Author Archives: Margarida Maia

Skin Reactions ‘Frequent’ With Mavenclad, Real-world Study Finds

Skin reactions are common among relapsing-remitting multiple sclerosis (RRMS) patients being treated with oral Mavenclad (cladribine), affecting about one-third of the people evaluated in a real-world study in Germany. These findings suggest the need for careful clinical surveillance to rapidly diagnose and possibly treat skin problems stemming from Mavenclad’s use,…

US Study: Black Patients Have More Severe Disease Than Whites

Blacks with multiple sclerosis (MS) have more severe disease and greater disability at their first visit than white patients, even when differences in socioeconomic status are taken into account, a large U.S. study found. The data showed that Black patients with MS had lower scores on some measures of…

Impaired Social Cognition May Affect Well-being of RRMS Patients

Impaired social cognition — lacking the ability to understand and process others’ emotions — may affect how people with relapsing-remitting multiple sclerosis (RRMS) feel on a day-to-day basis, a small, three-year study has found. RRMS patients with such difficulties were “characterized at follow-up by a higher level of depression…

PicnicHealth, Komodo Pool Real-world Data for Research

PicnicHealth and Komodo Health have agreed to combine their databases of patient medical records to support research based on real-world evidence. Together, the companies hope to unlock new insights into complex diseases like multiple sclerosis (MS). “Komodo Health and PicnicHealth share a mission to utilize health data…

US Patent Issued for Software That Could Make MRI Scans Safer

Subtle Medical announced the granting of a U.S. patent for its radiology software that uses artificial intelligence to improve the quality of medical imaging, with the potential to reduce the amount of gadolinium, a contrast agent, needed to one-tenth of its usual dose. Gadolinium, a heavy metal, is included in…

Repertoire, Yale Working to Identify T-cells Driving MS

Repertoire Immune Medicines and Yale University have entered a research collaboration to identify what type of antigens are activating immune T-cells in patients with multiple sclerosis (MS). Antigens are molecular structures, such as a portion of a protein or a specific chain of sugars, that trigger an immune…

Helper T-cells Drive Transition from RRMS to SPMS, Study Suggests

A group of helper T-cell (Th cells), a type of immune cell, could be responsible for the transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive multiple sclerosis (SPMS), with important implications for diagnosing and treating SPMS, a new study found. The study, “Involvement of cytotoxic Eomes-expressing…

Vumerity Linked to Better Quality of Life Than Tecfidera in RRMS Trial

Vumerity (diroximel fumarate) is easier on the gastrointestinal tract than Tecfidera (dimethyl fumarate), and this translates into better quality of life for patients with relapsing-remitting multiple sclerosis (RRMS), a new analysis of EVOLVE-MS-2 trial data has found. The study, “Improved gastrointestinal profile with diroximel fumarate is…

Ocrevus May Delay by 7 Years PPMS Patients’ Need for Wheelchair

Ocrevus (ocrelizumab) treatment may delay the need for a wheelchair by seven years in patients with primary progressive multiple sclerosis (PPMS), a study reports. This delay, drawn from clinical trial data on treatment- versus placebo-group patients and supported by real-world findings, likely translates to long-term benefits for PPMS patients,…

Vitamin D Supplements at Preclinical Stage Prevented MS in Mice

Vitamin D, but not paricalcitol (a vitamin D analog), can be used as a preventive measure to control the severity of multiple sclerosis (MS), according to a new study of mice. The study, “Preclinical therapy with vitamin D3 in experimental encephalomyelitis: Efficacy and comparison with paricalcitol,” was…

Lipid Signaling Molecule Regulates Immune Responses in Mice

Lipid (fat) molecules can function as chemical couriers, taking messages from tissue to tissue, organ to organ as part of the body’s immune defense guidance system. But in certain diseases such as multiple sclerosis (MS), the courier service may go awry. One such lipid molecule, called sphingosine 1-phosphate (S1P),…

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