treatment

The University of California (UC) San Diego School of Medicine and Chiba University School of Medicine, Japan, are working together to establish a new center for immunology research, with a particular focus on the microbiome and mucosal immune responses that are known to play a crucial role in a variety of diseases, including multiple sclerosis (MS). “This…

A case report of a woman with relapsing-remitting multiple sclerosis (MS), who developed progressive multifocal leukoencephalopathy (PML) after natalizumab therapy, found that the immune-boosting molecule interleukin-2 (IL-2) might be a viable therapeutic option to fight this life-threatening complication although further study is needed. The case report, “Use of interleukin-2 for…

A commonly prescribed multiple sclerosis (MS) medication may act to modulate the immune system. The finding is described in the article “Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2,“ published in  the journal Proceedings of the National Academy of Sciences. MS develops due to an…

The United Spinal Association, a nonprofit focused on improving the quality of life for people with spinal cord injuries and disorders (SCI/D), a group of conditions that include multiple sclerosis (MS), announced it will have an exhibit booth at the Consortium of Multiple Sclerosis Centers‘ (CMSC) 30th Annual Meeting, to be held at the…

A substance called fluorosamine was seen to boost remyelination in mice by preventing the synthesis of chondroitin sulfate proteoglycans and by promoting oligodendrocyte function. The findings showed that targeting molecules that block remyelination may be a promising therapeutic approach in multiple sclerosis (MS). Upregulation of chondroitin sulfate proteoglycans — large molecules…

TG Therapeutics recently announced the opening of a new clinical trial evaluating TG-1101, its glycoengineered anti-CD20 monoclonal antibody, in patients with relapsing-remitting multiple sclerosis (RRMS). The Phase 2 clinical trial, titled “A Placebo-Controlled Multi-Center Phase 2 Dose Finding Study of Ublituximab, a Third-Generation Anti-CD20 Monoclonal Antibody, in Patients…

Clinical results presented at the recent Academy of Managed Care Pharmacy (AMCP)‘s 2016 annual meeting in San Francisco showed that the use of H.P. Acthar Gel during multiple sclerosis (MS) relapses is associated with beneficial outcomes. The gel, according to its producer, is also available at a lower price than other frequently used…

The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recently recommended marketing authorization to Zinbryta (daclizumab) for the treatment of patients with relapsing multiple sclerosis (RMS). Zinbryta (daclizumab HYP) is a humanized monoclonal antibody that is injected every four weeks, and being developed by…

MS research shows that adipose-derived mesenchymal stem cell therapy may potentially repair the damage and inflammation seen in the nervous system of patients with MS.  During an autoimmune reaction, the myelin sheath coating which is formed around the axons of neurons slowly deteriorates, thus causing physical and cognitive impairments.  By…

Opexa Therapeutics, Inc., announced that its president and chief executive officer, Neil K. Warma, recently gave a presentation on immunotherapy and its potential for treating autoimmune disorders, including multiple sclerosis, at the recent Cellular Horizons: The Third International Conference on the Progress of Regenerative Medicine and its Cultural Impact held at the Vatican. Neil…

A major new European research program to develop ways of monitoring three main central nervous system diseases —multiple sclerosis (MS), depressive disorder, and epilepsy — using wearable devices and smartphones was launched on April 26. The RADAR-CNS (Remote assessment of disease and relapse Central Nervous System) project, supported by the Innovative…

Dr. Fred Lublin, a neuroimmunologist with a specialty in experimental therapies, will open this year’s annual meeting of the Consortium of Multiple Sclerosis Centers on June 1 with an address questioning the continuing importance of relapses in multiple sclerosis (MS). But the question raised by the title of the…

MedDay recently disclosed full study results from the MS-SPI and MS-ON Phase 2b/3 trials of its therapeutic candidate MD1003 in patients with multiple sclerosis (MS). Specifically, the trials included people with “not active” progressive MS and those with either relapsing or progressive MS and visual loss, respectively. Data, presented at the recent American…

Researchers at the School of Medicine of the University of California (UC), Riverside, found that TNF-alpha, a factor known for its pro-inflammatory actions, also triggers processes that end inflammation by inducing a type of immune surveillance cell, called M-cells. By advancing our understanding of immune processes, the finding may lead to…

Multiple sclerosis patients using a cognitive remediation computer training program, part of a controlled trial by researchers from NYU Langone Medical Center, had greater improvements in cognitive function than those who used a placebo-training program, according to a presentation at the recent American Academy of Neurology annual meeting in Vancouver, Canada. Problems in attention, memory,…

New data presented by Biogen and AbbVie at the recent 68th annual meeting of the American Academy of Neurology (AAN) showed that Zinbryta (daclizumab high-yield process) improved cognitive outcome measures in patients with relapsing forms of multiple sclerosis (RMS). Additional results — from post-hoc analyses of clinical trials — also offer a better…

Mabthera (rituximab), a widely approved drug for treating lymphoma and/or rheumatoid arthritis, is highly effective in treating multiple sclerosis (MS), researchers reported in an observational study in Sweden, where Mabthera is increasingly being used outside of its approved indications to treat relapsing-remitting MS patients. The study, published in the journal…

Biogen reported new data describing the effectiveness of Tecfidera (dimethyl fumarate) in newly diagnosed relapsing-remitting multiple sclerosis (RRMS) patients in a recent presentation at the 68th annual meeting of the American Academy of Neurology (AAN). The conference, taking place in Vancouver, Canada, runs through April 21. Tecfidera is an…

A Phase 2 clinical trial testing the efficacy of a common antihistamine, clemastine fumarate, to treat optic nerve damage in people with multiple sclerosis (MS) found the drug able to slightly reverse damage to their visual system. The  study, conducted by researchers at the Multiple Sclerosis Center at the University of California San…

The Consortium of Multiple Sclerosis Centers (CMSC) 2016 Annual Meeting will open with the John F. Kurtzke Memorial Lecture, “Do Relapses Really Matter?”, by the renowned multiple sclerosis (MS) expert Dr. Fred D. Lublin of Mount Sinai Medical Center. The June 1 lecture offers a fresh view on recent evidence into the impact…

Sanofi Genzyme will present new data on its approved multiple sclerosis (MS) treatments — Lemtrada (alemtuzumab) and Aubagio (teriflunomide) — at the 68th annual meeting of the American Academy of Neurology (AAN), taking place in Vancouver, Canada, through April 21, as well as data on investigational therapies in its pipeline. In total, the meeting…

Innate Immunotherapeutics, Ltd., announced that it has completed patient enrollment in its ongoing Phase 2B, placebo-controlled clinical trial assessing the efficacy and safety of the drug MIS416 as a once-weekly treatment for secondary progressive multiple sclerosis (SPMS). MIS416 is a biologically derived immune modulator that targets myeloid cells, a subset of innate immune cells that can…

Teva Pharmaceutical Industries, Ltd., announced that new data on four of its products, including an approved and a potential treatment for multiple sclerosis, will be presented at the 68th Annual Meeting of the American Academy of Neurology (AAN), running through April 21 in Vancouver, Canada. The data, to be…

A range of new multiple sclerosis (MS) data from Biogen will be revealed at the 68th annual meeting of the American Academy of Neurology (AAN) in Vancouver, Canada, on April 15–21. Presentations will include studies on Tecfidera (dimethyl fumarate), one of the most frequently used oral MS treatments worldwide, as well as several other…

Genentech announced that it will present new data from three Phase 3 clinical trials of its experimental multiple sclerosis (MS) therapy Ocrevus (ocrelizumab) at the 68th annual meeting of the American Academy of Neurology (AAN) being held in Vancouver, Canada, from April 15–21, 2016. Additionally, results of a new endpoint for…

PathMaker Neurosystems, Inc., recently announced the launch of an Institutional Review Board (IRB)-approved clinical trial, in partnership with Northwell Health (formerly North Shore-LIJ Health System) and The Feinstein Institute for Medical Research, to evaluate the safety and efficacy of MyoRegulator for the treatment of spasticity, one of the most common symptoms in multiple sclerosis…

Mice with experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), were found to have milder symptoms if the target of natalizumab (Tysabri) — VLA4 — was absent on B-cells, preventing regulatory cells that might control immune processes from entering the brain. B-cells are increasingly thought to play…

The National Multiple Sclerosis Society announced that it has invested $25.3 million to support nearly 60 new research projects aiming to better understand and treat multiple sclerosis (MS), and seven clinical training awards as part of its strategic approach to eventually curing MS. This investment is part of the Society’s plan to commit a…

The National Multiple Sclerosis Society is funding a new survey to understand how people living with multiple sclerosis (MS) weigh risks against benefits when choosing MS therapies. The survey was developed by Dr. Robert Fox, a neurologist, working with colleagues at the Cleveland Clinic and the MS patient…

Researchers reported that patients with myelitis who later develop multiple sclerosis (MS) might be distinguished from others with myelitis by a number of characteristics, like the location and size of spinal cord lesions, a finding that might help clinicians diagnose MS and initiate treatment at an early stage. Myelitis, an…