Tofranil (imipramine) for Bladder Dysfunction in MS

When people with multiple sclerosis (MS) experience bladder dysfunction such as urinary frequency and incontinence, doctors mayĀ prescribe a medication such asĀ Tofranil (imipramine)Ā to treat or manage the problem.

TofranilĀ is a tricyclic antidepressant that is more commonly used to treatĀ depression, but people with MS may find it helpfulĀ to treat annoying bladder symptoms. Occasionally it may also be used for neurologic pain in MS patients.

For urinary incontinence, TofranilĀ is usually taken one hour before bedtime, starting with a 25 mg tablet that may be increased to a maximum ofĀ 150 mg (in 25 mg increments).

Common side effects may include a tingly feeling, weakness, lack of coordination, dry mouth, nausea, vomiting, constipation, diarrhea, vision changes, ringing in the ears, swelling in the breasts in men or women, and decreased sex drive, impotence, or difficulty having an orgasm.

TofranilĀ has a black box warning (information on a prescription drugā€™s label that’sĀ designed to call attention to serious or life-threatening risks) concerning an increased risk of suicidal thinking and behavior in children, teenagers, and young adults with major depressive and other psychiatric disorders, especially during the first months of therapy or following dosage changes.

Read the latest news here about bladder dysfunction and multiple sclerosis.

Note: Multiple Sclerosis News TodayĀ is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.