Potential new ways of capturing disease progression in multiple sclerosis (MS) patients — including those with chronic as opposed to active inflammation — are coming to the fore as analyses continue into the huge amounts of data collected during pivotal clinical trials that led to Ocrevus’ approval, a leading Genentech researcher said in an interview.
“At ECTRIMS, we’ve introduced a measure called PIRA — progression independent of relapse activity — and here we look at progression that’s independent of the relapses,” Hideki Garren, group medical director of ocrelizumab for Genentech, told Multiple Sclerosis News Today. “Progression [that] appears to be driven by chronic inflammation.”
It has “a very significant impact” on MS patients, Garren said, both in terms of mobility and life quality. Garren spoke at the four-day 7th Joint ECTRIMS-ACTRIMS Meeting in Paris that ended on Oct. 28.
PIRA emerged as a possible measure of increased disability in a post-hoc analysis of data on the 1,656 relapsing MS patients enrolled in the OPERA I and OPERA II (NCT01247324 and NCT01412333) Phase 3 trials, of which 827 were treated with Ocrevus (ocrelizumab) and 829 with Rebif (interferon beta-1a).
Data also showed “a significant reduction” — about 40 percent — in underlying progression in those treated with Ocrevus compared to those given interferon, Garren said.
Another potential biomarker coming from this continuing work is an “automated methodology” — an algorithm — applied to what is seen on conventional MRI scans. It shows what Genentech, a division of Roche, calls SELs, or slowly evolving lesions. SELs may be markers to detect disease activity that’s taking place outside of active lesions in a patient.
“We’re excited about this potential biomarker for chronic inflammation,” Garren said.
In the interview, he also talked about the importance of the FLOODLIGHT study, gathering both “active and passive” data on patients using sensors connected to a smartphone. Active data are collected in a “pinch test” or the like, while passive data is gathered while patients in the study go about their day.
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