genentech‘s Ocrevus (ocrelizumab), approved in March 2017, has fueled a sea change in the treatment of multiple sclerosis (MS) patients in the U.S., leading to an increased interest in ... Read more

June 27, 2018June 27, 2018

New Fluorescent Imaging Tool Allows Researchers to Track Immune Cell Dynamics in MS Mouse Model

News

A new fluorescent imaging strategy allows researchers to track T-cells and further understand their dynamics in vivo, giving them insight into what happens when these immune ... Read more

June 25, 2018June 25, 2018

Online Aid for MS Patients with Cognitive Difficulties Now Part of MyMSTeam

News

MyHealthTeams together with Biogen launched a new online tool center, called MS and Cognition Resource Center, to educate multiple sclerosis (MS) patients on brain health, and ... Read more

June 22, 2018June 22, 2018

#EAN2018 – Mavenclad Greatly Reduces Risk of RRMS Relapse, Analysis Finds

News

New retrospective analysis of the Phase 3 CLARITY study (NCT00213135) shows that treatment with Mavenclad (cladribine tablets) improved annualized relapse rate and magnetic resonance imaging (MRI) outcomes in ... Read more

June 21, 2018June 26, 2018

#EAN2018 – Both Brain and Spinal MRIs Needed to Monitor MS Inflammation, Study Says

News

Magnetic resonance imaging (MRI) used to assess inflammation in multiple sclerosis (MS) patients should include scans of the spinal cord and not be restricted to the ... Read more

June 20, 2018June 20, 2018

#EAN2018 – Levels of Neurofilament Light Chain Can Predict Disease Progression in RRMS, Study Shows

News

Levels of neurofilament light chain are a reliable predictor of disease worsening and progression in relapsing-remitting MS (RRMS) patients, a new study shows. Moreover, treatment with Gilenya (fingolimod), marketed ... Read more

June 19, 2018June 19, 2018

Atara Biotherapeutics Study Links Epstein-Barr Virus Infection with MS

News

Analysis of post-mortem brain samples from multiple sclerosis (MS) patients and healthy individuals (without neurologic disease) showed that while signs of Epstein-Barr virus (EBV) infection are ... Read more

June 15, 2018June 15, 2018

Discovery of ‘Fiery’ Cell Death Mechanism May Be MS ‘Game-Changer’

News

Researchers have unveiled a new cell death mechanism called pyroptosis — also known as “fiery death” — as a main factor driving neurodegeneration and loss of myelin ... Read more

June 6, 2018June 6, 2018

#CMSC2018 — Inhibiting Oxidative Stress Enzyme Promotes Resealing of Blood-Brain Barrier in MS Mouse Model

News

Inhibiting an oxidative stress enzyme called myeloperoxidase protects the blood-brain barrier in a mouse model of multiple sclerosis (MS), limiting the migration of immune cells and ... Read more

June 6, 2018June 6, 2018

#CMSC2018 – Gains in Functional Abilities Seen in Lemtrada-treated MS Patients Over Six Years, CARE-MS II Extension Study Shows

News

Patients with active relapsing-remitting multiple sclerosis (MS) continue to show improvement — lesser functional disability across a variety of measures — and often without the need ... Read more

June 5, 2018June 7, 2018

#CMSC2018 – New Phase 2 Data Supports Ublituximab in Effectively Lowering Relapses, Depleting B-cells in MS Patients

News

New results from a Phase 2 trial evaluating TG Therapeutics’ ublituximab continue to support the therapy’s efficacy in treating relapsing forms of multiple sclerosis (MS). This ... Read more

June 5, 2018June 5, 2018

Oryzon Genomics Readies Updates on ORY-2001, Being Tested in MS Patients in Phase 2 Trial

News

Oryzon Genomics will give updates on its leading investigational product ORY-2001, a brain-targeting epigenetic therapy now in a Phase 2 clinical trial recruiting multiple sclerosis patients, ... Read more

May 21, 2018May 24, 2018

Gut Microbiome May Offer Way to Ease or Halt Brain Inflammation, Study Suggests

News

Metabolites produced by microbes in the gut can ease inflammation in the central nervous system by limiting the damage done by microglia, an immune cell of the ... Read more

May 17, 2018May 17, 2018

Viral Infection Promotes Factor in T-cells Leading to Brain Tissue Destruction

News

Infection with lymphocytic choriomeningitis virus triggers expression of a factor called TOX in immune cells strengthening their migration into the brain and promoting damaging effects, including ... Read more

May 14, 2018May 14, 2018

Biomarker in Cerebrospinal Fluid Seen to Predict MS Progression in Study

News

A potential biomarker — the ratio of antibody proteins in cerebrospinal fluid at the time of diagnosis — was seen to predict which  multiple sclerosis patients will ... Read more

May 8, 2018May 8, 2018

New Class of Anti-inflammatory Compounds May Help Halt Inflammation in MS, Study Suggests

News

A new class of indoline derivatives shows potent antioxidant and anti-inflammatory activities capable of decreasing inflammation in the brain, new research shows. This finding highlights the potential of ... Read more

May 1, 2018May 21, 2018

#AAN2018 — Ocrevus Lowers Immune Response to Vaccines in Relapsing MS, Phase 3 Trial Shows

News, Ocrevus

Treatment with Ocrevus (ocrelizumab) is linked to a reduced immune response to vaccinations in patients with relapsing multiple sclerosis (MS), according to a Phase 3 trial. These results were recently ... Read more

April 27, 2018April 27, 2018

#AAN2018 – Extending Time Between Tysabri Doses Linked to Lower PML Risk, Analysis Suggests

News

Extending the time between standard doses of Tysabri (natalizumab) from four weeks to up to 12 weeks is linked to a significant decrease in the risk of progressive multifocal ... Read more

April 26, 2018May 1, 2018

#AAN2018 – Cladribine Injections Deplete Number of Memory B-cells in RRMS, Study Shows

Lemtrada, News

Cladribine treatment leads to a selective depletion of memory B-cells in patients with relapsing-remitting multiple sclerosis (RRMS), researchers report. The results are in the presentation “Cladribine for the Effective ... Read more

April 25, 2018

#AAN2018 — ALKS 8700 Shows Promise as RRMS Therapy, Phase 3 Trial Interim Results Suggest

News

A one-year analysis of the ongoing Phase 3 EVOLVE-MS-1 trial of ALKS 8700 as a therapy for relapsing remitting multiple sclerosis (RRMS) supports the experimental therapy’s effectiveness, ... Read more

April 24, 2018April 24, 2018

#AAN2018 – High Fish Consumption Linked to Lower MS Risk

News

A diet rich in fish consumption and supplemented with omega-3 polyunsaturated fatty acids (PUFAs) is linked to a reduction of 45 percent in the risk of developing ... Read more

April 23, 2018April 30, 2018

#AAN2018 – Blood Stem Cell Transplant Superior to DMDs in Highly Active RRMS, MIST Trial Shows

News

Autologous non-myeloablative hematopoietic stem cell transplant was found to be significantly better at reducing risks for disability in relapsing-remitting multiple sclerosis patients compared to disease-modifying drug ... Read more

April 20, 2018May 21, 2018

#AAN2018 – Switching from Rebif to Ocrevus Improves MS, Extension Study Shows

News, Ocrevus

Continuous treatment with Ocrevus (ocrelizumab) or switching from Rebif (interferon beta-1a) to Ocrevus leads to a significant long-term reduction in relapsing multiple sclerosis activity, a two-year extension study ... Read more

April 19, 2018April 19, 2018

#AAN2018 – Biogen Data Covers Work into an MS Blood Biomarker, Cognition and Life Quality

News

Research that points to a potential blood biomarker of multiple sclerosis (MS) severity, relates cognitive difficulties to patients’ employment and other measures of socioeconomic status, and one-year results ... Read more

April 19, 2018April 19, 2018

#AAN2018 — Investigational Therapy Ibudilast Slows Brain Atrophy in Phase 2 Trial for Progressive MS

News

Investigational therapy ibudilast leads to a significant reduction of brain atrophy, supporting its potential to effectively treat progressive multiple sclerosis (MS), new data from a Phase 2 clinical ... Read more