January 8, 2024 News by Marisa Wexler, MS In MS, spinal cord atrophy, chronic inflammation predict progression In people with multiple sclerosis (MS), disability worsening independent of relapse activity ā commonly known as “silent progression” ā tends to be accompanied by greater atrophy, or shrinkage, in the spinal cord, as well as a higher number of lesions with chronic inflammation, known as paramagnetic rim lesions or…
October 2, 2023 News by Marisa Wexler, MS Most disability worsening on Ocrevus not tied to relapses: Study Among multiple sclerosis (MS) patients treated with Ocrevus (ocrelizumab), most of the disability worsening they experience is not associated with any relapse activity, according to an analysis of real-world data. “We present real-world data from our multiple sclerosis center underlining that in a typical population of relapsing MS…
October 31, 2022 News by Marta Figueiredo, PhD #ECTRIMS2022 ā Relapse-free Progression Evident in Pediatric MS Disability progression in the absence of relapses is less common in children and adolescents with multiple sclerosis (MS) than among people with adult-onset disease, according to data covering more than 5,000 patients with relapsing forms of MS. Nevertheless, this form of progression ā called progression independent of relapse activity,…
September 12, 2022 News by Lindsey Shapiro, PhD Progression Without Relapse Also Common in RRMS, Patients Say Nearly two-thirds of people with relapsing-remitting multiple sclerosis (RRMS) report disease progression independent of relapses, according to a survey involving more than 4,500 multiple sclerosisĀ (MS) patients in Germany. This finding supports evidence pointing to progression independent of relapse activity (PIRA) as an underestimated contributing factor in RRMS.
May 25, 2022 News by Marta Figueiredo, PhD ‘Silent Progression’ in Relapsing MS Linked to Significant Brain Atrophy People with relapsing multiple sclerosis who have disability progression, but no clinical relapses, show significantly faster brain shrinkage, or atrophy, than those with a stable disease, a study shows. There were no significant differences in the brain atrophy rate between patients with progression independent of relapse activity (PIRA) and…
March 11, 2022 News by Marisa Wexler, MS Worsening Disability in Absence of Relapses ‘Underestimated’ in MS A substantial amount of disability worsening happens independently of relapses in people with multiple sclerosis (MS), including those in earlier stages of relapsing-remitting disease, a study in a large patient database reported. While its findings “confirm relapses contribute to the accumulation of disability, primarily early in multiple sclerosis,” data…
October 18, 2021 News by Marisa Wexler, MS #ECTRIMS2021 ā Relapse-free Worsening More Likely in Late-onset MS Editorās note: TheĀ Multiple Sclerosis News Today team is providing in-depth coverage of the virtual 37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Oct. 13ā15. GoĀ hereĀ to see the latest stories from the conference. People…
October 31, 2017 News by BioNews Staff #MSParis2017 ā Ocrevus Trial Data May Lead to Key Biomarkers of Chronic Inflammation, Genentech Says Potential new ways of capturing disease progression in multiple sclerosis (MS) patients ā including those with chronic as opposed to active inflammation ā are coming to the fore as analyses continue into the huge amounts of data collected during pivotal clinical trials that led to Ocrevus’ approval, a leadingĀ GenentechĀ researcher…