Tecfidera (dimethyl fumarate) may be an effective treatment option for patients with early relapsing forms of multiple sclerosis (MS) who fail to respond adequately to glatiramer acetate, according to a post-hoc analysis of an observational study.
The findings were reported in an article, “Effectiveness of Dimethyl Fumarate in Patients With Relapsing Multiple Sclerosis Switching After Suboptimal Response to Glatiramer Acetate, Including Patients With Early Multiple Sclerosis: Subgroup Analysis of RESPOND,” published in the journal Neurology and Therapy.
Marketed by Biogen, Tecfidera is an oral disease-modifying therapy (DMT) that has been approved as a first-line treatment for adults with relapsing-remitting MS (RRMS) in several countries worldwide. In the U.S., the therapy is approved for the treatment of relapsing forms of the disease, and several generics have also been approved, including those marketed by Cipla, Lupin, and Mylan.
The therapy is thought to lower inflammation and oxidative stress — cell damage caused by high levels of oxygen reactive species — in the brain and spinal cord by interfering with a signaling cascade involving Nrf2, a protein that controls the activity of genes that regulate oxidative stress.
In previous clinical trials, Tecfidera was found to be superior to a placebo at lowering MS relapse rates and increasing the time to disease worsening. A comparative study and a systematic review have also found Tecfidera to be more effective than other injectable DMTs, including glatiramer acetate (sold as Copaxone, among others) at reducing annual MS relapse rates and delaying the time to first relapse.
Now, investigators at Biogen and collaborators reported the findings of a post-hoc analysis of RESPOND (NCT01903291), a 12-month observational study that aimed to evaluate the effectiveness of Tecfidera — when given in 240 mg capsules twice daily — to adults with relapsing MS who failed to respond adequately to glatiramer acetate treatment.
Previous data from RESPOND showed that in the overall population of patients participating in the trial, the annual MS relapse rate dropped by 78% in the year after they started Tecfidera treatment compared with the year before treatment initiation.
Additionally, treatment with Tecfidera improved several patient-reported outcomes, including overall physical and mental health, over the course of the study.
We are sorry that this post was not useful for you!
Let us improve this post!
Tell us how we can improve this post?