First Multiple Sclerosis Blood Biomarker Discovered; Test May Soon Be Available

First Multiple Sclerosis Blood Biomarker Discovered; Test May Soon Be Available

Scientists have discovered the first blood biomarker for multiple sclerosis (MS) –  a chemical identifier in the blood.

The discovery should lead to a simple blood test that makes it quicker and easier to follow the course of MS, a debilitating disease of the central nervous system affecting around 2.3 million people globally.

Macquarie University researchers in Australia led the 12-year international effort that identified the biomarker, which will allow clinicians to determine which of the three types of MS a patient has with 85-90 percent accuracy.

The research,“Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression,” was published in the journal Nature Scientific Reports.

“This is a significant discovery because it will facilitate the ability to quickly and simply make a prognosis of the three types of MS and will allow clinicians to adapt their treatment for MS patients more accurately and rapidly,” Professor Gilles Guillemin, who oversaw the study, said in a news release.

The findings may also further scientists’ knowledge of other inflammatory and neurodegenerative diseases, such as Alzheimer’s, Parkinson’s and Amyotrophic Lateral Sclerosis (ALS).

“The [blood] test itself relies on detecting compounds within a specific biochemical pathway that uses a chemical called tryptophan,” Guillemin said. “Tryptophan is known to be involved in brain inflammation, and so by increasing our understanding of how our cells process tryptophan, we will be better able to identify its involvement in many types of neurodegenerative diseases.”

Researchers found that abnormalities in the kynurenine pathway (KP) of tryptophan are associated with a switch from the early-to-mild stage of MS to debilitating progressive forms. They also  realized that an analysis of KP metabolites in the serum of MS patients might be used as a disease biomarker.

“With the support of Dianti MS Pty. Ltd., an Australian company, we are currently developing a new prognostic kit with Dr Alban Bessede at ImmuSmol, France, which will help the medical profession and laboratories around the world quickly and easily identify the type of MS the patients has.” Guillemin said.

A blood test kit could be available in as little as two years, researchers said. The study’s findings could open new avenues for the development of MS therapies, and provide patients with personalized treatments.

“The unique information that we will receive from the biomarker within an individual means that it could also be possible to develop biomarker-guided personalised treatment for each patient,” said Edward Lim, lead researcher at Macquarie University, and a former MS Research Australia Postdoctoral Research Fellow at the University of South Wales in Sydney.

“MS Research Australia has been an enthusiastic supporter of this research right from its inception. We have been excited to be part of the translation of this initially fundamental research into a potential clinical test. This has the clear capacity to be the first ever blood biomarker for the prognosis of MS, and in doing so will meet one of the real unmet needs in the clinical management of MS,” said Matthew Miles, CEO of MS Research Australia.

 

Patrícia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.
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Patrícia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.
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5 comments

  1. Keiko Palmero says:

    I would greatly appreciate further updates on biomarker and diagnosis of MS, I was just recently diagnosed after months of testing. Now suffering our medical system to afford the medication I need!

    Thank you for all your hard work on this debilitating disease! You need to know as patients we are constantly looking for new information and it’s because of all of you we have hope!
    Keiko Palmero
    USA

  2. Rhonda Faithfull says:

    I have had MS for more than half of my life. My plan is to take it day by day. I am now in remission, for which I am gratefull. I now want to continue my tertiary education an complete my master of communication next year.

  3. LindaL Halvorson says:

    This is great news. It typically took 3 years from onset to diagnosis back in the 1970’s and even then they still weren’t sure. Onset destroyed my college education in music as symptoms would come and go based on the amount of rest especially during breaks in schedule. By the time my symptoms put me in the hospital looking for a brain tumor, I was greatly relieved to be sick physically and not just imagining things!

  4. Jessica Wilson says:

    I would love to know for sure what type of MS I have. I was told I have RRMS but feel that I have SPMS being the I have symptoms that never go away and get worst. To know would be great.

  5. Amanda says:

    I’m STILL trying to get a diagnosis after almost 7 YEARS!! I’ve had over TWENTY doctors each say something to the effect of “gee… This looks a lot like MS…”, but none of them will put the diagnosis in my file, because it’s a “diagnosis of exclusion” and they’ve already ‘diagnosed’ me with over FIFTY diagnoses! Most of these ‘diagnoses’ are actually just the SYMPTOMS that either I described to them or that they clinically observed! It’s ridiculous! So many of these ‘diagnoses’ are actually SYMPTOMS OF MS that it is just disheartening… I mean if I go to a doctor and they are allowed to say to me, “So, because of the MS, you can’t walk. When were you last able to walk using a walker/cane without the assistance of another person?”, then why can they not DIAGNOSE me with MS and actually TREAT me for it?!

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