Vaccines are not a risk factor for multiple sclerosis (MS), a large data analysis spanning more than 12,250 MS patients in Germany shows.
Fewer vaccinations were given to people who — five years later — would be diagnosed with MS, compared to those who would be diagnosed with other autoimmune disorders or not develop any such disease, it found. Whether vaccines could be protective against MS onset is yet to be determined.
The study “A large case-control study on vaccination as risk factor for multiple sclerosis” was published in the journal Neurology.
As the root cause of MS is not fully understood, and disease mechanisms are said to be immune-mediated, cases where MS was found in a person recently vaccinated raised questions of a possible relationship between the two.
Vaccine safety in people with MS is of great importance. Vaccines are able to prevent some infections known to accelerate MS progression, and to increase the risk of relapses. Except for the yellow fever vaccine, studies have generally found that vaccines are safe, and do not increase the risk of MS onset or relapses.
To collect further evidence on vaccine safety and MS, a team of researchers at the Technical University of Munich (TUM) used a large, nationwide claims database covering more than 200,000 individuals, including 12,262 MS patients.
The researchers found that five years before being diagnosed with MS, these patients went without a number of vaccinations, compared to two groups of people with other chronic autoimmune diseases — Crohn’s, an inflammatory bowel disorder (IBD), and psoriasis, a chronic skin disease — and healthy individuals, all of whom served as controls.
These results were true for all the vaccines investigated: those against pneumococci, meningococci, mumps, measles, rubella, chickenpox, human papilloma virus (HPV), hepatitis A and B, tick-borne encephalitis (TBE), and influenza.
We are sorry that this post was not useful for you!
Let us improve this post!
Tell us how we can improve this post?