Multiple sclerosis (MS) patients are largely moving away from injectable drugs and towards oral treatments when they switch from first to second-line MS therapies. But that might change with the introduction of Ocrevus (ocrelizumab), which has become the drug of choice for many neurologists advising patients on drug switches.
In an overview of patient medical records, Spherix — in collaboration with their neurologists — assessed the treatment choices of more than 2,000 MS patients. The group consisted of 1,020 patients who were receiving their first MS therapy, and 1,002 patients who were switching treatments.
The data showed that doctors are increasingly prescribing oral drugs such as Sanofi-Genyzme‘s Aubagio (teriflunomide), Novartis‘ Gilenya (fingolimod) and Biogen‘s Tecfidera (dimethyl fumarate) for patients as a first-line treatment. In addition, neurologists at MS specialty centers and those who cannot offer patients infusion therapy are more likely to prescribe oral MS treatments as a first treatment option.
The analysis also showed that patients who start oral disease-modifying therapy usually have higher disability scores as measured by the Expanded Disability Status Scale, compared to those who start so-called platform injectables such as interferons and Teva’s Copaxone as first-line treatment.
Although data showed that Copaxone (glatiramer acetate) is still one of the most widely prescribed first-line drugs, doctors are increasingly prescribing the competitor injectable glatiramer acetate — Sandoz‘s Glatopa, with insurance coverage being a major contributing factor for this.
But MS patients are switching treatments faster than ever. Neurologists report about 30 percent of patients change treatments each year. Among the 1,002 switch patients analyzed, most were moving from their first to their second treatment. Most moved away from platform injectables during the shift.
In the switch report, Spherix noted that infusion treatments or monoclonal antibodies become more prominent with every treatment switch.
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