MS News that Caught My Eye Last Week: High Cost of MS Meds; MS Progression, Relapse, and DMT Timing; Remyelinating Therapy Trial; Myelin Regeneration Mouse Study
Almost Half of MS Patients Change or Stop DMT Due to High Financial Burden, Survey Shows
I frequently see reports of this on multiple sclerosis patient websites. People with MS say they’ve been forced to change or even stop their treatment because it costs too much. Some people have had to choose between paying for their medication and buying food. This should not be happening. Have you ever had to reduce your MS treatment because of its cost?
The high cost of disease-modifying therapies (DMTs) for multiple sclerosis (MS), and the challenging process of insurance approval, lead to treatment gaps or alterations, increased symptoms, and sacrifices in lifestyle, a survey from the National Multiple Sclerosis Society (NMSS) shows.
“People with MS are paying the price, not only financially, but also physically and emotionally,” Bari Talente, NMSS’s executive vice president of advocacy, said in a press release.
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MS Progression Affected by Degree of Relapse Recovery and Timing of DMT Use, Study Says
More and more neurologists are recommending that a disease-modifying therapy be started soon after an MS diagnosis. Yet, many neuros and their patients continue to wait to begin treatment until after significant disease progression has occurred. Are people scared of the meds? Or perhaps it’s a problem of affordability. Maybe this study will tip the scale toward earlier treatment. Based on my experience of living with MS for nearly 40 years, I think that would be a good thing.
Recovering well after a first relapse and starting a disease-modifying therapy (DMT) immediately afterward considerably increases the likelihood of slowing progression in multiple sclerosis (MS), a study suggests.
Its findings support relapse recovery as a critical factor for DMT initiation, and one that should be assessed routinely in MS clinical trials, researchers said.
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First MS Patient Dosed in Phase 2 Trial of Potential Remyelinating Therapy CNM-Au8, Clene Announces
This possible therapy is designed to facilitate specific chemical reactions within cells and promote the activation of oligodendrocytes, the cells responsible for producing myelin. Hopefully, it will help to remyelinate the nerves damaged by MS. The CEO of Clene Nanomedicine, which produces CNM-Au8, says he believes this therapy has a strong potential for myelin repair in people with MS. Let’s hope he’s right.
The first participant has been dosed in the Phase 2 REPAIR-MS clinical trial examining the effects of CNM-Au8, Clene Nanomedicine‘s investigational remyelinating therapy, on brain metabolism in people with multiple sclerosis (MS), the company announced.
In MS, the immune system attacks myelin, the protective sheath that surrounds neurons, helping them send signals more effectively.
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New Mechanism Boosting Myelin Regeneration May Ease MS Symptoms, Mouse Study Shows
I don’t usually mention mouse studies because treating a mouse is a lot different than treating a person. But since we’ve just discussed remyelination, I thought it would be interesting to look at another potential process to accomplish that.
Blocking a protein called PAR1 may enhance the regeneration of myelin, the protective fatty layer that covers nerve fibers and is damaged in multiple sclerosis (MS), a mouse study shows.
Therapeutic targeting of PAR1 may promote remyelination and delay MS progression, according to the study, “Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain,” published in the Journal of Neuroscience.
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About the Author
Deborah Wagner
I haven’t taken MS drugs for 30 of my 40 years of ms. In the beginning I was a poster child for the worst case in my area. Thankfully, I did bounce back with ACTH. Have I slowly deteriorated? You betcha but cost of drugs are too high. I’m going to revisit again but don’t know what’s out there for me. I have finally been able to see a local neurologist which helps quite a bit. Traveling two hours one way to see a specialist hasn’t helped. We’ll see.
Alan
High drug process are GOOD FOR MS PATIENTS! That's why there is so much research and development of new drugs. If the drugs earned half of what they earned now, there world be less money available for research and a drug dropping from $80,000 to $40,000 isn't going to be any cheaper to the patient.
If you are not on government benefits, the pharmaceutical companies will cover your copay. If you are on government benefits, then your process won't change of the price lowers.
High MS drug prices are good.
Dan
Alan I am not sure how you came to this conclusion. I see that even if the medication it is super expensive and probably the cost of production are not even 5%, no one is releasing one that cures MS. If you are looking only how much donations are world wide and how much money they get from the governments for research programs, it should be enough. So that it is not an excuse for the price. Just look at the case of Zolgensma.