Margarida Maia, PhD, science writer —

The level of proteins called kappa free light chains in the cerebrospinal fluid (CSF) — the liquid that surrounds the brain and spinal cord — may be used as a diagnostic marker to identify the presence of primary progressive multiple sclerosis (MS), according to a new study. Testing for…

Myrobalan Therapeutics has secured $24 million in series A financing to support the development of oral medications for multiple sclerosis (MS) and other diseases of the central nervous system (CNS), which comprises the brain and spinal cord. The company’s pipeline currently includes three candidate therapies…

Engaging in online sessions of compassion-focused therapy, which works toward getting people to become more compassionate about themselves, may help women with multiple sclerosis (MS) deal with suicidal thoughts, a small study suggests. Compassion-focused therapy also may help these women overcome pain catastrophizing, which is a tendency to view…

Six of eight patients with nonactive secondary progressive multiple sclerosis (SPMS) being treated with foralumab nasal spray — all part of an intermediate-size expanded access program (EAP) allowing the therapy’s use — have experienced reductions in their fatigue levels. That’s according to treatment developer Tiziana Life Sciences,…

Adults with multiple sclerosis (MS) or traumatic brain injury report more cognitive fatigue, or exhaustion resulting from mental work, than do healthy individuals — regardless of the nature of the tasks being performed — a study found. However, cognitive fatigue built up at a similar rate among study participants…

A six-month telehealth program designed to help participants change their dietary and lifestyle habits resulted in an increased level of physical activity and clinically relevant weight loss for most obese people with multiple sclerosis (MS) who took part, a clinical trial found. In fact, about 2 in 3 of…

Fewer men than women are diagnosed with multiple sclerosis (MS) in China — as elsewhere — but more male patients have faster MS disability progression and higher death rates, a study found. Over the next 25 years, the burden of MS is expected to persist in China, the researchers…

More than one-third of neurologists in the U.S. believe Bruton’s tyrosine kinase (BTK) inhibitors could be of pivotal significance as a future treatment of multiple sclerosis (MS), according to findings of a recent Spherix Global Insights’ survey. “Through Spherix’s quarterly RealTime Dynamix market tracker, neurologists…

Taking a ginger supplement eased constipation, nausea, bloating, and abdominal pain in people with relapsing-remitting multiple sclerosis (RRMS) who took part in a small clinical trial in Iran. The findings add to previous trial data that indicated the supplement was associated with less disability and improved quality of…

People with multiple sclerosis (MS) are more likely to experience depression, sexual dysfunction, constipation, inflammation of the bladder, and urinary tract infection in the five years leading up to their diagnosis than those without the disease, a study found. These findings parallel growing evidence that there’s a prodromal phase, in…

Treatment with Mavenclad (cladribine) over two years significantly improved physical and mental health aspects of quality of life in people with highly active relapsing multiple sclerosis (MS), according to a final analysis of data from the Phase 4 CLARIFY-MS study. Mavenclad is an oral medication approved for people with…

People with primary progressive multiple sclerosis (PPMS) at younger ages are more likely to have higher disease activity, suggesting they may respond better to disease-modifying therapies, according to a review of published studies. “Our findings confirm that younger patients tend to have more inflammatory activity, and so younger…

The Patent and Trademark Office intends to grant a U.S. patent covering all dosing regimens of vidofludimus calcium — being developed as IMU-838 — for the treatment of multiple sclerosis (MS). That includes the doses being used in developer Immunic Therapeutics’ ongoing clinical program, according to a…

COVID-19 doesn’t appear to increase the likelihood of a relapse, where new symptoms suddenly appear or existing ones worsen, for people with multiple sclerosis (MS), according to a meta-analysis of more than a dozen studies. The findings alleviate some of the concerns MS patients may have about developing COVID-19,…

Central neuropathic pain — the kind resulting from damage to the brain and spinal cord — appears to be more severe and widespread and to cause more emotional burden in people with multiple sclerosis (MS) than pain in muscles and joints, according to a recent study. Regardless of pain…

A high level of adherence to disease-modifying therapies (DMTs) is associated with a significant, 25% lower risk of moderate or severe relapses in previously untreated people with multiple sclerosis (MS) compared with those failing to adhere to therapy, according to a study of real-world data in Italy. High…

Immunic Therapeutics has been notified of the intent to grant a U.S. patent covering the use vidofludimus calcium (IMU-838) in treating relapsing forms of multiple sclerosis (MS) at a daily dose of about 10 to 45 mg. That range covers the two IMU-838 doses shown to be…

Combining a saffron supplement and an exercise program for three months was seen to significantly ease depression and improve quality of life for women with multiple sclerosis (MS), a study in Iran found. The combination of the two treatments worked better than either approach alone. “Although … the corrective…

Neural Sleeve, a bionic piece of clothing by Cionic designed to help with walking and strength, is among the 200 devices on Time magazine’s annual list of best inventions, under its accessibility category. The lightweight, leg-worn device, which combines continuous motion analysis with functional electrical stimulation,…

Low blood levels of vitamin D are tied to poorer cognitive skills and more severe disability in people with multiple sclerosis, researchers in Italy report. “Our study showed that [vitamin D] levels are associated with cognitive function in MS, as already well demonstrated in the general population and in…

Socioeconomic factors, specifically income and education levels, and marital status, were identified as risk factors for multiple sclerosis (MS) severity in a new study in Sweden. In fact, the study found that earning a higher income and having more years of education before being diagnosed with MS are associated with…

People with multiple sclerosis (MS) who develop progressive multifocal leukoencephalopathy (PML) as a side effect of Tysabri (natalizumab) often see their neurological symptoms worsen severely during the infection and their disability gradually accumulate over time. That’s according to a study in Austria, which also showed that most disability progression…

Anxiety, depression, and other mental health issues are nearly twice as common in people with multiple sclerosis (MS) in the five years preceding disease onset than they are in the general public, a study reports. These findings add to growing evidence that people with MS often go through a…

People with multiple sclerosis (MS) who experience a greater number of more severe flare-ups, also known as relapses, are more likely to take their medications regularly, but less likely to keep taking them over time, a review study has found. Other factors associated with better treatment adherence and persistence…

The rate of brain atrophy, or volume loss, may help in determining whether disease-modifying therapies (DMTs) are slowing disability progression in people with relapsing-remitting multiple sclerosis (RRMS), a review of data from 12 published studies found. The analysis, “Brain Atrophy as an Outcome of Disease-Modifying Therapy for…

Certain COVID-19 vaccines do not appear to worsen the symptoms of multiple sclerosis (MS), and may provide protection for at least six months after a booster dose, according to a study in Spain. The study specifically examined mRNA vaccines, or those that use a piece of RNA to teach…

People with multiple sclerosis (MS) in the U.S. who have access to a Shields Health Solutions care model pay an average $10 out of pocket each month for their MS treatments, according to the company — which noted that this amount is considerably less than the national average…

Four researchers working in multiple sclerosis (MS) were awarded incubator grants in MS Australia’s latest funding round, which they’ll use to kickstart projects designed to better understand the progressive neurodegenerative disease. Worth a total of AU$92,565, or roughly $60,000, this round of incubator grants provides seed funding…

Children and adolescents with multiple sclerosis (MS) who receive high-efficacy disease-modifying therapies (DMTs) early on are significantly less likely to experience a relapse than those given a less efficacious drug, a real-world study found. While most patients on moderate-efficacy therapies eventually switched to a more effective one, a…

Atara Biotherapeutics now is planning to announce in November the one-year data from its EMBOLD Phase 1/2 study, which is testing the company’s experimental treatment ATA188 for progressive forms of multiple sclerosis (MS). The results, originally expected in October, will cover the trial’s primary endpoint of…