According to BrainStorm Cell Therapeutics, these data will help in determining the benefits of NurOwn, the company’s stem cell-based therapy, in progressive MS patients participating in its ongoing Phase 2 trial (NCT03799718). This trial is enrolling up to 20 eligible adults at sites in the U.S.; information is available here.
Findings from this new study — called SysteMS — are in a poster to be presented at the MSVirtual2020 meeting, a joint Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) and European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) online conference set for Sept. 11–13.
“In this analysis, we have demonstrated a correlation between specific brain and spinal cord MRI measures and observed functional improvements in progressive MS patients,” Tanuja Chitnis, MD, a professor of neurology at Harvard Medical School, senior neurologist at Brigham and Women’s Hospital, and director of the Comprehensive Longitudinal Investigations in MS at the Brigham (CLIMB Study), said in a press release.
“We are grateful to the joint ACTRIMS/ECTRIMS abstract committee for allowing us to present these data,” Chitnis added.
SysteMS is part of CLIMB, a large and long-term study designed to specifically investigate the course of MS in the context of today’s treatments and technologies.
In this sub-study, Chitnis and colleagues analyzed MRI data on 48 people with primary progressive MS (PPMS) or non-active secondary progressive MS (SPMS), who met the inclusion criteria of those participating in the NurOwn trial.
These patients underwent a series of analyses designed to assess multiple MRI measures, including brain and lesion volumetric analysis, and mean upper cervical cord (MUCCA) analysis within one or two years of their baseline MRI scan, that taken when they first entered the CLIMB study. (MUCCA analysis helps to assess the severity of spinal cord atrophy, or shrinkage, in a person.)
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