Since more relapses occurred in women who quit the treatment before this time, researchers from the Ludwig Maximilian University of Munich in Germany concluded that 30 weeks was the optimal time interval to stop the treatment in pregnant women.
The data was shown at a presentation at the 7th Joint ECTRIMS-ACTRIMS Meeting in Paris, France, a gathering of more than 9,000 researchers at one of the largest MS-focused meetings in the world.
The risk of a drop in blood cell counts in babies born to mothers on Biogen’s Tysabri is a known effect, but it rarely has been studied in relationship to relapses among mothers who quit the treatment during pregnancy.
The study, “Long-term exposure to natalizumab during pregnancy – a prospective case series from the German Multiple Sclerosis and Pregnancy Registry,” turned to the German Multiple Sclerosis and Pregnancy Registry to determine if there was an optimal time to stop treatment with the drug.
The team identified 40 women treated with Tysabri, enrolled in the registry.
Among 32 babies in which blood cell counts were available upon birth, 15 had abnormally low cell counts. One-third was in the group of mothers who stopped treatment before week 24, and 39 percent were in the group who quit Tysabri before week 30.
Babies had either anemia — a lack of red blood cells — or a lack of platelets. Only one newborn received treatment for the condition.
We are sorry that this post was not useful for you!
Let us improve this post!
Tell us how we can improve this post?